About Author:
*Seema Singh1, Sandeep Kumar Singh2
1Department of Pharmacy, Northern India Engineering College, Lucknow (U.P.) India
2Department of Pharmaceuticals Sciences, Dr. H S Guar University Sagar (M.P.), India
*seema_b.pharm@rediffmail.com
Abstract:
Present study is aimed to delineate a co-relation between status of anti-oxidant enzymes, lipid peroxidation products with severity of Pregnancy Induced Hypertension (PIH) and cervical dysplasia. The study has been done on 66 patients out of whom 14 were normal pregnancy and had no disease, 31 patients of PIH and 21 patients having cervical dysplasia gr. I-II. Enzymatic activities of Superoxide dismutase (SOD), Catalase (CAT), vitamin C and vitamin E and malonaldehyde levels (MDA, a marker of lipid peroxides) were assessed spectrophotometrically. Mean Malonaldehyde level in PIH patients (8.48 ± 0.96) & Cervical patients (8.31 ± 1.25) in comparison to normal patients (4.88 ± 1.035), the rise was found highly significant (p < 0.001). The enzymatic activity of antioxidants such as Superoxide dismutase, Catalase, vitamin C and vitamin E was decreased in PIH patients & cervical dysplasia patients as compared to normal patients (p < 0.001). The difference was statistically significant (p < 0.001) whereas the same was observed in cervical dysplasia patients. No statistically difference was observed between the levels of antioxidants of PIH patients & cervical dysplasia patients (p < 0.01). Co-relation of Hb with MDA level showed that aneamic patients have raised level of MDA as compared to non aneamic patients. There is positive oxidant/antioxidant balance which may aggravate free radical damage during pre eclampsia and eclampsia with cervical dysplasia.
CSIR-Central Drug Research Institute, Lucknow is a premier R&D Institute under the aegis of the Council of Scientific and Industrial Research (CSIR), New Delhi which is an autonomous body under Department of Scientific and Industrial Research, Government of India.
The Babasaheb Bhimrao Ambedkar University, Lucknow is one of the youngest central universities in the country. The jurisdiction of this residential University is over the entire state of Uttar Pradesh. The campus Vidya Vihar is located off Rae Bareli Road, about 10 kms south of the Charbagh Railway Station, Lucknow.
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