January 2012

The National Brain Research Centre (NBRC) was established by the Department of Biotechnology, Ministry of Science & Technolgy, Government of India, in November 1997 as a fully funded autonomous research institute in the area of neuroscience and brain. The Centre was registered as an Society in June 1999 under the Registration of Societies Act.

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai.

Neon was on preparation for Indian Market that the company first concentrated. However, it was only a few years later we began manufacturing to order medicines for Pharmaceutical company. Finally, in 1985 NEON entered into ethical marketing having wide set up of marketing team.
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About Authors:
Kalpesh N. Patel¹*, Jayvadan K. Patel^2
1 Research Scholar, Jodhpur National University, Jodhpur,
Rajshathan, India
² Department of Pharmaceutical Technology,
Nootan Pharmacy College,
Visnagar (GUJARAT), India.

Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of pyrimethamine and sulphadoxine from tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 215 nm (λmax of pyrimethamine) and 254 nm (λmax of sulphadoxine) in methanol and Method-II first order derivative spectroscopic method involves the measurement of absorbances at two wavelengths 250 nm (λmax of pyrimethamine) and 220.5 nm (λmax of sulphadoxine); The linearity lies between 5-30 µg/ml for both pyrimethamine and sulphadoxine for all the two methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of pyrimethamine and sulphadoxine in bulk and combined dosage form.

The Company (Manufacturing Ayurvedic and Unani Medicines) having obtained drug licence from licensing authority (G.M.P.