Articles

21 November 2017

PATHOPHYSIOLOGY OF TUBERCULOSIS: AN UPDATE REVIEW

ABOUT AUTHORS
Devender Sharma*¹, Deepika Sarkar¹
¹Hi – Tech College of Pharmacy, Chandrapur, Maharashtra (India)
^*sdevender350@gmail.com
{ DOWNLOAD AS PDF }

ABSTRACT
Tuberculosis is a hypersensitive granulomatous infectious disease caused by Mycobacterium Tuberculosis (M.TB).In India 40% people are affected by T.B. So need of knowledge about T.B. and pathophysiology of T.B. to people or society. Pathophysiology means, when a human being or animal being suffering from a disease this is because deranged or change in function on that organ or human body. Infection is caused by air- borne droplets of organisms person to person. The main object of this review is how to diagnose and how it is cure or treat. It is diagnosed by PPD, IGRA, Sputum studies, X-rays and Biopsies. Mostly antibiotics are preferred for the first treatment.
27 June 2017

HUMAN GENOME SCIENCE, A NEW FACE OF PHARMACEUTICAL SCIENCE: A REVIEW

ABOUT AUTHORS
Tahseen Sameena*1, Prathima Patil1, S.P.Sethy*1
1Department Of Pharmaceutics.
Azad College of Pharmacy
Moinabad-Chilkur Road , Hyderabad- India
* tahseensameena1992@gmail.com
{ DOWNLOAD AS PDF }

ABSTRACT: -
The Human Genome Project (HGP) refers to the international 13‐year effort, formally begun in October 1990 and completed in 2003, to discover all the estimated 20,000–25,000 human genes and make them accessible for further biological study. Another goal of this project was to determine the complete sequence of the 3 billion DNA subunits (bases in the human genome). As part of the HGP, parallel studies were carried out on selected model organisms such as the bacterium E.coli and the mouse to help develop the technology and interpret human gene function. The DOE Human Genome Program and the U.S National institute of Health (NIH) National Human Genome Research Institute (NHGRI) together sponsored the U.S.Human Genome Project.”
23 September 2014

Council of Scientific and Industrial Research Sponsored Two Days National Level Seminar on Role of Pharma Clinic in Health care Profession of Indian Rural Area at P.S.G.V.P. Mandal's College of Pharmacy

P.S.G.V.P. Mandal's College of Pharmacy has the privileges of identifying as an exclusive pharmacy college in whole of Satpuda hill ranges and remote region. The college offers D. Pharm., B. Pharm. and M. Pharm. (Quality Assurance and Pharmaceutics) Course.
26 May 2014

A REVIEW OF NATEGLINIDE IN THE MANAGEMENT OF TYPE 2 DIABETES

{ DOWNLOAD AS PDF }
20 January 2014

BRIEF CONCEPT OF VALIDATION & CALIBRATION

{ DOWNLOAD AS PDF }

About Authors:
Nirav.R. Soni
M.Pharm, A-One Pharmacy College,
Anasan, Ahmedabad-382330, India
nirav_sonic@yahoo.com

Abstract:
Validation is a important part of Analytical as well as Bio-Analytical Method. The procedures involved in checking data or programs for correctness, compliance with standards and conformance with the requirement specifications. It is establishing documented evidence, which provides high degree assurance that a specific process will consistently produce a product meeting its predetermined specification and quality characteristics. Calibration is totally differ from Validation But it is an integral part of validation.
17 January 2014

DRUG THERAPY PROBLEMS: A REVIEW OF LITERATURE

About Authors:
Languluri Reddenna¹*, Sree Nagavalli K²
¹Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India-516003
²Department of Pharmacy Practice, S.J.M College of Pharmacy, Chitradurga, Karnataka, India-577502
*reddennapharmd@gmail.com
16 January 2014

MICROSPHERES AS HYDRODYNAMICALLY BALANCE SYSTEM

{ DOWNLOAD AS PDF }

About Authors:
Rohit Kumar Ahuja*¹, Surendra Singh Saurabh¹, Poonam Choudhary¹, Aniket Singh Chouhan¹, Kamal Singh Rathore²
¹ Lachoo Memorial College of Science and Technology (Pharmacy Wing) Sector-A, Shastrinagar, Jodhpur (Raj.) 342003, IND.
²BN Institute of Pharmaceutical Sciences, Udaipur (Raj.) 313002, India
rohitahuja1111@gmail.com

