Pharmacology Articles

About Authors:
PIYUSH PARASAR
SPS I.T.E.R BHUBANESWAR,
INDIA

INTRODUCTION- 
CANCER A DARKER SIDE OFLIFE LITERALLY MEANS A HOPE TO LIVE FURTHER GET DIMINISHED IN THE CASE OF CANCER. MAN HAS BEEN EXPOSED TO THE CHANGING SURROUNDING EVER SINCE HE CAME INTO EXISTENCE.IN THE PROCESS HE IS VULNERABLE TO THE NUMBER OF FATAL DISEASE AMONG WHICH CANCER IS A DREADED MALADY NEXT TO CARDIOVASCULAR  DISEASE. IT IS KNOWN TO ALL OF US THAT DEATH IS INEVITABLE BECAUSE IT IS A VICIOUS CYCLE OF THE NATURE. BUT THIS TYPE OF ESOTERIC DISEASE MAKES OUR LIVES FROM SIMPLE TO COMPLEX. SOME PEOPLE BELIEVE IN THE CONCEPT OF AS YOU SOW SOW YOU SHALL REAP ESPECIALLY IN INDIA. THESE ARE ALL SPECULATIONS OF OUR WAY OF THINKING AND THOUGHTS. IN MAJORITY OF CASES WE HAVE SEEN THAT DUE TO OUR MODERN LIFESTYLE WE GET SUFFERED FROM THESE TYPE OF DISEASE.

About Authors:
Sudhir Ghawade,
Vidyabharati college of pharmacy,
Amravati

Abstract:
In recent times, focus on plant research has increased all over the world.Caesalpinia crista (Caesalpiniaceae)plant is well known for its medicinal and therapeutic values in Indian Ayurveda.The Indian traditional scriptures as well as the Ayurvedic texts have various references to the use of this plant. The bitter principles Bonducin and Natin are the primary constituent of Caesalpinia crista apart from linolic acid, fatty acid, setasitosterol and different diterpenes  which mainly believed to be responsible for its wide therapeutic action. The plant has been recommended for the treatment of various diseases and disorders such as Antispasmodic, Malarial fever, leucorrhea, abdominal pain , rheumatoid, arthritis, diabetes,cystic fibrosis,  amenorrhoea. The herb is used both, internally as well as externally. The present review attempts to provide comphrensive information on pharmacology, phytochemical study,toxicity, traditional uses and current research prospects of the herb.

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About Authors:
Dr.Vivek Srivastav (Ph.D)
Maxcure drugs & Pharmaceuticals Ltd.
B-7, Laxmi Tower-II, Block-C, L.S.C.
Saraswati Vihar, Delhi-110034

Gout is a kind of arthritis that occurs when uric acid builds up in the joints. Acute gout is a painful condition that typically affects one joint. Chronic gout is repeated episodes of pain and inflammation, which may involve more than one joint. Gout is a medical condition usually characterized by recurrent attacks of acute inflammatory arthritis—a red, tender, hot, swollen joint. The metatarsal-phalangeal joint at the base of the big toe is affected most often (condition also known as podagra¹), accounting for half of cases. Other joints, such as the heels, knees, wrists and fingers, may also be affected. Joint pain usually begins over 2–4 hours and during the night. The reason for onset at night is due to the lower body temperature then. Other symptoms that may occur along with the joint pain include fatigue and a high fever

About Author:
Anuradha Kaplish
M. Pharmacy (Drug discovery and drug development)
University Institute of Pharmaceutical Sciences, Panjab University,
Chandigarh-160014, India

1. INTRODUCTION
A peptic ulcer is a hole in the gut lining of the stomach, duodenum, or esophagus. A peptic ulcer of the stomach is called a gastric ulcer; of the duodenum, a duodenal ulcer; and of the esophagus, an esophageal ulcer. An ulcer occurs when the lining of these organs is corroded by the acidic digestive juices which are secreted by the stomach cells. Peptic ulcer disease is common, affecting millions of Americans yearly. The medical cost of treating peptic ulcer and its complications runs in the billions of dollars annually. Recent medical advances have increased our understanding of ulcer formation [1,2].

About Authors:
Hardwari L. Yadav, P.K. Singour, R.S. Pawar, U. K. Patil
Department of Pharmaceutical Chemistry,
VNS Institute of Pharmacy,
Neelbud, Bhopal (M.P.)

