Miscellaneous Articles

8 May 2012

Burning issue - Present status of Pharmaceutical Industries

“Recent acquisition of Indian generic drug companies by MNCs has increased fears that the price of low-cost generic drugs will rise in India. The buy-outs will reduce domestic availability of many essential medicines; point out an internal assessment of the health ministry, Government of India. It is ironic that despite India supplying quality generic drugs around the world, the country has concerns about sufficient domestic drug supply and vaccines security. With the increasing acquisition of Indian companies by overseas drug corporations, there is a pressing need to rethink India’s drug strategy”. This statement was released by government of India before few months. Now what global honchos think about India?
26 April 2012

View - There is no hope for the perfect research work

Research is an important tool for the human society. It is used to demystify the unsolved enigma of the nature. Homo sapiens are the most intelligent creature who has ever dominated the earth by his Intellectual reasoning and capacity. As we are living in 21^st century which is known as modern age. So it is vital to do research to discard the age-old hypothesis and to establish clear/concise conceptions about a particular issue which can makes our lives safer in the planet.
23 April 2012

NEED OF PHARMACOECONOMICS IN INDIAN HEALTH CARE SYSTEM: A BRIEF REVIEW

About Authors:
Hinchagri S S ^1*, Halakatti P K², Devar S B², Biradar B S², Kankanwadi S K², Patil S D²
^1. HKES’s College of Pharmacy, Sedam Road, Gulbarga, Karnataka, India
^2. HSK College of Pharmacy, BVVS’s Campus, Bagalkot, Karnataka, India
*shivanand.hinchageri95@gmail.com

Abstract:
In India, nearly 3.1 million households below the poverty line and those are unaffordable for private health care. Cost of medicines are growing constantly as new medicines are marketed and are under patent law, preference of drug therapy over invasive therapy, and the irrational drug prescription. In a developing country like India 85% of total health expenditure is financed by house-hold, out-of–pocket expenditure. The proportion of insurance in health-care financing in India is very low. Many poor people frequently face a choice between buying medicines or buying food or other necessities due to limited resources and high pricing of drug. So medicine prices do matter. The main objective of study is to show the importance of pharmacoeconomic evaluation in Indian health care. Methods to be used for pharmacoeconomic evaluation are Cost-effectiveness analysis, Cost minimization analysis, Cost-benefit analysis and Cost-utility analysis. Review of pharmacoeconomic evaluation sample studies shows the pharmacoeconomics became more important 1. To find the optimal therapy at the lowest price. 2. Numerous drug alternatives and empowered consumers also fuel the need for economic evaluations of pharmaceutical products. 3. The use of economic evaluations of alternative healthcare outcomes. 4. Healthcare resources are not easily accessible and affordable to many patients; therefore pharmacoeconomic evaluations play an important role in the allocation of these resources. The study concludes that in India the pharmacoeconomic evaluation is essential to optimal therapy at lowest price, alternative treatment plans, which help the poor and middle class Indians to obtain well health care services.
13 April 2012

COLOURING AGENTS USED IN FOOD PRODUCTS

Abstract
Food colourants have been much important in food product manufacturing. Food and color additives are strictly studied, regulated and monitored. Federal regulations require evidence that each substance is safe at its intended level of use before it may be added to foods. Furthermore, all additives are subject to ongoing safety review as scientific understanding and methods of testing continue to improve. A color additive is any dye, pigment or substance which when added or applied to a food, drug or cosmetic, or to the human body, is capable (alone or through reactions with other substances) of imparting color. FDA is responsible for regulating all color additives to ensure that foods containing color additives are safe to eat, contain only approved ingredients and are accurately labeled. Certified colors are synthetically produced (or human made) and used widely because they impart an intense, uniform color, are less expensive, and blend more easily to create a variety of hues. Color is added to food for one or more of the following reasons:
(1) to replace color lost during processing,
(2) to enhance color already present,
(3) to minimize batch-tobatch variations, and
(4) to color otherwise uncolored food.
3 April 2012

WHO Guidelines for Quality Standardized Herbal Formulations

a.Quality control of crude drugs material, plant preparations and finished products.
b.Stability assessment and shelf life.
c.Safety assessment; documentation of safety based on experience or toxicological studies.
d. Assessment of efficacy by ethnomedical informations and biological activity evaluations.
29 March 2012

