About Authors:
Ashokkumar.m*, M.Senthil kumar, Dinesh, Jenish, Marshel, Hariharan
Annai veilankanni’s college of pharmacy
Saidapet, Chennai-600015, Tamilnadu
*mgashokkumar123@gmail.com
ABSTRACT
Atypical antipsychotic Quetiapine was used for the treatment of schizophrenia is a severe illness with substantial effects on individual and social functioning, Quetiapine and its active metabolite N-desalkyl-Quetiapine have affinities to dopaminergic D1-and D2receptors,5-HT2 receptors. To design of immediate release dosage form of quetiapine fumarate that will help in releasing drug with short period of time. The quetiapine fumarate tablets were successfully prepared by direct compression method. The physiochemical evaluation results for the powdered material of all trials pass the official limits in angle of repose, compressibility index and drug content. In the 9 trials, the optimized formulation was F3 trial which releases the quetiapine fumarate immediately within an hour.