Preparation and Evaluation of Fast Dissolving Tablets for an Selected Drug
About Author: Vipul Kumar Tyagi (B.Pharm)
Shri Gopichand College Of Pharmacy,
Ahera (Baghpat)
Introduction
Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and h case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance. To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets; (ODT) has emerged as alternative oral dosage forms. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds. A fast dissolving tablet was prepared by using various super disintegrants taken in different concentration (10%, 12%, and 14%) and one control batch is prepared without disintegrants designated as four different groups of formulations(F-1,F-2,F-3 and F-4) . Chemical incompatibility studies confirmed that there is no interaction between drug and excipients used in the formulations. All the batches are prepared by direct compression method. Effect of disintegrants on the disintegration behaviour was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay.Direct compression method involves the incorporation of superdisintegrants in to the formulation. Direct compression does not require water or heat during formulation procedure and it is well suited for moisture and heat sensitive drugs. Fast dissolving tablets have so many advantages over liquid dosage form and conventional tablets. Fast dissolving tablet is suited for tablets which are undergoing first pass effect, and it is increase their bioavailability. A fast-dissolving drug delivery system, in most cases, is a tablet that dissolves or disintrigrants in the oral cavity without the need of water or chewing. Most fast-dissolving delivery system films must include substances to mask the taste of the active ingredient. This masked active ingredient is then swallowed by the patient’s saliva along with the soluble and insoluble excipients. These are also called melt-in-mouth tablets, repimelts, porous tablets, oro-dispersible, quick dissolving or rapid disintegrating tablets.
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