Chennai

10 December 2012

Archives of Jobs & Projects for B.Pharm, M.Pharm, B.Sc, M.Sc, MBBS, MD of Fresher or Experience of September 2012

September 2012
22 November 2012

FORMULATION AND EVALUATION OF CINITAPRIDE TABLETS AS FLOATING DRUG DELIVERY SYSTEM

About Authors:
S.Dinesh*, M.Senthil Kumar, Ashok kumar, Hariharan, jenish, Marshal joseph
Annai veilankanni’s pharmacy college
saidapet, chennai – 600 015.
Tamil nadu, pin:600015
*dinesh.pharmacy@gmail.com

ABSTRACT
Cinitapride1-2, chemically4-amino-N[3-(Cyclohexan-1-yl-methyl)-4-piperidinyl]-2-ethoxy-5-nitrobenzamide has the molecular formula C₂₁H₃₀N₄O₄ and molecular weight 402.49 g.Cinitapride is a drug that has against action to the serotoninergic 5-HT₂ and D₂ dopaminergic receptors that has been indicated in the gastro esophageal reflux and in the functional disorders of gastrointestinal motility treatment, The present study was aimed to formulate and evaluvate the tablets containing Cinitapride based on floating technique in order to increase gastric retention time, Total 9 formulation (F1-F9)were done using 3 different polymers like (HPMC k4m, HPMC e15m and HPMC k100m ). The formulations prepared were subjected to dissolution tests for 12 hrs, Among all the 9 formulation formulation (F5) were able to efficiently control Cinitapride release over a time period of 12 hrs. Thus the results of the current study clearly indicate, a promising potential of the floating tablet as an alternative to conventional dosage form.
21 November 2012

FORMULATION AND EVALUATION OF FLOATING TABLETS USING ALFUZOSIN HYDROCHLORIDE AS A MODEL DRUG

About Authors:
Jenish.R*, M.Senthil kumar, Dinesh, Ahokkumar, Marshel, Hariharan
Annai veilankanni’s college of pharmacy
Saidapet, Chennai-600015
Tamilnadu
*jenishnathan@gmail.com

ABSTRACT
Alfuzosin is a non-subtype specific alpha(1)-adrenergic blocking agent that exhibits selectivity for alpha(1)-adrenergic receptors in the lower urinary tract. Inhibition of these adrenoreceptors leads to the relaxation of smooth muscle in the bladder neck and prostate, resulting in the improvement in urine flow and a reduction in symptoms in benign prostate hyperplasia. Alfuzosin also inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. The alfuzosin of the present investigation is designed to retain in the stomach and deliver the drug alfuzosin for longer periods of time. The developed floating provides increased absorption of the alfuzosin at a rate such that effective plasma levels can be achieved and maintained for a prolonged duration. Formulations 6 displayed drug release considered in 0.1N HCL and Formulation 6 shows better drug release in dissolution profile.
11 November 2012

Area Sales Manager require in Synergy Diagnostics | All India Level

Synergy Diagnostics pvt Ltd, a Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.
11 November 2012

STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR CINACALCET HYDROCHLORIDE API

About Authors:
Gautam Kumar
SRM college of pharmacy, SRM University
Chennai 600 033.
gautamsinghsrmcp@gmail.com

Abstract
The aim of the present work to develop validated RP-HPLC method which determines stress stability and concentration of Cinacalcet hydrochloride in synthetic mixture as per ICH guidelines. Separation was performed using Camag Linomat V semi Automated sample applicator with TLC Scanner III. Stationary Phase consisting of TLC plates (Merck) pre coated with silica gel 60F₂₅₄ on Aluminum Sheets was used. Mobile phase comprising of Methanol: Water: Glacial acetic acid (5:5:0.2v/v/v) was used. All the system suitability parameter was found within the range. The method was extensively validated for specificity, linearity, accuracy, precision, recovery, limit of quantitation and detection. The Cinacalcet hydrochloride was found to be highly labile to alkaline and acid hydrolysis compared to oxidation. Chromatographic peak purity results indicated the absence of co-eluting peaks with the main peak of Cinacalcet, which demonstrated the specificity of assay method for estimation of Cinacalcet in presence of degradation products. The proposed method can be used for routine analysis of Cinacalcet in quality control laboratories.
8 November 2012