Abstract
Chalcone are the important constituent of many natural sources and have variety of biological activities. The novel chalcone derivatives isolated from the fruits of Mallotus philippinensis called mallotophilippens. The chalcones are synthesize by claisen-schmidt base catalyzed condensation of appropriate aromatic ketones or substituted aromatic ketones with benzaldehyde or substituted benzaldehydes. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants, and have also been shown to display a diverse array of pharmacological activities. Recent reports suggest antimicrobial activity of chalcones (antibacterial and antifungal), as well as antileishmanial, antimalarial, antiviral and anti-inflammatory activities of these compounds.

About Authors:Kamal Sachdeva*², Preeti Garg¹, Manmohan Singhal², Birendra Srivastava²
1. School of Pharmacy, Suresh Gyan vihar University, Jaipur
2. School of Pharmaceutical sciences,
Jaipur National University,
Jaipur, India

Abstract: The extracts of the stem bark of Jatropha curcas (Family-Euphorbiaceae) were tested for anti-diabetic activity, using blood glucose level in normal fasted rats, glucose tolerance test. Methanol: acetone: water (70:20:10) crude extract of Jatropha curcas at the dose of 100 and 300 mg/kg had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. The extract showed a significant anti- diabetic activity comparable with that of glibenclamide. These results indicate that the Jatropha curcas stem bark possess significant anti – diabetic activity.

About Author:
Rajesh Mujoriya
Sardar patel college of technology,
Balaghat, dis. Balaghat,
MP–481001,INDIA

Abstract
Ischaemic Heart Disease is a condition that affects the supply of blood to the heart. The blood vessels are blocked due to the deposition of cholesterol plaques on their walls. This reduces the supply of oxygen  and  nutrients  to the  heart musculature, which is essential for proper functioning of the heart. This may eventually result in a portion of the heart being suddenly deprived of its blood supply leading to the death of that area of heart tissue, resulting in heart attack.  
 In 1963 the Ministry of Railways carried out a survey with a view to ascertaining the number of deaths due to ischimic heart disease among railway populations in different parts of the country. The method employed was to obtain data from all the railway zones on a proforma based on W.H.O. classification 420, for arteriosclerotic, including coronary heart disease.
The epidemiology studies have provided several key points of information related to the risk of developing IHD. First, several specific risk factors for IHD have been identified. Second, evidence that these factors are closely related to environmental and life-style changes implies that risk factors are potentially alterable. Third, these studies have stimulated further consideration and investigation of the basic mechanism of atherosclerosis. Angiographic studies have indicated a direct relationship between the risk factors and the severity of coronary disease.

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About Author:
Rajesh Mujoriya
Sardar patel college of technology,
Balaghat, dis. Balaghat,
MP–481001,INDIA

Abstract
A neoplasm or tumor is a abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissue and continues in the same manner after cessation of the stimuli which have initiated it.
A malignant tumor grows rapidly and continuously, and even when it has impoverished its host and source of nutrition, still retains the potentiality for further proliferation. Besides, malignanat tumors invade and destroys neighbouring tissues and possess no effective capsule, a malignant tumors readily ulcerate and tend sooner or later dessiminate and form metastases.

About Author:
Vijay M. Waghulkar^1* (M.Pharm, D.B.M.), Dr. Supriya S. Deshpande² (M.Pharm, Ph.D), Pooja A. Kohle³  (M.Sc)
*Corresponding author
1. Lecturer, Dept of Quality Assurance
Vidyabharati, College of Pharmacy, Camp, Amravati – 444601,
Maharastra, India.

2.Professor and HOD
Punjabrao Memorial Medical College of Pharmacy,
Panchvati,  , Amravati – 444602,
Maharastra, India

3. Lecturer,Dept. Cosmectic Technology
Vidyabharati Mahavidyala, Camp, Amravati – 444601,
Maharastra, India.

Abstract
Diabetes mellitus is caused due to deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin producD.Diabetes mellitus often referred to as diabetes—is a condition in which the body either does not produce enough, or does not properly respond to, insulin, a hormoneproduced in the pancreas. Insulin enables cells to absorb glucose in order to turn it into energy. This causes glucose to accumulate in the blood, leading to various potential complications.

To overcome such complication Indian scientist have develop new techniques for diabetics i.e. single shot insulin which ,  is very essentials, blessful, create new ray of hope to the patients of diabetics ,give relief upto 120 days.