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20 January 2017

NANO-PARTICLES CONTAINING ANTICANCER DRUG

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ABOUT AUHTORS
Debpratim Chakraborty*, Nisha Lama Yolmo
Department of Pharmaceutical tech,
Jadavpur University,
Kolkata, West Bengal, India
*debpratim008@gmail.com

ABSTRACT:
Now a day in medical science and researches, cancer is one of the most life threatening disease but unfortunately still now we have no medical treatment for procurement of this disease. The pathology is not totally clear but according to medical evidence if we consider genes then we must agree that oncogene and tumor suppressor genes are mainly responsible. There are some risk factor also consider which may leads to cancer. The conventional treatments are surgery, Radio-therapy and chemo therapy but the real fact is none of the above mentioned treatment is enough for procurement of cancer and that’s why now scientist and researchers are thinking about nan-technology. NCI has identified that nano-technology have the potential to make paradigm changing impacts on the detection, treatment and prevention of cancer. There are different strategies for cancer therapy using nano-particles like targeted and non-targeted nano-particles. Different studies show that the side effect of doxorubicine (an anticancer drug) can be minimizing by nano-technology, which also reduce the multi drug resistance. Nano-sphere and Nano-capsule of anti-steroid 4-hydroxytamoxifen RU reduce estrogen dependent tumor. Dendritic nano-technology with 5-fluro Uracil decreases the drug clearance and increase the therapeutic time. Methotrixate incorporated dendritic polymer target the folic acid receptor. Camptothecin loaded nano-particles show longer plasma retention, high and longer tumor localization. Nano-particles prepared by poly-lactic-co-glycolide increase the half life of Cisplatin. Paclitaxel, a microtubule-stabilizing agent that promotes polymerization of tubulin causing cell death by disrupting the dynamics necessary for cell division, is effective against a wide spectrum of cancers. Miscellaneous agent like Arsenic trioxide, Butyric Acid, Diethylene-triamine-Acetic acid show more prominent activity. Recent development in nanoparticle-based combination therapy have shown several unique features that are untenable in traditional chemotherapy. Drug combinations can now be optimizedand cleverly delivered in a more effective way.
29 December 2016

PREPARATION AND IN-VITRO EVALUATION OF DICLOFENAC SODIUM TRANSDERMAL PATCHES

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ABOUT AUHTOR
SUSMITA DAS*
Department of Pharmaceutical Technology,
Jadavpur University,
West Bengal, India
*sdas53662@gmail.com

ABSTRACT:
Objectives: The aim of the present study was to develop transdermal matrix patches with a fixed ratios of polyvinylpyrrolidone (PVP) and ethylcellulose (EC), containing the drug diclofenac sodium and to perform the physicochemical, in vitro relese pattern evaluation of the prepared patches. The prospective objective was the demonstration that the system provides the delivery of drug at a controlled rate across intact skin to achieve a therapeutically effective drug level for a longer period of time from transdermal patches.
Methods: In this study, matrix-type transdermal patches containing diclofenac sodium were prepared using different ratio of polyvinylpyrrolidone (PVP) and ethylcellulose (EC) by solvent evaporation technique. The drug matrix film of PVP and EC was casted on a polyvinylalcohol backing membrane. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, and flatness), and in-vitro release kinetics and permeation studies were performed across cadaver skin using a modified diffusion cell.
Results and conclusion: Variations in drug release profiles among the formulations studied were observed. From the formulated patches FA 1, containing PVP/EC in ratio of 1:3 shows sustained release action with 38% release after 24 h and 10 µg of drug permeation accross 1 cm² of patch area. Hence, it can be reasonably concluded that diclofenac sodium can be formulated into the transdermal matrix type patches to sustain its release characteristics for manufacturing transdermal patches of diclofenac sodium
14 December 2016

Jadavpur University invites applications for Guest Faculties

Jadavpur University is to trace a part of India’s freedom movement, at least from the Swadeshi Movement onwards. It was 1905 -1906. Bengal stood divided. The times were feverish.The hegemony of the British establishment had to be challenged. Education had to play a new role in this changed scenario. It had to become a new form of resistance through which the emergent nationalist spirit could be propagated.

