Lucknow

Medybizpharma is incorporated since 2009 focussed on distribution of Super Specialty products cross PAN India with delivery capabalities at 17 locations.

Post: Pharmacist-1 position

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ABOUT AUTHORS:
Vinit Raj*, Amit Rai, Deepak Kumar and Vinod Kumar
Department of Pharmaceutical Sciences,
Babasaheb Bhimrao Ambedkar University (A Central University),
VidyaVihar, Raebreli Road, Lucknow, Uttar Pradesh, 226025, India
*raj.vinit24@gmail.com

ABSTRACT
Epilepsy is a common brain disease that is characterized by recurrent and spontaneous seizures that result from abnormal and excessive synchronization of neuronal activity. Whereas, accumulation of Ca⁺⁺ in presynaptic terminals, leading to improved neurotransmitter release. In additional, depolarization-induced inauguration of the NMDA subtype of the excitatory amino acid receptor, which causes more Ca⁺⁺ influx and neuronal activation. The main aim of this study to focus on the deactivation of Ca⁺⁺ influx and prevent the augmentation of neuron activation. However, we performed molecular modeling of  novel 1,3,4-thiadiazole derivatives keeping in view structural requirement of pharmacophore and Quantitative structure activity relationship (QSAR) and evaluated in silico anticonvulsant activity. Docking procedures allow virtually screening a database of compounds and predict the strongest binder based on various scoring functions. In the docking study, targeted ligand  produced significantly affinity with the calcium channel receptor which is slightly higher than the phenytoin drug. A computational study was also carried out including prediction of pharmacokinetic properties, toxicity and bioactivity studies. All above parameter was calculated which exhibited slightly excellent compared than standard Phenytoin drug. The above observation suggested that these compounds would serve as better lead for anticonvulsant screening for future drug design perspective.

Central Institute of Medicinal and Aromatic Plants, popularly known as CIMAP, is a frontier plant research laboratory of Council of Scientific and Industrial Research (CSIR).

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Post: Medical Repersentative

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CSIR- National Botanical Research Institute (NBRI), Lucknow, a premier plant science research institute under Council of Scientific & Industrial Research (CSIR), is involved in multidisciplinary R&D programmes of both basic and applied nature across scientific disciplines for economic, environmental and societal benefits for the people of India.

Applications are invited in the prescribed proforma along with self attested copies of certificates in support of educational qualifications, experience, date of birth and caste for filling up the posts on purely temporary basis. The last date of receipt of application is 21 days from the date of publication including the date of publication of this recruitment notice.

The National Institute of Pharmaceutical Education and Research (NIPER) has been created as a centre of excellence for higher education, research and development in pharmaceutical sciences. NIPER, Rae Bareli at ITI campus, Rae Bareli under the mentor Institute of CSIR - Central Drug Research Institute, Lucknow invites eligible candidates for following positions on purely temporary basis on contract initially for a period of 1 year which can be extended further.