April 2011

About Author
Sayani Chakrabarati,
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia
Mayurbhanj-757086
Orissa

Introduction
In pharmaceutical industries, many unprecedented challenges have to be faced regarding cost, time, labour, tough competition by other companies etc. To overcome these problems & curve a significant niche in global market, a new approach has been brought named lean sigma. This concept is used to make work BETTER & FASTER. Many companies have embarked on major improvement programs, including internal re-organization, greater externalization to embrace the biotech culture & capture innovation, & the movement of investments to lower cost countries. The Lean Sigma is a very positive approach in such third-world countries like India. This approach will help to beat the recession after effects very soon with appreciable efficiency.

About Authors: NEHA BATRA, S K Dubey
M.PHARMACY-PHARMACOGNOSY
JNU-JAIPUR

ABSTRACT:
Ageing or aging is the accumulation of changes in an organism or object over time. Ageing in humans refers to a multidimensional process of physical, psychological, and social changes, the things you do this year can halt and even reverse many of health and cognitive issues faced by those over age 50. You could be in better shape, have fewer aches and pains AND have more energy than you did 10 years ago. Anti aging is possible. The body requires two vital materials- energy and raw material for anti-aging. There are many food and herbal treatment available in market for anti aging.

About Authors: HONEY JAIN, Mr Ranjan Bairwa
M.PHARM , PHARMACOGNOSY
JNU
JAIPUR

ABSTRACT
Even with improvements in health care, many Boomers are finding themselves overwhelmed with the stresses of modern life. Luckily, there are natural ways to relieve stress, including daily exercise, meditation, deep-breathing techniques and the use of time-honored herbal supplements.‘Stress response’ are many and varied-marriage, divorce, death of a loved one, new job, move, etc.-any intense emotion such as fear or anger, fatigue, physical injury, surgery, temperature extremes, noise, crowding, illness.
There is a definite relationship between stress and illness, although the exact nature of this relationship is not yet fully understood. The more frequent and severe the life changes, the more likely we are to become ill.Combination of key traditional anti-stress herbs may help settle down your world and step up your energy levels to dynamic new heights.

About Authors: Akram Ahmad⁽¹⁾*,Vikas Kumar⁽¹⁾ ,G.P.Mohanta⁽²⁾ and Hasna Ali⁽²⁾.
1-Christian school of pharmacy, FHMSIAMS (SHIATS) Allahabad (UP)-211007.
2-Department of pharmacy practice,Annamalai University,Chidambaram (T.N)-608002.

Abstract:
Antioxidants are helpful in increasing the blood circulation and thus help in hair growth as well as in the treatment a lot of diseases. Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. The Antioxidant property of plant and oil can be  utilise in hair fall .The objective of present study involves preparation of herbal hair oil using amla, brahmi, tridex, neem, shikakai and its evaluation for increase in hair growth activity. The oils with two different drug concentrations 5% & 10% were prepared using direct boiling, paste and cloth method. For determination of antioxidant activity DPPH method is used. Herbal hair oil formulation showing moderate antioxidant activity when compared with standard.it can be used as herbal hair oil for hair growth and other Free radical damage within cells has been linked to a range of disorders including cancer, arthritis, atherosclerosis, Alzheimer's disease, and diabetes.

About Authors: V.P. Patel^*, M.C. Gohel, R.K. Parikh
*V. P. Patel
M.Pharm, Assistant Professor, R. K. College of Pharmacy, Rajkot, Gujarat, India.
Work was carried out at: Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
M. C. Gohel
Professor and Principal, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
R. K. Parikh
Professor, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India

Abstract:
With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Other physiochemical and biopharmaceutical properties such as permeability, biopharmaceutics and metabolism are rarely considered during the selection process. The aim of this study was to increase dissolution rate of felodipine poorly soluble drugs from BCS class II by complexation process. Complexation was prepared using β cyclodextrine. Different techniques were employed for preparation of complexation with β cyclodextrin like physical mixture, cogrinding, kneading technology, solvent coevaporation.The physical properties of the prepared solid mass of felodipine was characterized by in vitro dissolution studies, UV- spectroscopy, Fourior transform infrared spectroscopy, differential scanning calorimetry (DSC) and  X-ray powder differaction spectroscopy. Additionaly, phase solubility studies were performed to support the in vitro dissolution study. The results of Fourior transform infrared spectroscopy shows the compatibility of drug with cyclodextrin, while differential scanning calorimetry (DSC) and X-ray powder differaction spectroscopy showed the confirmation of complexation of β cyclodextrin with felodipine.

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February 2011