JUN 2014 ARTICLE LIST >>
PharmaTutor (June- 2014)
ISSN: 2347 - 7881
Received On: 29/03/2014; Accepted On: 08/04/2014; Published On: 01/06/2014
AUTHORS: Nandu Kayande1*, Pankaj Kushwah2
1HOD Department of Pharmacology
2Department of Pharmacognosy
Nimar Institute of Pharmacy, Dhamnod,
Dhar, Madhya Pradesh, India
nandu_kayande@rediffmail.com
ABSTRACT:
The purpose of the present study was to evaluate the diuretic activity of glycyrrhiza glabra linn (Mulethi) in experimental animals by following the standard procedure. Randomly selected animals were divided into three groups of six animals each. The root of glycyrrhiza glabra linn was administered orally in the form of Kwatha at a dose of 6.2 ml/kg and 12.3 ml/kg. Parameters like volume of urine, pH of urine and urinary electrolyte concentrations like sodium, potassium and chloride were studied. glycyrrhiza glabra linn Kwatha increased the urine output in a dose-dependent manner. However, it did not affect the urinary electrolyte concentrations. From the present study, it can be concluded that the root of glycyrrhiza glabra linn has diuretic property.
How to cite this article: N Kayande, P Kushwah; Evaluation of Diuretic Activity of Glycyrrhiza Glabra Linn in Experimental Animals; PharmaTutor; 2014; 2(6); 167-170
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REFERENCES:
1. Pizzorno JE, Murray MT. Textbook of Natural Medicine, 2nd Edition. Harcourt Publishers Limited 1999, 768.
2. Novaretti R, Lemordant D. Plants in the traditional medicine of the Ubaye Valley. J Ethnopharmacol. 1990 Aug; 30(1):1-34.
3. Dafni A, Yaniv Z, Palevitch D. Ethnobotanical survey of medicinal plants in northern Israel. Ethnopharmacol. 1984 May; 10(3):295-310.
4. Fujita T, Sezik E, Tabata M, Yesilada E, Honda G, Takeda Y, Taanka T, Takaishi Y. Traditional medicine in Trukey VII. Folk medicine in Middle and West Black Sea regions. Econ. Bot. 1995; 49(4):406-22.
5. Alternative Medicine Review. 2005; 10(3): p.230.
6. Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza Sp. and its bioactive compounds. Phytotherapy Research. 2008; 22(6):709-24.
7. Bafna PA, Balaraman R. Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation, Phytomedicine 2005 Apr; 12(4):264-70.
8. Dehpour AR, Zolfaghari ME, Samadian T, Kobarfard F, Faizi M, Assari M. Antiulceractivities of liquorice and its derivatives in experimental gastric lesion induced by ibuprofen in rats. Int. J Pharm. 1995, 119:133-38.
9. Sharangadhara samhita, by Pandit Sharangadharacharya, Adhamalla's Dipika and Kasiramas Gudhartha Dipika, Chaukhambha orientalia, Varanasi, fourth edition, 2000, 145.
10. Saurabh Srivastav, Pradeep Singh, Diuretic activity of whole plant extract of Achyranthes aspera Linn, European Journal of Experimental Biology, 2011, 1 (2):97-102.
11. Bishop, M. L., etal. (2000). Clinical Chemistry: Principles, Procedures, Correlations (4thed.). Philadelphia, PA: Lippincott Williams & Wilkins.
12. Preeti N. Pandya, Hetal B. Aghera, B. K. Ashok, and Rabinarayan Acharya, diuretic activity of Linaria ramosissima (Wall.) leaves in swiss albino mice. Ayu. 2012 Oct-Dec; 33(4): 576–578.