Mehsana

9 October 2013

Opening for B. Pharm, M.Pharm as Regulatory Affairs Officer (2 posts) in PAR Laboratories

As a dedicated manufacturer and marketer of Hormone products, the Company concentrated on the niche areas of operations. With its beginnings in Mumbai, PAR Laboratories has been providing quality hormones and contraceptive products to various markets around the world.
In recent months, the Company has been transitioning to position itself for a substantial growth. PAR Laboratories’ acquisition by another pharma group with vast International experience opened the doors of the company to many markets. Along with it came the access to the group’s complete Research and Development facility in Navi Mumbai. This is quickening our ability to bring new hormonal products and better formulations to the market place rapidly. Over the years, PAR Laboratories has been able to identify several new product opportunities which are now in a state of development and continuous improvements.

Post: Regulatory Affairs Oficer - 2
19 August 2013

Walk in interview for Medical Representative in Ajanta Pharma

Ajanta Pharma Limited is an emerging, global pharmaceutical company with proven capabilities in the areas of product research, manufacturing & marketing.
11 August 2013

Vacancies for Regional Sales Manager, Field Sales Manager, Medical Representative in Juggat Pharma

We are happy to invite you to scale new career heights in healthcare & pharmaceutical sales and marketing. Jagdale Lifesciences - the lifesciences division of Jagdale Industries Ltd., Bangalore, offers excellent openings for interested suitable candidates in sales and marketing. Jagdale Lifesciences is the sister division of Juggat Pharma, Bangalore, which is the flagship division of JIL. The key Juggat Pharma brands include Botropase, BotroClot, ORS-L, and Dart.
30 July 2013

H2S : REVOLUTIONARY SCIENTIFIC MIRACLE AS A GASOTRANSMITTER AT MAXIMUM POTENTIAL IF USED WISELY

ABOUT AUTHORS:
Krishna J. Kathawala¹*, Gaurav L. Ninama¹, Ankitkumar Y. Parikh¹, Krupali V. Upadhyay²
¹A. R. College of Pharmacy & G. H. Patel Institute of Pharmacy B/H. B & B Polytechnic College, Vallabh Vidyanagar - 388 120, Gujarat, India.
²Shree Satsangi Saketdham “Ram Ashram” group of Institution, At. & Post. Vadasma, Tal. & Dist. Mehsana, Gujarat – 382708, India.
*krishna.kathawala@gmail.com

ABSTRACT
Nitric oxide (NO) and Carbon monoxide (CO) are the reputed neurotransmitters involved in the regulation of vascular tone. H₂S, which synthesized from L-cysteine, can play more vital role as Gasotransmitters compare to NO and CO. H₂S have a role as a stimulator of ATP-sensitive potassium channels (KATP-channels) in the vascular smooth muscle cells, neurons, cardiomyocytes and pancreatic β-cells. H₂S also minimize the toxic effect by reacting with reactive oxygen and/or nitrogen species and attenuating their physiological functions. H₂S have a unique feature of not to stimulate soluble guanylate-cyclase like other Gasotransmitters. H₂S plays a critical role in the regulation of vascular tone, neurotransmission, insulin secretion, and myocardial contractility. Recent studies showed that, in various animal models of arterial and pulmonary hypertension, Alzheimer’s disease, gastric mucosal injury and liver cirrhosis had H₂S deficiency which defines the significance of H₂S. Exogenous H₂S alleviates myocardial dysfunction associated with the ischemia/reperfusion injury with reducing the damage of gastric mucosa generated by anti-inflammatory drugs. H₂S had also some drawbacks like every coin has two sides. Excessive production of H₂S may contribute to the pathogenesis of inflammatory diseases, septic shock, cerebral stroke and mental retardation in patients with Down syndrome, and reduction of its production may be of potential therapeutic value in these states. Preclinical evidence is provided to show that H₂S releasing derivatives of several NSAIDs, including Diclofenac and Indomethacin indeed represent excellent gastrointestinal safety and are more potent than the parent drugs as anti inflammatory agents. Derivatives of anti-inflammatory drugs other than NSAIDs (e.g. mesalamine) have also been shown to be significantly improved over the parent drug in many respects. So, H₂S can be Revolutionary scientific miracle as a gasotransmitters at maximum potential if the drawbacks are minimize by cutting edge solution.
8 April 2013

RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND DESLORATADINE IN COMBINED DOSAGE FORM

ABOUT AUTHORS:
Rima M. Bankar*, Dipti B. Patel
Department of Pharmaceutical Analysis,
Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University,
Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
*rima.banker@yahoo.com

ABSTRACT
A novel, precise, accurate and rapid isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method was developed, optimized and validated for simultaneous determination of Montelukast Sodium and Desloratadine. The method showed adequate separation for Montelukast Sodium and Desloratadine and best resolution was achieved with ACE 5 C18 column (150 mm × 4.6 mm i.d, 5 μm particle size) using Acetonitrile-Methanol-Water (15:80:5, v/v) as a mobile phase at a flow rate of 1.0 ml/min and wavelength of 283 nm. The calibration curves were linear over the concentration ranges of 5-50 μg/ml for Montelukast Sodium and Desloratadine. The limit of detection (LOD) and limit of quantification (LOQ) for Montelukast Sodium were 0.33 and 1.01 μg/ml while for Desloratadine were 0.10 and 0.31 μg/ml, respectively. All the analytes were separated in less than 6.0 min. The proposed method could be applied for routinelaboratory analysis of Montelukast Sodium and Desloratadine in pharmaceutical dosage form. Methods were validated statistically and recovery studies were carried out. The proposed methods have been applied successfully to the analysis of cited drug either in pure form or in synthetic mixture of both drugs with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

(adsbygoogle = window.adsbygoogle || []).push({});
4 April 2013

SIMULTANEOUS ESTIMATION OF EPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM BY RATIO SPECTRA DERIVATIVE SPECTROPHOTOMETRY METHOD IN SYNTHETIC MIXTURE

ABOUT AUTHORS:
Rinku B Patel^*1, Paresh U Patel², Bharat G Patel³, Anil C Patel²
¹Department of Pharmaceutical Analysis, Centre For Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
²Department of Quality Assurance, Centre For Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
³Aspee college of Home Science and Nutrition, S.D.Agricultural University, S.K.Nagar-385506, Banaskantha, Gujarat, India.
*rinkupatel5890@gmail.com

ABSTRACT
Simple, accurate, precise, and sensitive ratio spectra derivative spectrophotometric method for simultaneous estimation of Eperisone hydrochloride (EPE) and Diclofenac sodium(DIC) in synthetic mixture have been developed and validated. The ratio derivative spectroscopic method involves measurement of first derivative amplitude of ratio spectra at 247 nm for EPE and 218.4 nm for DIC as two wavelengths for estimation. Beer's law is obeyed in the concentration range of 2-18 μg/ml for both EPE and DIC. LOD values for EPE and DIC are found to be 0.0634 μg/ml and 0.5386 μg/ml, respectively. LOQ values for EPE and DIC are found to be 0.1921 μg/ml and 1.6321 μg/ml, respectively. The method was validated statistically and recovery studies were carried out. It was found to be accurate, precise and reproducible. The method was applied to the assay of the drugs in synthetic mixture, which were found in the range of 98.0% to 102.0% of the labeled value for both Eperisone hydrochloride and Diclofenac sodium. Hence, the method herein described can be successfully applied in quality control of synthetic mixture.

(adsbygoogle = window.adsbygoogle || []).push({});
4 April 2013

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Ibuprofen and Chlorzoxazone in Synthetic Mixture

ABOUT AUTHORS
Anil C. Patel*, Dr Paresh U. Patel , Rinku B. Patel
Department of Quality Assurance, S. K. Patel College of Pharmaceutical Education and Research,
Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
*anilpatel002@gmail.com

