Meyer,an associate of London based multinational Vitabiotics Ltd.,is a rapidly growing Pharma Co. in India. Leading pharmaceutical manufacturer, founded in 1982 .,in technical collaboration with OMEGA-MEYER Ltd Jersey( Br. Isles). H.O. based in THANE

Post: PMT- Trainee

About Authors: Seema Meena, Anil Kumar and Shikha Chauhan
a) Amity Institute of Pharmacy, Amity University, Noida,-201301, India.
b) Neuropharmacology division, University Institute of Pharmaceutical Sciences, UGC Centre for Advance Studies, Panjab University, chandigarh-160014, India.

Abstract:
Neuropathic pain represents a real clinical challenge because of its severity, chronic nature, and inadequate drug therapy. Recently, nitric oxide pathway has been proposed in the pathogenesis neuropathic pain like conditions. Curcumin is a well known for its antioxidant and medicinal values. The objective of the present study was to explore possible nitric oxide mechanism in the protective effect of curcumin against sciatic nerve ligation induced behavioral and biochemical alterations in rats.Sciatic nerve ligation was performed in Wistar rats. Various behavioral parameters (thermal hyperalgesia, cold allodynia) followed by assessment of biochemical parameters (lipid peroxidation, reduced glutathione, catalase, and nitrite) both on sciatic nerves and brain. Sciatic nerve ligation significantly caused thermal hyeralgesia, cold allodynia and oxidative damage as compared to sham (Sciatic nerve without ligation) and naïve animals. Chronic administration of curcumin (20 mg/kg, po) significantly reversed behavioral alteration and attenuated oxidative damage in both sciatic nerve and brain as compared to control.  Further, L-NAME (5 mg/kg) pretreatment with curcumin (10 mg/kg, po) potentiated protective effect of curcumin as compared to their effect per se. However, L-arginine (100 mg/kg) pretreatment with curcumin (10 mg/kg, po) significantly reversed the protective effects of curcumin. Result of present study suggests that nitric oxide mechanism could be involved in the protective effect of curcumin against sciatic nerve ligation induced behavior and biochemical alterations in rats.

About Author: Sayani Chakrabarti
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia
Mayurbhanj-757086
Orissa

ABSTRACT
Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It has potential anti oxidant effect. A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy. BAP I). The study period was 8 weeks and 84 patients fulfilled all the prerequisite criteria and completed the study as planned. Benfotiamine led to significant improvement of alcoholic polyneuropathy. Vibration perception (measured at the tip of the great toe) significantly improved in the course of the study, as did motor function, and the overall score reflecting the entire range of symptoms of alcoholic polyneuropathy. A tendency toward improvement was evident for pain and co-ordination, no therapy-specific adverse effects were seen.

Rajat Pharmachem Ltd. is a Formulation plant located at Ankleshwar, Bharuch - Dist, Gujarat. The company is engaged in the manufacturing of formulation like Tablets, Capsules, Oral Powder & Effervescent Tablet.
The the company is WHO-GMP, NAFDAC - Nigeria, FDB Ghana, ISO 9001:2008, ISO 22000:2005 approved company.
The company is having vast range of tablets, capsules, powder and lataste technology of effervescent tablet manufacturing.

Thomson Reuters is the leading source of intelligent information for the world's businesses and professionals, providing customers with competitive advantage.

The Scienomics Group (TSG) is a full-service communications company based in Greenwich, CT, with offices in New York and San Francisco that provides medical education services globally to support pharmaceutical products and devices/diagnostics throughout a product’s lifecycle. Services offered by TSG include scientific message development, gap analyses, strategic planning, publications and program planning and implementation, live events, speakers’ bureau, and much more.

Wallace Pharmaceuticals is a progressive, professionally managed and growing pharmaceutical company with a special focus on Antibiotic, Anti -infective, Analgesic, Anti-inflammatory, Antiacne, Paediatric, Orthopaedic, Dermatology and Diabetic segments.

Post: Medical Representative

Zydus Cadila is a fully integrated, global healthcare provider, with strengths all along the pharmaceutical value chain. With a core competence in the field of healthcare, Zydus Cadila provides total healthcare solutions ranging from formulations, active pharmaceutical ingredients (API) and animal healthcare products to wellness products.

Guardian Pharmacy is a six-year-old retail chain of Pharmacy, Wellness, Health and Beauty Stores. Based on the premise of service and reliability the company currently serves 7.5 million customers annually and is India’s fastest growing pharmacy retail chain with more than 200 outlets.

Nectar Lifesciences Ltd., Chandigarh, India a US$ 200 million company engaged in the business of manufacturing & marketing products in lifesciences particularly Antibacterial I.e. Cephalosporins with 40% market share in API's I.e. 3rd & 4th generation Cephalosporins out of India.

Medusind Solutions®, one of the leading outsourcing companies, provides integrated healthcare business solutions, both on and offshore. We take pride in utilizing global resources to cover physician practices, hospitals, dental groups, and third party billing companies.

The State of Kerala was formed on 1st November 1956 consequent on the Reorganisation of States. It comprises the former Travancore-Cochin State (except the present Kanyakumari District and Shencottah Taluk of the present Tamil Nadu) and the Malabar District and the Kasargod Taluk of South Kanara District of the then composite Madras State.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output. This university has two campuses, 3 institutes, 16 faculties, 140 departments, 4 advanced centers and 4 interdisciplinary schools.

J. B. Chemicals & Pharmaceuticals Ltd. (JBCPL), known to many as Unique Pharmaceutical Laboratories is one of India's leading global pharmaceutical companies. The company manufactures and markets a wide range of pharmaceutical formulations.

Post:  Head/Vice President/General Manager-QA/QC

Famy care is a global player in the Female Health Care Segment with a focus on Hormonal & Reproductive Health Care Products. Famy care believes in the right of women to be informed about their reproductive healthcare choices and to make good health accessible to all. In a very short span of time we have become the largest manufacturer of Hormonal Tablets.

Originally Gujarat based Company presence of 35 years in Pharma formulation having own marketing setup as well as 3rd party/loan licence activity at Gujarat and Dehradun plant.

United Biotech has been a trend setter of new standards and is among the fastest growing companies in the Indian pharmaceutical Industry. In a span of 12 years it has established an enviable reputation and track record for adopting latest manufacturing technologies, introducing world-class quality of products, ground breaking Research & Development efforts in association with its foreign counterparts and for setting new standards of customer service.

Symbiotec Pharmalab Ltd., a cortico-steroids API manufacturing company based at Indore in Central India is in the business of development, production and marketing of research-based cortico steroids.