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ROLE OF ERLOTINIB IN NON-SMALL CELL LUNG CANCER AS WELL AS PANCREATIC CANCER: A REVIEW

About Authors:
Satyanand Tyagi*
*President, Tyagi Pharmacy Association & Scientific Writer,
Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 49 Publications (41 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 49 publications, 11 are International Publications).
*sntyagi9@yahoo.com
, +91-9871111375 / 9582025220

ABSTRACT:
Erlotinib is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the United States by Genentech and OSI Pharmaceuticals and elsewhere by Roche. In lung cancer, it extends life by an average of 3.3 months at a cost of CDN $ 95,000. The hydrochloride salt of a quinazoline derivative of the drug shows antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. Erlotinib hydrochloride is approved to be used alone or with other drugs to treat:
* Non-small cell lung cancer that is locally advanced or has metastasized (spread to other parts of the body). It is used in patients who have already been treated with other chemotherapy.
* Pancreatic cancer. It is used with gemcitabine hydrochloride in patients whose disease cannot be removed by surgery or has metastasized.

Erlotinib hydrochloride is also being studied in the treatment of other types of cancer. The aim of present article is to provide in depth knowledge about the drug Erlotinib as well as its role in treatment of non-small cell lung cancer as well as pancreatic cancer.The review has also focused about chemistry, pharmacology as well as clinical trial studies of the Erlotinib.

Opening for Chemical Engineer , Electrician in Mysore based Pharma MNC - freshers can apply

Mysore based MNC

Post: Chemical Engineer , Electrician

Job as Pharmacist (5 posts) and Pharma aids (8 posts) in Medbliss - freshers may apply

Medbliss, we are newly came into market and we are planning chain of retail pharmacies in HYD city

Post: Pharmacist (5 posts) and Pharma aids (8 posts)

Walk in for Production, QA, QC in Nirlife Healthcare | not for fresher

We are Rs. 6000 Crore diversified multi-product group engaged in manufacturing and marketing of Detergents, Soaps, vacuum Salt, Heavy Chemicals. Caustic Soda, Soda ash, Petrochemicals, Pharmaceuticals Formulation, Medical Disposable Devices Packaging & Printing Materials, and Fertilizers etc.

For our Pharmaceutical Division we invite individuals for following positions.

Opportunity for Medical Representative, Senior Executive - International Marketing in Dr. Kanase Healthcare

Kanase group of company is one of the largest privately held Indian company ingage in ITES, Healthcare, Food & Agro Industries.

Pharmacological Screening of Ethanolic Extract of Plant Solanum XanthocarpumOn Nephrolithiasis Rats

About Authors:
Amar Patil*, Shraddha Kanase
M.Pharm (Pharmacology)    
Department Of Pharmacology, Tatyasaheb Kore College Of Pharmacy,
Warananagar. Dist;Kolhapur, India .
*appatil.tkcp@gmail.com

Abstract:
Solanum Xanthocarpumhas been known traditionally in Indian system of medicine for the treatment of various metabolic disease and disorders. Since, the present study was carried out to know its applicability in urolithiasis condition. In the present study, extracts of Solanum Xanthocarpumwas prepared with Ethanol and used for evaluation of antiurolithiatic activity. In this study we systematically evaluated its property by using Ethylene Glycol induced Albinorats. This study also involves state of the art animal model to elucidate its probable mechanism of industrial guidelines of FDA, USA for pre-clinical evaluation of anti-Nephrolithiasis drugs.

Multiple vacancies in Sales & Marketing in Shine Pharmaceuticals

Shine Pharmaceuticals Ltd is a WHO-GMP and ISO Certified Pharmaceutical Formulations company having significant presence throughout India and International markets. Shine is engaged in the field of manufacturing and marketing of oral and injectable formulations in Neuropsychiatry, Cardiology. Anti-diabetics and Gastro segments. For expanding our business into new territories and strengthen our team, we require professionals for following positions.

Application are invited for the post of JRF in INDIAN INSTITUTE OF ADVANCED RESEARCH(IIAR) | Walk in

Applications are invited for the JRF position supported by DBT sponsored project on Medical Mycology in Immunology group with Dr. Reena Rajput.

Walk-in Interview on 22nd October, 2012 at 11:00 am

Indian Institute of Chemical Biology - IICB invites Scientist / Senior Scientist- 4 Posts

State Power Holding Company invites application for the post of Shift Chemist (Trainee)

Chhattisgarh State Power Holding Co. Ltd. invites application for the post of Shift Chemist (Trainee) in C.S. Power Generation Co. Ltd.

Post: Shift Chemist (Trainee)- 15

A RECENT APPROACH TOWARDS TRANSDERMAL DRUG DELIVERY BY VARIOUS TECHNIQUES

About Authors:
K.S.Khatri
S.K.Patel education and research, Kherva,
Mehasana-384001
kkhatri_pharm@yahoo.com

Abstract:
Interest in transdermal drug delivery systems has increased on several fronts over the past several years because of the inherent advantages over the oral delivery such as the avoidance of gastrointestinal absorption, enzymatic and pH associated deactivation. Stratum corneum forms highly lipophilic membrane and provides the greatest resistance to penetration of drugs. A number of chemical and physical permeation enhancement techniques have been investigated. Chemical enhancers represent the most widely studied approach to transdermal drug permeation enhancement but are associated with toxicity, therefore limiting their clinical application. In recent years the emergence of number of physical techniques has expanded the range of drugs that can be delivered transdermally. Promising new technologies involved in enhancing transdermal permeation are Abrasion, Electroporation, Sonophoresis/Phonophoresis, Pressure waves, Iontophoresis, Laser Radiation,Magnetophoresis, Microneedles, Needleless injection and many more. In the present reviewed tried to discuss alternate techniques of enhancing the transdermal transport.

