Southern Railway, in its present form, came into existence on 14th April 1951 through the merger of the three state railways namely Madras and Southern Mahratta Railway, the South Indian Railway, and the Mysore state railway.

Franco-Indian Pharmaceuticals Pvt. Ltd., a name that stands for quality and innovation, is one of the major players in the Pharmaceutical Industry in India.

Dr. Kanase Health Care Pvt. Ltd. is one of emerging health Management Company with well demonstrated research, and marketing capabilities.

Post: Area Business Manager, Medical Representatives

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu.

About Authors:
Patel Punita s*, Patel Brilina M, Arora Bhoomi
Institute of clinical research India
ahmedabad, Gujarat
*punitapatel_icri@ymail.com

Abstract:
Bullous Pemphigoid (BP) is an autoimmune subepidermal blistering disease appearing predominantly in the elderly. Bullous Pemphigoidcharacterized by an autoimmune response to 2 hemidesmosomal proteins within the dermal–epidermal junction, These proteins, called BP antigen 1 (BPAG1 or AgBP230), and BPAG2 (or AgBP180 or collagen XVII) have respective molecular masses of 230 and 180. While BP180 is a transmembrane glycoprotein with an extracellular domain BP230 localizes intracellularly and associates with the hemidesmosomal plaque. The disease is characterized clinically by tight bullae, with clear content, often large, developing primarily on the edge of erythematous plaques. Intense itching is common. The disease is primarily treated with systemic corticosteroids. Now,The increased knowledge of the development of noveltherapeutic strategies for Bullous Pemphigoids.

The National Institute of Virology is an apex National Lab. of the Indian Council of Medical Research for diagnosis of diseases of suspected viral etiology all across the country and carrying out high quality research on viral infections viz; arbovirus and Crimean congo, hemorrhagic fever, KFD, Chandipura, Nipah, dengue, Chikungunya, JE, West Nile, H5N1//swine flu H1N1, Hepatitis, Harpes simplex, measles, enteroviruses, Polio, and other emerging and re-emerging viral infections.

About Authors:
H.S.Sawwalakhe*, J.M.Maidankar, M.A.Channawar, Dr.A.V. Chandewar
P. W. College of Pharmacy, Yavatmal,
Amravati university
*hemant_11sep@rediffmail.com

ABSTRACT:
The demand for mouth dissolving tablets has been growing during the last decade especially for elderly and children who have swallowing difficulties. Chlorpheniramine maleate is a non-steroidal anti-inflammatory drug (NSAID) histamine H1 antagonist with antihistamine drug it is commonly used  in allergic reactions, hay fever, rhinitis, urticaria, and asthma. The main criteria for mouth dissolving tablets are to disintegrate or dissolve rapidly in oral cavity with saliva in 15sec to 60sec with need of water. The disintegrants used should fulfill the criteria by disintegrating the tablets in specified time limit.in the present investigation variety of super disintegrants Crospovidone, sodium starch glycolate,kyron t-314 , were selected and tablets were prepared by direct compression method in different concentration like 3%,6% and 8%. The prepared tablets were evaluated for weight variation, hardness, friability, in vitro disintegration time, wetting time, in vitro dissolution study, etc.formulation f-9 shows the lowest disintegration time (29sec) and wetting time (37sec). In vitro dissolutionstudies revealed that formulation F-9 containning 9% t-314  showed 98% drug release at the end of 10 min.

About Author:
Balbir Singh Negi
GM Regulatory Affairs
SHAH TC Overseas Private Limited, Delhi, INDIA
22 years of industrial Exp,
M.Sc, MBA, Doctor of Science.

Abstract:
The usage of solvents in active pharmaceutical ingredients (API) and coating plants are very common in pharmaceutical industry. The organic solvents are mostly used in washing of product, cleaning of equipments and the reaction media for separation and purification. The cost reduction of the API products can be reduced by the distillation of mother liquor after establishing of yield in R &D, pilot plant and then in the commercial plant, the next process step is validation, done with fresh solvent of three consecutive batches and then done with three consecutive batches of recovered solvents from mother liquor. The product cost is mainly reduced by the distillation of product mother liquor or to do more research to reduce the quantity of solvent or manufacturing process without solvent.