ABSTRACT
A novel, precise, accurate and rapid isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method was developed, optimized and validated for simultaneous determination of Ibuprofen and Chlorzoxazone. The method showed adequate separation for Ibuprofen and Chlorzoxazone and best resolution was achieved with ACE 5 C18 column (150 mm × 4.6 mm i.d, 5 μm particle size) using Acetonitrile-Phosphate buffer pH 3.5 - Methenol (20:20:60, v/v; pH adjusted to 3.5 with O-phosphoric acid and TEA(Tetra ethyl amine) as a mobile phase at a flow rate of 0.7 ml/min and wavelength of 221 nm. The calibration curves were linear over the concentration ranges of 2-30 μg/ml for Ibuprofen and Chlorzoxazone. The limit of detection (LOD) and limit of quantification (LOQ) for Ibuprofen were 0.96 and 2.92 μg/ml while for Chlorzoxazone were 0.69 and 2.09 μg/ml, respectively. All the analytes were separated in less than 6.0 min. The proposed method could be applied for routinelaboratory analysis of Ibuprofen and Chlorzoxazone in pharmaceutical dosage form. Methods were validated statistically and recovery studies were carried out. The proposed methods have been applied successfully to the analysis of cited drug either in pure form or in synthetic mixture of both drugs with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.
12 March 2013

SPECTROPHOTOMETRIC ESTIMATION OF TOLPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE BY DUAL WAVELENGTH METHOD

ABOUT AUTHORS:
Hiral H. Patel*, Paresh U. Patel,
Department of Pharmaceutical Analysis, Center for Health and Science Studies,
Ganpat University, Ganpat Vidyanagar – 384012,
Mehsana, Gujarat, India.
*patel.hiral2210@gmail.com

ABSTRACT
This method describes simple, sensitive, rapid, accurate, precise and economical derivative spectroscopic methodfor the simultaneous determination of tolperisone hydrochloride (TOL) and diclofenac sodium (DIC) in bulk and synthetic mixture. In this study, dual wavelength spectroscopic method was used for simultaneous determination of tolperisone hydrochloride and diclofenac sodium using the absorbance difference at two wavelengths. The absorbance differences of 257 nm and 306.20 nm were selected for the estimation of TOL and the absorbance differences of 243.40 nm and 265.40 nm were selected for estimation of DIC. The method was found to be linear (r2>0.999) in the range of 2- 18 μg/ml for tolperisone hydrochloride. The linear correlation was obtained (r2>0.997) in the range of 2- 18 μg/ml for diclofenac sodium. The limit of determination was 0.66 and 0.27 μg/ml for tolperisone hydrochloride and diclofenac sodium respectively. The limit of quantification was 2.00 and 0.83 μg/ml. The method was successfully applied for simultaneous determination of tolperisone hydrochloride and diclofenac sodium in binary mixture.
22 February 2013

AICTE SPONSORED Two Weeks Faculty Development Programme on “Recent Advances in Parentral Drug Delivery Systems & Technology” @ Ganpat University
30 January 2013

INSIGNIFICANT EFFECT OF SUPERPOROUS HYDROGEL PARTICLES AS A SUPERDISINTEGRANTS IN FAST DISPERSIBLE TABLETS OF ACECLOFENAC

About Authors:
Dr. HV Chavda^1*, Ms. SK Patel¹, Dr. CN Patel¹,
¹Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat-384001, India.
^*hvchavda@sspcmsn.org

ABSTRACT
Background: In present investigation an attempt has been made to formulate a fast dispersible formulation of aceclofenac using three different superdisintegrants. The role of superporous hydrogel particle as a superdisintegrant was checked for its further future applications. Materials and Methods: The selection of superdisintegrants viz. poly (Acrylamide-co-Acrylic acid) superporous hydrogel particles, cross carmellose sodium and starch 1500 were done using the simplex lattice design. Tablet formulations were prepared using direct compression technique and evaluated for hardness, weight variation, friability, drug content, dispersion time, wetting time, water absorption ratio and in vitro drug release studies. Results and Discussion: The dispersion time of all formulation showed less than 21 second. Superporous hydrogel particles did not showed significant improvement in dispersion time compared cross carmellose sodium and starch 1500. The in vitro drug release from batch F7, tablets containing equal proportions of superdisintegrants showed fast dispersion and fast release compared to other batches. Batch F7 was stable for the period of six months at 40 ^oC / 75 %RH. Conclusions: Combination of three superdisintegrants was more suitable in fast dispersible tablet formulation of aceclofenac. The superporous hydrogel particles showed equivalent effect as a superdisintegrant, however process complexity of its preparation suspects its role or an option as a superdisintegrant in fast dispersible or immediate release formulations.