Gujarat

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ABOUT AUTHORS:
Raval Aniket*, Chauhan Sachin P., Sheth A.K, Shah Nirmal, Aundhia Chintan
Department of Pharmacy, Sumandeep Vidyapeeth University,
At & Po Pipariya, Ta. - Waghodia, Dist. Vadodara, Gujarat, India
aniket_raval2006@yahoo.co.in

ABSTRACT:
The aim of present investigation is to formulate evaluate and optimization of colon targeted pellets bearing mebendazole, benzimidazole derivative with broad spectrum of anthelminthic activity. It is highly effective against adult and larval stages of ascaris lumbricoids, hook worms and  indicated for the treatment of nematode infestation. Pellets were prepared by extrusion spheronization process using microcrystalline cellulose as spheronizing aid, natural polysaccharide pectin as binders in three different percentages i.e 5%, 10% and 15% and glycerine as plasticizer.  Further study was carried out to select the natural polysaccharide for formulation of colon targeted pellets i.e. Pectine, Xanthan gum and Guar gum. The formulation were prepared with optimized constant process parameters i.e. Percentage LOD 10%, Spheronization time 3 minutes and Speed of spheronization 700-1200 rpm. Prepared A1 – A9 batches were then evaluated by their micromeritic properties like tapped density, carr’s index, hausner, S ratio, angle of repose  and characterized by microscopic study, % yield, hardness, friability, % assay and dissolution study was carried out and compared with marketed formulation by statistical analysis similarity factor (f₂). The batch A5 is having 10% pectin, 18% MCC and 20% mebendazole shows (22.20±2.05) % carr’s index, (1.22±0.04) hausner’s ratio, (26.65±1.15) angle of repose, (88.2±2.36) % yield, (3.96±0.46) hardness, (0.23±0.03) % friability  (88.47±3.26) % assay and (99.81±3.80) % drug release after 10 hours. Pellets equivalent to 300mg of mebendazole  were then filled in capsules and capsules coated with 12.5% w/v Eudragit S 100 using optimized 4- 5 ml/min spray rate, 15 rpm pan speed and 40±5°C coating inlet temperature and then optimized for % weight gain in four different trials. W2 batch having 10% weight gain were then evaluated by % cumulative drug release, disintegration test in 0.1 N HCl shows (99.73±3.34) % CDR, intact after 12 hours. The pellets of batch A5 and the enteric coated capsule with 10 % weight gain were packed in aluminum pouch and charged for accelerated stability studies at (40°C±2°C) and (75%±5%) RH for 1 month in a stability chamber shows no change in the dissolution profile at (40°C±2°C) and (75%±5%) RH storage condition.

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ABOUT AUTHORS:
Asif I Bhim*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat, India
bhimiqbal23@gmail.com

ABSTRACT:
Itopride Hydrochloride is a novel, synthesized, gastro prokinetic drug, which stimulates gastrointestinal motor activity through the synergistic effects of dopamine D2-receptor blockade and acetylcholine esterase inhibitors. Chemically, it is N-[[4-[2-(Dimethyl amino) ethoxy] phenyl] methyl]-3, 4-dimethoxy benzamide hydrochloride. Benzamide structure, amide and ether linkages in the drug molecule make it susceptible to degradation. Thus a prokinetic drug like Itopride Hydrochloride by virtue of its efficacy and tolerability could be considered as a drug of first choice and a welcome addition to the drug armamentarium for the symptomatic treatment of NUD (non-ulcer Dyspepsia) and other gastric motility disorders including functional bowel disorders. This review consists of various analytical methods for determination of Itopride Hydrochloride in various marketed pharmaceutical preparation and in biological fluids. Analytical method consists of various spectroscopic methods, chromatographic methods and other methods.

Gujarat Technological University (G.T.U) invites applications for contract based (for 6 months) Assistant Professor (IPR/Patents), Research Assistant(IPR), Research Assistant(Pharmacy). Eligibility/other details & application format may be downloaded from website: gtu.ac.in. Filled application should reach the University Office by 25-08-2014 (Except public holidays). The date of personal interview & shortlisted candidates will be declare on GTU website in recruitment section.

Post: Assistant Professor (IPR/Patents), Research Assistant

Military Station Bhuj invites application for contractual employment of medical staff/ pan medical staff/ group D staff for an Ex-servicemen contributory health scheme(ECHS) polyclinic (Type D) at military station bhuj (Kutch) gujarat as per the following details:

Post: Pharmacist

The following post is to be filled up under time bound research project entitled Investigation of factors affecting in vitro fertilization” at division of Reproductive and Cytotoxicology, at National Institute of Occupational Health, Ahmedabad. The post is purely temporary, ad-hoc & contractual basis and co-terminus with the project:

Post: Project Assistant (One)

One of the fastest growing consulting, training and placement company with PAN India and Global presence. With 5 Branches in india and one at Mauritius

Post: HR Recruiter

The Smt. N. M. Padalia Pharmacy College offers the four year Degree in Pharmacy (B.Pharm). The institute admits 60 students for B.Pharmacy course (PCI approved). The bachelors follows well defined curriculum in theoretical and practical aspects of pharmaceutical sciences according to the norms and standards of the All India Council of Technical Education (AICTE) and Pharmacy council of India (PCI).

Post: Principal, Professor, Associate Professor, Assistant Professor