September 2012

21 September 2012

Application are invited from MBBS/BDS/BAMS/BHMS/M.Pharm/M.Tech for post of Senior Research Fellow in UCMS

The University College of Medical Sciences (UCMS) was established in 1971 as a Constituent College of University of Delhi. It imparts various medical and paramedical courses. Guru Teg Bahadur Hospital is the associated teaching hospital with 1000 beds.

21 September 2012

Multiple vacancies in Comed : Require Sr Manager/ Manager, Business Development Manager, Manager / Asst Manager

Comed was in 1986, when a team of experienced and energetic Pharma professionals decided to go big and to do something different and better than routine. A seed was sown: a beginning was made. These young, dynamic and experienced future leaders chose Baroda (Now called Vadodara), the Educational and Pharma capital of Gujarat (Western India) as their base, a choice which itself proved to be big contributing factor for growth.

21 September 2012

Multiple vacancies in Quality Assurance, Production at Panacea Biotec

Panacea Biotec is a leading research based Health Management Company, with an annual turnover of approx. Rs. 830 Crores. We are engaged in research, development, manufacture & marketing of Vaccines, Bio-Pharmaceuticals and Pharmaceuticals (Rx & OTC) of international quality and Health Services.

21 September 2012

BIOSENSOR - Micro electrochemical device

About Authors:
Vedant M. Pandya
Department of biotechnology, shree M & N Virani science college,
Rajkot, India-360005
vedantpandya007@gmail.com

ABSTRACT
A biosensor is a device for the detection of an analyte that combines a biological component with physicochemical detector components. An integrated device consisting of a biological recognition element & a transducer capable of detecting the biological reaction & converting it into a signal which can be processed. Ideally, the sensor shod be self-contained, so that it is not necessary to add reagents to the sample matrix to obtain the desired response. There are a number of analytes which are measured in biological media: pH, partial pressure of carbon dioxide, partial pressure of oxygen & the ionic concentration of sodium, potassium, calcium & chloride. Biosensors are typically classified by the type of recognition element or transduction element employed. Sensors might be described as a catalytic biosensor if it is recognition element comprised an enzyme or series of enzymes, a living tissue slice, or whole cells derived from microorganisms such as bacteria, fungi, or yeast. The sensor might be described as a bioaffinity sensor if the basis of operation were a biospecific complex formation. Accordingly, the reaction of an antibody with an antigen or hapten, or the reaction of an ageist or antagonist with a receptor, could be employed. In the former case, the sensor might be called an immunosensor. Since, enzyme-based sensor measure the rate of the enzyme-catalyzed reaction as the basis for their response, any physical measurement which yield a quantity related to this rate can be used for detection. The enzyme may be immobilized on the end of an optical fiber, & the spectroscopic properties related to the disappearance of the reactants or appearance of products of the reaction can be measured. Since biochemical reaction can be either endothermic or exothermic. Miniaturized thermistor based calorimeter called thermistos, have been developed & widely applied, especially for bioprocess monitoring.

21 September 2012

DENDRIMER : FOR NOVEL DRUG DELIVERY SYSTEM- A REVIEW ARTICLE

About Author:
Deepa yadav
M.Pharm
Rameshwaram institute of Technology and management, Lucknow
deepa.yadav.amethi@gmail.com

ABSTRACT:
Dendrimers have emerged as one of the most interesting themes for researchers as a result of unique functional architecture and macromolecular characteristics dendrimer, have attracted great attention in terms of biomedical applications. Although the PAMAMdendrimer has already been tested as a carrier for drugs and genes and as a contrast agent for bioimaging . This mini review highlights issues associated with the use of dendrimers as drug delivery vehicles. This article provides an insight into the structure, synthesis, properties,types and the applications of dendrimers in the bio-medical field.

20 September 2012

RAJIV GANDHI UNIVERSITY OF KNOWLEDGE TECHNOLOGIES invites Pharmasists- 6 Posts

The Government of Andhra Pradesh has established Rajiv Gandhi University of Knowledge Technologies (RGUKT) in 2008 to cater to the educational needs of the meritorious rural youth of Andhra Pradesh. Three campuses of RGUKT (fully residential) were started under the University, one each at Basar (Adilabad Dt), Nuzvid (Krishna Dt), Rajiv Knowledge Valley, Idupulapaya (YSR Kadapa Dt).

20 September 2012

Walk in interview for B.Pharm/B.Sc as Project Assistant @ Advanced Centre for Treatment, Research and Education in Cancer

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer

20 September 2012

Work as Therapy Lead in Pfizer India

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals.

20 September 2012

CHRONOPHARMACOKINETICS: THE CIRCADIAN RHYTHM OF DRUGS AND ITS IMPLICATIONS

About Authors:
N Allamneni*, CH Ajay Babu, AVS Madhulatha, C Anusha, P Sowjanya, BV Komali, M Kalyani, Syed M
*Department of Pharmaceutical Technology,
Narasaraopeta Institute of Pharmaceutical Sciences,
Narasaraopeta, Guntur, India.
*yaswanthallamneni@gmail.com

ABSTRACT
Chronopharmacokinetics involves the study of temporal changes in drug absorption, distribution, metabolism and excretion with respect to time of administration. Drug Absorption, distribution, metabolism and elimination are influenced by many different physiological functions of the body, which may vary, with time of day. Thus, the pharmacokinetic parameters characterizing these different steps, conventionally considered to be constant in time, depend on the moment of drug administration. Chronokinetic studies have been reported for many drugs in an attempt to explain chronopharmacodynamic phenomena and demonstrate that the time of administration is a possible factor of variation in the kinetics of a drug. However, the time of day has to be regarded as an additional variable influencing the kinetics of a drug since many drugs are affected by time of administration and the activity or rest period of the human or animal.

20 September 2012

STRUCTURE BASED DRUG DESIGN OF PIPERAZINE LINKED HYDROXAMIC ACID DERIVATIVES AS HDAC INHIBITOR

About Authors:
Avisek Mukhopadhyay*, Subhasis Banerjee
Gupta College Of Technological Sciences
M.Pharm(Bit Mesra, Ranchi)
*avisekmukhopadhyay7@gmail.com

INTRODUCTION
Urbanization, industrialization, changes in lifestyles, population growth and ageing all have contributed for epidemiological transition in the country. The absolute number of new cancer cases is increasing rapidly, due to growth in size of the population, and increase in the proportion of elderly persons as a result of improved life expectancy following control of communicable diseases. In India, the life expectancy at birth has steadily risen from 45 years in 1971 to 62 years in 1991, indicating a shift in demographic profile. It is estimated that life expectancy of Indian population will increase to 70 years by 2021–25. Such changes in the age structure would automatically alter the disease pattern associated with ageing and increase the burden of problems such as cancer, cardiovascular and other non-communicable diseases in the society.The latest global figures show that in 2004, there were 11.4 million cases of cancer diagnosed worldwide, and 75% of these were in Europe, the Americas and the Western Pacific Region. The Western Pacific Region includes China, Malaysia, Japan, Australia and New Zealand. The lowest numbers of cases were diagnosed in the Eastern Mediterranean region (includes Saudi Arabia, Egypt Iraq, Morocco, Tunisia) and Africa.
There were differences in the top three most common cancers in each region. The top three included lung cancer in all regions except Africa and included breast cancer in all except for the Western Pacific region. Cervical cancer was in the top three in Africa and South-East Asia only and bowel cancer in the top three for Europe only. Prostate cancer was in the top three in Africa and the Americas.Let us discuss one of the most promising targets of these days, which when overexpressed may cause cancer, i.e.;HISTONE DEACETYLASE.