AKUMS DRUGS & PHARMACEUTICALS LTD is one of the most innovative, productive and research based pioneer organization of India having its registered office at Delhi and various plants in Haridwar, Uttrakhand giving employment to more than 2000 people. Akums is engaged in the manufacturing of tablets, capsules, injections, syrups on loan licensing and third party manufacturing basis.

Dr. Reddy's Laboratories (NYSE: RDY) is an emerging global pharmaceutical company with proven research capabilities. The company is vertically integrated with a presence across the pharmaceutical value chain. It produces finished dosage forms, active pharmaceutical ingredients and biotechnology products and markets them globally, with focus on India, US, Europe and Russia.

Biocon is a research-driven, global healthcare company with a strong matrix of capabilities along the biopharmaceutical value chain. Focusing on unmet medical needs in cancer, diabetes and inflammatory diseases, it offers novel therapies on a platform of affordable innovation. Biocon together with group companies employs more than 2500 employees with approxmimately Rs 1,000 crore turnover and is expected to grow further during the current financial year.

One of Asia’s largest Co-operatives, manufacturing, distributing and Marketing a wide range of products: Vanaspati, Fertilizer, Insecticides, Canned food products etc.
Applications are invited from eligible candidates for the recruitment of below mentioned posts accompanied by two passport size photographs of the candidate, copies of the certificates/ testimonials self attested and fee as per proforma appended below. The other details are given as under:-

About Authors:
Rawat Pinki^1*, Rawat Preeti², Kumar Piyush³ Kanoujia Jovita³, Singh Sangeeta ¹
1. Institute of Pharmaceutical Science and Research, Unnao, U.P., India.
2.  L.T.R. College Of Technology, Meerut, U.P., India.
3. Curadev Pharmaceuticals Ltd., Kanpur, U.P., India.
*pnkrawat@gmail.com

Abstract:
Selective estrogen receptor modulators, called SERMs for short, blocks the naturally circulating estrogen in breast tissues and other estrogen-sensitive tissues in the body. Each estrogen receptor has a slightly different structure, depending on the kind of cell it is in. If a SERM binds to a estrogen receptor, there is no site available for estrogen to bind and it can't attach to the cell. SERMs are called "selective" because they bind to particular estrogen receptors. This selective binding action is sometimes called estrogen inhibition, or estrogen suppression.

Applications are invited upto 28th July 2012 for one post of Scientist ‘C’ (Organic Chemistry / Natural Product Chemistry) in the Pay Band PB-3 Rs.15600-39100 + Grade Pay Rs. 6600/- at the ICMR's Regional Medical Research Centre, Belgaum.

Post: Scientist C

Indian Institute of Science Education and Research Bhopal was created in 2008 by the Ministry of Human Resource Development, Government of India. Its mission is to provide quality science education to UG and PG students.

ABOUT AUTHORS:
¹ Shashi Kant^*,Satinder Kumar, Rajender Kumar,
Research scholar department of pharmacy.
² Dr. Bharat Prashar
HOD & Associate professor  Department of Pharmaceutical Sciences, Manav Bharti University, Solan (H.P)
* shashi_ranaute@yahoo.in

ABSTRACT:-
In this review article, we discussed about Bioavailability and bioequilance study, bioavailability means rate and extent to which active ingredients absorbed from a drug product and become available at site of action. This article provides the information about important aspect involved in bioequivalence and regulatory requirement for bioequivalence study. The rate or rapidity at which drug is absorbed is important consideration in treatment of acute conditions such as asthma attack in pain. Extent of absorption is of special significance in treatment of chronic conditions like hypertension, epilepsy. In this review we discussed all the factors affecting bioavailability from its dosage form, objective/purpose of bioavailability study, design and evaluation of bioequilance study, methods of assessing of bioavailability and bioequilance etc.

Applications must be submitted online through the official website of the Commission after 'ONE TIME REGISTRATION' .Candidates who have already registered can apply through their profile.

Department : Kerala Drugs Control

Translational Health Science and Technology Institute (THSTI) an initiative of Department of Biotechnology, Government of India and International AIDS Vaccine Initiative (IAVI), USA are seeking Principal Investigators for their new joint collaborative program to accelerate and advance HIV vaccine research and development.