September 2011

About Author: Mr. Naresh. M. Reddy
PG Diploma (Cheminformatics),
Nizam College, Osmania University
Hyderabad.

Abstract
Oral strontium ranelate is an alternative oral treatment, belonging to a class of drugs called dual action bone agents. The objective of this investigation was to characterize and determine the effect of the Strontium ranelate on Calcium sensor receptor (CASR) which is an important protein involved Osteophoresis. Homology modeling of CASR has been performed based on the crystal structure of the 2E4U (Chain A) by using Modeller software. With the aid of the molecular mechanics and molecular dynamics methods, the final model is obtained and is further assessed by procheck and verify 3D graph programs, which showed that the final refined model is reliable. With this model, a flexible docking study of CASR with a group of Ranelic acids were selected from the previous publications was performed. The results indicated that VAL1,SER18,SER2,GLU241 in CASR are important determinant residues in binding as they have strong hydrogen bonding with Ranelic acids. These hydrogen binding interactions play an important role for stability of the complex. Among the 15 compunds, 6th showed best docking result. Our results may be helpful for further experimental investigations.

They do not find any direct references of Sangli before 1801. Historical references since 1024 show areas called Mirinch i.e presently Miraj and Karhatak  i.e. Karad under the areas rules by Gonk  a Shilahar  king and sangli was included in these areas. The first clear and direct refernce to sangli can be found in the sankrit poem Shiv-Bharat. During the time of Shivaji Maharaj, his courageous Sarnoubat  Netaji Palkar captured Sangli, Miraj and Brahmnal from the Adilshah in 1659.

Zydus Cadila is a professionally managed public company offering immense opportunities to learn and grow. This ability to evolve, gain new capabilities and raise the bar of excellence forms the heart of our success. We provide an environment where people come and give their best not because they have to, but because they want to. At Zydus we build people to build our business.

Indian Institute of Chemical Technology, Hyderabad is a premier R&D Institute in India. The Institute had its origin as the Central Laboratories for Scientific & Industrial Research (CLSIR), established in 1944 by the then Government of Hyderabad State. After integration of Hyderabad State with the Indian Union, the laboratory expanded with its growing activities. The main building was formally opened by Pandit Jawaharlal Nehru, the then Prime Minister of India on January 2, 1954.

They at Isshaan are committed to their customers and employees and, more importantly, to the people who rely on their medicines. They are committed to march ahead with a clearer vision and greater vitality, working towards what really matters – health.