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About Authors:
*R. Natarajan., Abirami. M, , Pavan kumar J, G. Murugananthan
Department of Pharmaceutics & research
Swamy Vivekanandha College of pharmacy
Tamil Nadu,  India
*svcpnatarajan@gmail.com

ABSTRACT
The work was carried out to formulate and evaluate the matrix transdermal patches of Lamivudine for the controlled delivery of drug in the body. The transdermal patches were prepared by the solvent casting method using Span-80 as a permeation enhancer and were prepared in different drug: polymer (Lamivudine: HPMC and Lamivudine: EC) ratios of 1:2.5, 1:5, without permeation enhancers and with permeation enhancers. The prepared transdermal patch were found to be good physicochemical properties, shows no skin irritation on the rat skin and  subjected to in vitro drug permeation study by using rat skin in phosphate buffer pH 7.4 for 24 hours. The comparative statistical analytical data (ANOVA) showed ‘p’ value < 0.0001 which suggest that the prepared formulation are extremely significant for transdermal delivery. The formulation (FPE2) ratio 1:5 of (Lamivudine: HPMC) patch with permeation enhancer showed best result among all the formulation. This formulation (FPE2) was subjected to in-vivo studies by using rat. The in-vivo studies of the patches were administrated transdermally to rat skin and while a standard solution of 10μg/ml was used as a control, and collected the plasma drug sample at different time interval and analyzed by HPLC. The in-vitro in-vivo correlation studies shows the regression value (R) 0.863 and correlated and to be linear.

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About Authors:
Utkranti D. Aher, *Tushar T. Shelke, Ekta P. Patel
JSPM’S Charak College of Pharmacy and Research,
Wagholi,  Pune
*tts.ccopr@gmail.com

ABSTRACT
Now a day’s medication systems that need frequent dosing are always with problems. So there is thrust in the area of pharmaceutical research to develop novel formulations, which will enhance the therapeutic efficacy of the existing drug. The goal of this study is to provide detailed and different techniques of pelletization such as powder layering, suspension and solution layering, globulation, freeze, extrusion - spheronization, cryopelletization etc. It has some merits, demerits and its characterization as a tool in the multipariculate drug delivery system.etc. It also gives brief idea about the evaluation of pellets and application of pelletization technique. Evaluation of quality of the pellets is discussed with reference to the size distribution, shape, surface morphology, specific surface area, friability and  tensile strength.

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