HBL invites Deputy Manager - Formulation, Production, QA, QC, Regulatory Affairs, Animal House

HLL Biotech Limited (HBL) is a 100% subsidiary of HLL Lifecare Limited, a Mini Ratna Schedule B Central Public Sector Enterprise under the Ministry of Health & Family Welfare. HBL is setting up a vaccine complex at Chengalpett, Chennai for manufacturing of Bacterial and Viral Vaccines & developing a strong R&D base for vaccine technologies within the country.
8 November 2012

Work as Area sales Executive/Medical representative in Synergy Diagnostics - Freshers may apply

Synergy Diagnostics pvt Ltd, a Leading Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.
5 November 2012

PREPARATION OF VILOXAZINE SUSTAINED RELEASE DRUG DELIVERY SYSTEM BY USING ETHYLCELLULOSE, CARBOPOL, SODIUM ALGINATE, HYDROXY PROPYL METHYL CELLULOSE & GUAR GUM

About Authors:
D. HariHaran*, M. Senthil kumar, M. Ashok Kumar, S. Dinesh & R.Jenish.
Annai Veilankanni’s College of Pharmacy,
81, V.G.P. Salai, Saidapet, Chennai-600015.
*haran_pharma@yahoo.com

ABSTRACT
The present study behind this work is to find to prepare sustained release tablets of Viloxazine by compression method. First of all to formulate Viloxazine sustained release tablets using the Ethylcellulose, Carbopol, Sodium Alginate, Hydroxy propyl methyl cellulose & Guar gum under ratio’s like 1:1, 1:1, 1:1,1:1,1:1 . Five batches were made in various polymers of ethylcellulose, carbopol, sodium alginate,hydroxy propyl methyl cellulose & guar gum is used by keeping the drug as constant. Then evaluation of Viloxazine sustained release tablets was carried out for characteristics like drug content in tablet, UV analysis. In vitro release starts from 1hr and up to 24hrs. It shows the percentage of gradual drug release as 17.80%, 27.65%, 35.12%, 45.16%, 51.20%, 57.42%, 61.30%, 66.32%, 72.08%, 77.15%, 81.32%, 84.48% & 98.20% against the label claim as 40mg.
30 October 2012

“Professional Certificate in Pharmacovigilance” program by Catalyst Clinical Services | Special Discount of 10% for Pharmatutor Visitors

Pharmacovigilance is the pharmacological sciences relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term side effects of the therapeutic drugs, devices and biologics. Setting up of stringent laws by regulatory bodies (e.g.
29 October 2012

DEVELOPMENT AND VALIDATION OF QUETIAPINE BY HPTLC METHOD

About Author:
Gautam Kumar
SRM college of pharmacy,SRM University
Chennai 600 033.
gautamsinghsrmcp@gmail.com

Abstract
The aim of the present work is to develop validated HPTLC method which determines stress stability and concentration of Quetiapine and its formulation as per ICH guidelines. Separation was performed using Camag Linomat V semi Automated sample applicator with TLC Scanner III. HPTLC analytical measurement and separation were performed using Stationary Phase consisting of TLC plates (Merck) pre coated with silica gel 60F254 on Aluminum Sheets was used. Mobile phase comprising of Methanol: Toluene (7:3 v/v) was used. All the system suitability parameter was found within the range. Area under curve was measured at 235nm. The method was extensively validated for specificity, linearity, accuracy, precision, recovery, limit of quantitation and detection. The proposed method can be used for routine analysis of Quetiapine in quality control laboratories.