Dehradun

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ABOUT AUTHORS:
Badola Ashutosh,* Nishu Sharma
Shri Guru Ram Rai Institute of Technology & Science ( SGRRITS ),
Dehradun 248001, Uttarakhand , India
*ashutosh.badolam.pharma@gmail.com

ABSTRACT:
Controlled release local drug delivery systems offer advantages compared to systemic dosage forms for periodontitis. The objective of this research was to design and evaluate sustained release dental films containing drug in a non-biodegradable polymer for targeted delivery of the drug. The polymer ethyl cellulose was used in the formulation of dental films. The dental film was then evaluated for various parameters like thickness, folding endurance, and weight variation, and content uniformity, in vitro and in vivo study. Drug release profile of the dental film showed that the film exerted an initial burst release followed by a sustained release of the drug and the drug release was well above the minimum inhibitory concentration throughout the time of study. The release data obtained were subjected for release kinetics study. The study suggested that the non-biodegradable based dental film is a potential local drug delivery device for the treatment of periodontitis.

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ABOUT AUTHORS:
Dr. N.V. Satheesh Madhav, Girish Dwivedi^*
Dehradun Institute of Technology, Faculty of Pharmacy
Village Makkawala, Mussoorie Diversion Road,
Dehradun-248009
^*Girish10.dwivedi@yahoo.com

ABSTRACT
Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for site specific and systemic treatment. The review is prepared with an aim to discuss about the technical, physiological, and efficacy aspects of the novel pulmonary route of drug targeting and different delivery devices such as metered dose inhalers (MDI), dry powder inhalers (DPI), nebulizers, etc. The review also focuses on the mechanisms of pulmonary drug administration along with compatibility of the excipients employed, devices used, techniques of particulate dosage production, evaluation and advancements in the pulmonary drug delivery. It can be concluded from whole study that different pulmonary delivery system possesses certain specificity for dosage formulations and serves as an important tool to deliver drugs to the target site.

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