About Authors:
H. S. Sawwalakhe*, J. M. Maidankar, M. A. Channawar, Dr. A. V. Chandewar
P. W. College of Pharmacy, Yavatmal,
Amravati university
*hemant_11sep@rediffmail.com
ABSTRACT:
Occular drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientists, the major problem encountered to pharmaceutical scientist is rapid precorneal elimination of the drug, resulting in poor bioavailability and therapeutic response, because of high tear fluid turnover and dynamics. In situ-forming gels are liquid upon instillation and undergo phase transition in the ocular cul de-sac to form visco-elastic gel and these gels provides a response to environmental changes. In the past few years, an impressive number of novel temperature, pH, and ion induced in situ-forming systems have been reported for sustained ophthalmic drug delivery. Each system has its own advantages and drawbacks. The choice of a particular gel depends on its intrinsic properties and envisaged therapeutic use. This review includes various temperature, pH, and ion induced in situ-forming polymeric systems used to achieve prolonged contact time of drugs with the cornea and increase their bioavailability Now a days in situ gel have been used as vehicles for the delivery of drugs for both local treatment and systemic effects. Different administration routes other than ocular have been explored, and these cutaneous and subcutaneous delivery, dental, buccal delivery and delivery to the esophagus, stomach, colon, rectum and vagina.