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Find Jobs for M.Pharm, M.Sc, B.Pharm, B.Sc, MBBS, MD & More for month Jul 2012

Career as Drug Safety Associate @ Icon Clinical Research
science degree, pharmacy or nursing background you will have a minimum of 8 months experience in a drug safety environment.

Opportunity for M.Pharm, M.Sc, B.Pharm to work in areas of Pharmacognosy/Pharmacology and Tissue culture & Transformation @ CSIR-NBRI

NBRI is a premier plant based multidisciplinary, state-of-art national R&D Centre of CSIR undertaking research from classical taxonomy to cutting edge areas of modern biology-including both applied and basic research in the fields of biochemistry, bioinformatics, biotechnology, conservation biology, cytogenetics, environmental sciences, ethnopharmacology, floriculture, microbiology, molecular biology and genetic engineering, pharmacognosy

Opening for post of Pharmacist in DIRECTOR MEDICAL EDUCATION & RESEARCH - 4 posts

The following posts on contract basis for six months extendable as per Haryana Govt. Rules or till the regular candidate joins,are proposed to be filled on DC rates (Mewat) for Shaheed Hasan Khan Mewati, Govt. Medical College, Nalhar (Mewat).

Post: Pharmacist - 4 posts

Career in NIRRH as Junior Research Fellow (JRF) - 3 posts | walk in interview

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai. Since its inception in 1970, it has been making vigorous efforts to improve the reproductive health of people through research, education and health care services.

Work as Scientists, SRF, Research Associate in Central Pollution Control Board | Multiple vacancies

The Central Pollution Control Board (CPCB), statutory organisation, was constituted in September, 1974 under the Water (Prevention and Control of Pollution) Act, 1974. Further, CPCB was entrusted with the powers and functions under the Air (Prevention and Control of Pollution) Act, 1981.

Applications of Biosensors technology : Future trends development and new intervation in biotechnology

About Author:
KIRANKUMAR K. VAGHASIYA
M.Sc. Biotechnology
Bhagwan Mahavir College Of  Biotechnology, Surat
* vaghasiyakiran51@yahoo.co.in

Abstract:
Biosensors can be excellent analytical tools for monitoring programs working to implement legislation.Biosensor are analytical devices which are capable of providing either qualitative or quantitative results. Biosensor technology to be in a very early stage of development. There are many market opportunities. In this article, biosensors for environmental analysis and monitoring are extensively reviewed. Examples of biosensors for the most important families of environmental   pollutants, including some commercial devices, are presented. Finally, future trends in biosensor development are discussed. In this context, bioelectronics, nanotechnology, environmental pollution, and especially biotechnology seem to be growing areas that will have marked influence on the development of new biosensing strategies in the next future.At present There are various types of biosensor available for the number of industrial and diagnostic Applications.

HIV / AIDS EVOLUTION AND CONSIDERATIONS

About Authors:
Nishant kumar singh
Research Fellow,
ICRI (Ahm) and Cranfield University

* nishantsingh.shree@gmail.com

ABSTRACT:
Over 3 decades HIV/AIDS have been a major globally accepted challenge, from endemic to a catastrophic pandemic & explodes globally. Estimates says 33.3 million HIV +ve and 2.6 million newly HIV infected people are in 2009. Since the beginning of epidemic, nearly 30 million people have died from AIDS related cause[1].  From chimpanzees to human[2] and then human to human (migration[3], MSM, HS, IDU, MTC etc) and ultimately it transformed into pandemic. After 30 years we have advanced our treatment & Medicare knowledge of HIV and AIDS. Our scientist has developed several successful targets and drugs based on them, a highly effective therapy HAART currently in use (managing viral load & cell count for better patient survival rate) showing good results. Still HIV/AIDS is incurable, WHY? It shows the need of critical thinking from the very 1st initial step i.e. TARGET. HIV itself is the target; biotech and Pharmaceutical Company must consider nanotechnology & homologous approach for CCR5. Though it seems that we have control over it but if this goes out same way, than one day just due to the HIV typical characteristic of mutation and recombination the worst Catastrophic sub Saharan-Africa epidemic will become Pandemic.[i]

Multiple vacancies in Bengal Chemical & Pharmaceutical | Require General Manager/Dy. General Manager (Production), Chief Manager/ Manager/ Dy. Manager (Purchase / Store), Works Manager/Project Manager, Sr. Officer/ Dy. Manager, AREA SALES MANAGER

Bengal Chemical & Pharmaceutical Works Ltd.(BCPW)  is precursor of the present Company, Bengal Chemicals & Pharmaceuticals Ltd (BCPL).  Acharya P C Ray  took a rented house at 91 Upper Circular Road, Calcutta and started business with a meager capital of Rs 700.00. Since inception of the Company he was very much quality conscious and produced various products of British Pharmacopoeia standard.

Work as Project Assistant in The National Institute of Oceanography (NIO) | Walk in

The National Institute of Oceanography (NIO) with its headquarters at Dona Paula, Goa, and regional centers at Kochi, Mumbai and Visakhapatnam, is one of the 38 constituent laboratories of the Council of Scientific & Industrial Research (CSIR), New Delhi. NIO was established on 1 January 1966 following the International Indian Ocean Expedition (IIOE) in early 1960s.

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