November 2012

8 November 2012

OXAZOLE – ISOXAZOLE: MOLECULE OF DIVERSE BIOLOGICAL ACTIVITIES

About Authors:
*C.P.Meher, S.P.Sethy, S. M Ahmed
Department of pharmaceutical Chemistry, Maheshwara college of Pharmacy,
chitkul (V), Isnapur “X” Road, patancheru, Hyderabad.
*chaitanyameher84@gmail.com

ABSTRACT:-
Heterocyclic chemistry is vastly expanding because of the enormous amount of research work being done in this area. Heterocyclic compound are very widely distributed in nature and are particularly important because of the wide variety of physiological activities associated with this class of substances . A great deal of research is carried out to prepare new heterocyclic molecules having therapeutic uses.[1] and also so many heterocyclic derivative are synthesized till now having desired pharmacological effect. Out of them oxazole & isoxazole derivatives are catagorised in a higher position as the other heterocyclic compound possess in the hetero-chemistry. The present review is concern with the comparative study of the derivative of oxazole & isoxazole derivatives along with their pharmacological effects.

8 November 2012

BOTULINUM TOXIN TYPE A TREATMENT FOR COSMETIC AND MEDICINAL USE

About Authors:
*Lavkesh A.Chandivade, Vishal V.Bandre, Nilesh M. Choudhary
Viva Institute of Pharmacy
Shirgaon ,Virar(E)
*lavkeshc@gmail.com

ABSTRACT:
BOTULINUM TOXIN is a neurotoxin that is made of a complex mixture of proteins containing botulinum neurotoxin and various non-toxic proteins.
The neurotoxin clostridium botulinum is a spore-forming gram positive anaerobic bacterium that is made up of light chain and a heavy chain linked by single disulphide bond. The non-toxic proteins include haemagglutinating proteins. The bacteria are considered harmful and life threatening and can lead to muscle paralysis or weakness. However Botulin toxin treatment is quite safe especially when used in small doses and injected directly to a specific area.

7 November 2012

Multiple vacancies in HLL Lifecare | Require Asst manager in Animal House, Formulation, Production, Quality Assurance, Quality Control, Regulatory Affairs department - Mini Ratna Company of Govt. of India

HLL Lifecare Limited is a Mini Ratna Company of Govt. of India under the Ministry of Health & Family Welfare. HLL, a schedule B Public Sector Enterprise, is today a multi product, multi location organization addressing various public health challenges. The company with six manufacturing units and marketing offices throughout the country is engaged in the manufacturing and marketing of a wide range of contraceptives and healthcare products.

7 November 2012

Work Senior Project Fellow (Pharma) in HLLs Corporate Research and Development Centre

HLL's Corporate Research and Development Centre (CDRC) is a centre of excellence with world class laboratories implementing R&D projects both in-house and as well as on collaborative mode with other premier academic and research institutions in the country and abroad including Indian Institute of Technology Kanpur (IITK), Indian Council of Medical Research New Delhi (ICMR) , Central Drug Research Institute, etc.

7 November 2012

Job as Senior Research Fellow in ACTREC | Walk in

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India.

7 November 2012

Opportunity for Logisitcs/SCM Executive, females (PHARMA) in Leading pharma company located in Mumbai- Aspiring Solutions

Aspiring-Solutions is a passion driven and one stop over HR consulting services based in Mumbai. We undertake bulk operations and specialize in undertaking all level recruitments inorder to cater the needs of different companies. Our motto is to provide quality candidates so as to meet the set expectations of our clients.

7 November 2012

APPLICATION OF LC-MS

About Authors:
Jatin Patel^1*, Prof. Rajesh Kumar Dholpuria², Dhiren Shah¹
²(Professor, Head of Department of pharmacognosy),
¹Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
*Patelj313@yahoo.com

ABSTRACT:
Liquid chromatography is a fundamental separation technique in the life sciences and related fields of chemistry. Unlike gas chromatography, which is unsuitable for nonvolatile and thermally fragile molecules, liquid chromatography can safely separate a very wide range of organic compounds, from small-molecule drug metabolites to peptides and proteins. Traditional detectors for liquid chromatography include refractive index, electrochemical, fluorescence, and ultraviolet-visible (UV-Vis) detectors. Some of these generate two- dimensional data; that is, data representing signal strength as a function of time. Others, including fluorescence and diode- array UV-Vis detectors, generate three-dimensional data. Three-dimensional data include not only signal strength but spectral data for each point in time. Mass spectrometers also generate three- dimensional data. In addition to signal strength, they generate mass spectral data that can provide valuable information about the molecular weight, structure, identity, quantity, and purity of a sample. Mass spectral data add specificity that increases confidence in the results of both qualitative and quantitative analyses. For most compounds, a mass spectrometer is more sensitive and far more specific than all other LC detectors. It can analyze compounds that lack a suitable chromophore. It can also identify components in unresolved chromatographic peaks, reducing the need for perfect chromatography. Mass spectral data complements data from other LC detectors. While two compounds may have similar UV spectra or similar mass spectra, it is uncommon for them to have both. The two orthogonal sets of data can be used to confidently identify, confirm, and quantify compounds.

6 November 2012

Opportunity for PHAD HEAD in Novartis

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

6 November 2012

Work as Quality Assurance in Icon Clinical Research

ICON is a global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries. We specialize in the strategic development, management and analysis of programs that support Clinical Development – from compound selection to Phase I - IV clinical studies

6 November 2012

ROLE OF HULK PROTEIN- “GRB 10” IN ENHANCEMENT OF MUSCLE MASS: A CLINICAL REVIEW

About Authors:
Mr. Satyanand Tyagi*, Patel Chirag J¹, Devesh Kaushik²
*President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic work includes 60 Publications (50 Review Articles, 08 Research Articles and 02 Short Communications of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 60 publications, 11 are International Publications).
He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders, psycho-pharmacological agents as well as epilepsy.
¹Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*sntyagi9@yahoo.com, +91-9871111375/9582025220

ABSTRACT:
A group of Australian researchers at the Garvan Institute in Sydney have conducted a study indicating how Grb10 protein plays a crucial role in increasing muscle mass during development. Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Over expression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.Scientists have discovered a way to build bigger and stronger muscles without having to lift a finger.