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  • Harnessing big data helps scientists hone in on new antimicrobials

    Researchers have developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets, providing clues for discovering alternatives to traditional antibiotics.
  • Same workout, different weight loss: Signal molecule versions are key

    Some people lose weight slower than others after workouts, and a Kobe University research team found a reason. They studied what happens to mice that cannot produce signal molecules that respond specifically to short-term exercise and regulate the body’s energy metabolism. These mice consume less oxygen during workouts, burn less fat and are thus also more susceptible to gaining weight. Since the team found this connection also in humans, the newly gained knowledge of this mechanism might provide a pathway for treating obesity. 

  • Distinct T-cell signatures observed at different stages of type 1 diabetes development
    A study conducted at the University of Eastern Finland found distinct signatures in CD8-positive T cells in blood samples from children with newly diagnosed type 1 diabetes and in autoantibody-positive children who later developed type 1 diabetes. The study was published in the journal Diabetes.
  • Phage-Derived Enzyme Targets E. faecalis Biofilms to Mitigate Acute Graft-Versus-Host Disease

    Acute graft-versus-host disease (aGVHD) is a medical condition that occurs when donor immune cells attack the recipient's tissues after an allogeneic hematopoietic stem cell transplantation (allo-HCT). The pathogenesis of aGVHD is influenced by gut dysbiosis and Enterococcus domination. Researchers from Japan recently identified a bacteriophage-derived enzyme called endolysin capable of targeting biofilms formed by Enterococcus faecalis. Their findings offer hope for tailored interventions in allo-HCT.

  • Sleep timer for immune cells discovered
    In chronic hepatitis B, the liver contains immune cells that could destroy hepatitis B virus-infected cells but are inactive. A team from the Technical University of Munich has discovered that cells in blood vessels in the liver start a sleep timer that switches off immune cells. Targeting this mechanism could be a starting point for immunotherapies.
  • Johnson & Johnson receives approval from USFDA and European Commission for SIRTURO (bedaquiline)
    Johnson and Johnson announced that the US Food and Drug Administration has issued traditional approval for SIRTURO bedaquiline as part of combination therapy in adult and pediatric patients 5 years and older and weighing at least 15 kg with pulmonary tuberculosis due to Mycobacterium tuberculosis resistant to at least rifampicin and isoniazid
  • Nerve damage from cancer treatment can be predicted

    Many women treated for breast cancer using taxanes, a type of cytostatic drug, often experience side effects in the nervous system. Researchers at LiU have developed a tool that can predict the risk level for each individual. The tool could help doctors adapt treatment to avoid persistent side effects in those at the greatest risk. 

  • Drugs that kill zombie cells may benefit some older women, but not all, Mayo Clinic study finds
    Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a one-size-fits-all remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings published today in Nature Medicine.
  • Low-dose aspirin could help prevent pregnancy complications caused by flu infections
    A world-first study has found low-dose aspirin may treat flu-induced blood vessel inflammation, creating better blood flow to the placenta during pregnancy.
  • Industry Leaders Converge for 4th Computer Software Assurance 2024 : Enhancing Pharma Compliance and Innovation

    The 4th Computer Software Assurance 2024: CSx - Define your Variable and Assure your Validation, held by Eminence Business Media on June 20th-21st, 2024 at Radisson Blu Mumbai International Airport, was a resounding success. The event featured over 100 delegates, and industry leaders offering tailored solutions to streamline the CSV process for pharma companies. With dedicated Q&A rounds, presentations, and case study discussions throughout the day, the event proved to be both informative and interactive.

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