REGULATORY ASPECT OF CAPA IN QUALITY MANAGEMENT SYSTEM

ABOUT AUTHOR:
Devesh Sharma
M.Pharm-DRA
School of Pharmaceutical Sciences, JNU, Rajasthan
Trainee, Chemist, Ind-swift labs ltd, Mohali, (punjab)
devesh.m.pharmdra@gmail.com

ABSTRACT:
Corrective and Preventive Action (CAPA)is a concept within Good Manufacturing Practice (GMP). CAPA focuses on the systematic investigation of discrepancies (failures and/or deviations) in an attempt to prevent their recurrence. To ensure that corrective and preventive actions are effective, the systematic investigation of the failure incidence is pivotal in identifying the corrective and preventive actions undertaken. CAPA is part of the overall quality management system.CAPA is of paramount importance to the FDA. According to FDA documents CAPA accounts for 30-50% of FDA-483 forms issued for non compliance.
23 March 2012

A REVIEW ARTICLE ON RESEARCH & DEVELOPMENT OF PHARMACEUTICAL MEDICINE WITH SPECIAL EMPHASIS ON PREFORMULATION (A NEED FOR DOSAGE FORM DESIGN)

About Authors:
Kapil Sharma^*, Priyanka Sharma^**
^*M.Pharm, Yaresun Pharmaceutical Pvt Ltd, India
^**M.sc, Yaresun Pharmaceutical Pvt Ltd,
Rajasthan, India.

Aim: - To search Pharmaceutical medicine (New, Safe & Effective) to enhance health and benefits of patients & community.

Trends:-Usually search a pharmaceutical medicine is starting from “Drug Discovery and Drug Development” (D4) or Pharmaceutical R&D.
D4 is very long, very costly and very complex process, so mostly companies put together D4 plan. Drug Discovery and Drug Development is the treds of searching a Pharmaceutical medicine
18 March 2012

STEM CELLS REGULATION

MOLECULES INVOLVED IN REGULATION OF STEM CELL DIFFERENTITIATION
Cell adeshive molecule E_cadhedrin which replaces oct 4signalling molecule there by converting normal somatic cell into pluripotent
15 March 2012

EPIDEMIC OF ACCIDENTAL DEATHS AND EMERGENCE OF EMERGENCY MEDICINE IN INDIA

About Authors:
S Hamza*¹, Dr Tanveer Aalam², Dr Asma^3

1^*Assistant Professor, Department of Pharmacology,
Shree M V Shah Pharmacy college,
Gajan, Modasa: 383315, Gujarat.
² Department of Emergency Medicine,
Apollo hospitals International Ltd,
Bhat GIDC estate, Gandhinagar: 382428, Gujarat.
³Medical Officer, Civil Hospital,
Ahmadabad: 380 002. Gujarat, India

ABSTRACT:
India suffers from the highest number of deaths - around 1,05,000 in absolute terms annually- due to road accidents in the world owing to poor infrastructure and dangerous driving habits according to the World Health Organisation¹. Calling road fatalities an "epidemic" that will become the world's fifth biggest killer by 2030². It is said that 90% of deaths on the world's roads occur in low and middle-income countries (21.5 and 19.5 per lakh of population, respectively) though they have just 48% of all registered vehicles.

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7 March 2012

Stevia rebaudiana : a ray of life for diabetics

Stevia rebaudianais a well known medicinal herb contains antibacterial, antifungal, anti-inflammatory, anti-viral, anti-yeast, cardiotonic diuretic and hypoglycaemic properties. This herb has been used in Ayurveda in India since centuries. Stevia is a perennial herb belonging to the family Asteraceae, is one of the most valuable tropical medicinal plant. Leaves of this plant produce zero calorie, high potency sweetener and substitute to sucrose, being about 300 times sweeter than sucrose. The compounds, named stevioside and rebaudiocide give stevia its taste. In India number of diabetic people in the age group of 25-45 is about 15% and is also increasing at an alarming pace. In addition, India is the largest consumer of sugar in the world. So stevia is attaining attention in Indian market as a healthy alternative sweetener to sugar. Stevia has no calcium cyclamate, no saccharim, no aspartame and no calories. It is safe for diabetics, as it does not affect blood sugar levels and have no neurological or renal side effects.