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Pharmacological Investigation of the Plant Prunus Amygdalus (Batsch) for its Anti-ulcer
About Author: Devendra Kumar1*, Durga Prasad Dash1, Shushank Dixit2, Pragya Seth3
Department of Pharmaceutical technology,
1Sri Satya Sai collage of Pharmacy (Sehore),
2NH-58, Bagpath road bypass, MIET, Meerut,
3Laxmi Narayan College of Pharmacy, Bhopal
Abstract
This study has been undertaken to investigate the effect of methanolic extract of almond nuts of Prunus amygdalus (batsch.) on pylorus ligation gastric ulcers in Wistar rats. Treatment with Prunus amygdalus extract of (200 mg/Kg bodyweight, 400 mg /Kg body weight) and ranitidine (50 mg/ Kg body weight) for 1 hr to the Ethanol and rats Pylorus ligation were given and absorb the acid parameters. The present study provides a strong evidence of antiulcer activity of Prunus amygdalus extract against gastric lesions. The antiulcer activity is recognized by a reduction in acid-secretary parameters (i.e. total and free acid), gastric volume and ulcer score suggesting that acid inhibition accelerates ulcer healing, thereby strengthening of mucosal barrier. Administration of Prunus amygdalus (200 mg/kg & 400mg/kg p.o.) increased CAT, and GSH levels as compared to the negative control group, which suggests its efficacy in preventing free radical-induced damage. However, significant increase was observed all doses but in 400mg/kg were better results. In this present study was showed that there was present a significant protection for Hexosamine in all treated groups in compare to negative control group. The LPO results in showed that there was significance level difference present in negative control group and all other group that indicated that lipid peroxides enzyme was higher in vehicle treated group. Ulcer score is the counting of spots and severity of damage in gastric part by any moiety such as ethanol. Single drug treatment (200 mg/kg and 400mg/kg of P.A.E.) was effective up to a significant level (P<0.05) in compare to negative control group. Volume of gastric juice indicate the secretions of gastric fluid and it is higher in negative control group and all drug treated group was effective in relation to negative control group (P <0.05).
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