Abstract:
To build up an oral drug delivery system, it is essential to optimize both release rate of drug and residence time of system within gastrointestinal tract. In oral path difference in gastric physiology such as gastric pH and motility display variability on gastric residence time (GRT) and drug delivery actions. Several approaches are currently utilized in the prolongation of the GRT including hydrodynamic balance systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices.One such approach is Floating Microspheres (Hollow Microspheres). Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. These microspheres are characteristically free flowing powders made of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Gastro-retentive floating microspheres are low-density systems that have sufficient buoyancy to float over gastric contents and remain in stomach for prolonged period. The drug is released slowly at desired rate resulting in increased gastric retention with reduced fluctuations in plasma drug concentration. Floating microspheres improve patient compliance by decreasing dosing frequency and better therapeutic effect of short half-life drugs can be achieved. Floating microspheres are characterized by their micromeritic properties such as particle size, tapped density, compressibility index, true density and flow properties including angle of repose, scanning electron microscopy, in vitro floatability studies, in vitro drug release studies and stability studies etc.
15 January 2014

AN INSIGHT TO IN-SITU GEL FORMING STOMACH SPECIFIC DRUG DELIVERY SYSTEM

{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Deepak Kumar*, Palak Kapoor
Shoolini University,
Solan, Himachal Pradesh
deepakkaushik354@gmail.com

ABSTRACT:
The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. To provide controlled delivery of drugs novel drug delivery systems have been developed. Different systems have been developed to increase the gastric residence time viz. floating system, mucoadhesive, high density, expandable. Among all oral dosage forms, liquid orals are more prone to low bioavailability due to fast transit time from stomach to duodenum. Sustained/Controlled delivery can be achieved by decrease in the transit time of the dosage form. This can be augmented by an approach of liquid in-situ gelling system. These in-situ formulations are the drug delivery systems that are in sol form before administration in the body, but when administered, undergo gelation, in-situ, to form a gel. Formation of gel depends on various factors viz. temperature modulation, pH change, presence of ions, ultra-violet irradiation, from which drug releases in a sustained and controlled fashion. Different polymers which can be used for formation of in-situ gel include gellan gum, alginic acid, xyloglucan, pectin, chitosan, poly-caprolactone, poly-lactic acid, poly-lactic-co-glycolide. This article presents a detailed review of introduction, approaches to achieve in situ gelling system, polymers used, evaluation parameters, advantages of in situ gelling system.
14 January 2014

MANAGEMENT OF ASTHMA: ROLE OF CLINICAL PHARMACIST

About Authors:
Languluri Reddenna¹*, Sree Nagavalli K²
¹Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India-516003
²Department of Pharmacy Practice, S.J.M College of Pharmacy, Chitradurga, Karnataka, India-577502
*reddennapharmd@gmail.com
12 January 2014

SYNTHESIS AND ANTICANCER ACTIVITY OF FLAVONE DERIVATIVES AGAINST ESTROGEN DEPENDENT CANCERS BY RATIONAL APPROCH

{ DOWNLOAD AS PDF }

About Authors:
Vanraj Thakor¹*, Jalpa Kher², Fenil Bhayani¹, Bhavini Atodaria¹, Malleshappa Noolvi¹
¹Shree Dhanvantary college of pharmacy, Kim, Surat, Gujarat, India.
²Ashok & Rita Patel institute of Biotechnology, New Vallabh Vidyanagar, Gujarat, India
vanraj7777@gmail.com, jkher3333@gmail.com

Abstract
Aromatase and 17-ßHSD inhibitors are main target of pharmacological interest for the treatment of estrogen dependent cancers. Chalcones, Coumarins, Flavones, Isoflavones have been reported for such inhibition and are used for treatment of breast tumors. So in this topic, Flavone derivatives containing Imidathiadiazole, Thiadiazole, Triazole and benzimidazole hetrocycles synthesised by using simple laboratory reagents like 2-Hydroxy Acetophenone and 4-Hydroxy Benzaldehyde to convert chalcone leads to formation of Flavones by cyclazation using Microwave and followed by attachment of different hetrocycles to form Flavone derivatives and charactrarized by IR, ¹H NMR, ¹³C NMR spectroscopy and elemental analysis. These Flavone derivatives found to exhibit moderate to high inhibitory activity against Estrogen dependent cancers.