About Author:
RAHUL SINGH,
M.PHARMA (Pharmaceutics),
Shri Rawatpura Sarkar Institute Of Pharmacy,
Kumhari, Distt-Durg , Chhatishgarh, India
rahulbaba92@yahoo.in (9039469951,9993319135)
ABSTRACT :
Diclofenac Sodium, being NSAID, its oral administration restricted due to its inherent problems. Hence in the present study, attempt has been made to design oral sustained release once daily matrix tablets of Diclofenac Sodium using combination of hydroxyl propyl methyl cellulose (HPMC) & PEG 6000 and to study the effect of various process and formulation variables like polymer properties and polymer viscosity on in-vitro release of drug.
Diclofenac sodium dose ranges from 100-200 mg twice or thrice daily. So there is a commercial utility of controlled release once daily tablets of Diclofenac sodium for better therapeutic efficacy, patient compliance and other advantages.