The University invites applications from Indian Nationals in the prescribed form for Guest Faculties to teach the subjects mentioned for each department in the Second Semester of the (2016-2017) academic session in various Departments of Faculty of Engineering & Technology.
20 November 2016

Recruitment for M.Pharm, M.Sc at Jadavpur University - 6 posts | walk in jobs

To trace the history of Jadavpur University is to trace a part of India’s freedom movement, at least from the Swadeshi Movement onwards. It was 1905 -1906. Bengal stood divided. The times were feverish.The hegemony of the British establishment had to be challenged. Education had to play a new role in this changed scenario. It had to become a new form of resistance through which the emergent nationalist spirit could be propagated. With this in mind the National Council of Education (NCE) came into being
19 November 2016

Job in research as JRF at Jadavpur University | M.Pharm

To trace the history of Jadavpur University is to trace a part of India’s freedom movement, at least from the Swadeshi Movement onwards. It was 1905 -1906. Bengal stood divided. The times were feverish.The hegemony of the British establishment had to be challenged. Education had to play a new role in this changed scenario. It had to become a new form of resistance through which the emergent nationalist spirit could be propagated. With this in mind the National Council of Education (NCE) came into being.

Post: Junior Research Fellow
5 February 2016

Recruitment for the post of Research Fellow at Jadavpur University | 14 Posts

To trace the history of Jadavpur University is to trace a part of India’s freedom movement, at least from the Swadeshi Movement onwards. It was 1905 -1906. Bengal stood divided. The times were feverish.
The hegemony of the British establishment had to be challenged. Education had to play a new role in this changed scenario. It had to become a new form of resistance through which the emergent nationalist spirit could be propagated. With this in mind the National Council of Education (NCE) came into being.
15 January 2016

Walk in interview for Project Fellow in Jadavpur University

To trace the history of Jadavpur University is to trace a part of India’s freedom movement, at least from the Swadeshi Movement onwards. It was 1905 -1906. Bengal stood divided. The times were feverish.The hegemony of the British establishment had to be challenged. Education had to play a new role in this changed scenario. It had to become a new form of resistance through which the emergent nationalist spirit could be propagated. With this in mind the National Council of Education (NCE) came into being.
4 December 2015

NATIONAL SEMINAR ON Drug and diseases: role of pharmacists and doctors at Jadavpur University

National Seminar on “Drug and diseases: role of pharmacists and doctors” is going to be organized jointly by the Centre for Advance Research in Pharmaceutical Sciences, Department of Pharmaceutical Technology, Jadavpur University, Kolkata and the Indian Association of Pharmaceutical Scientists and Technologists, Kolkata on 16th January, 2016 at Dr. H. L. Roy Building, Jadavpur University (Kolkata 700 032), one of the premier universities in India.
14 September 2015

EFFECT OF PULSATILLA ON POLYCYSTIC OVARIAN SYNDROME AND ITS ASSOCIATED CANCER

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ABOUT AUTHORS:
Debpratim Chakraborty
Persuing M.Pharm (Pharmacognosy),
Jadavpur University, West bengal.
debpratim008@gmail.com

ABSTRACT
Polycystic Ovarian Syndrome is one of the most common female endocrine. Many papers reported the correlation between infertility that most eminently predisposes towards cancer in PCOS women from many years. From both clinical and experimental research one can conclude that correlation between PCOS and endometrial cancer is the strongest. Most studies on correlation between PCOS and ovarian cancer as well as breast cancer failed to show a link though Pulsatilla have a strong effect on it. Various synthetic drugs which mainly used in the treatment of PCOS and endometrial cancer but here the problem is those drugs has lots of side effect/Adverse effect so we should go with the natural product Pulsatilla Sp. Which is used on PCOSand various cancer. Pulsatilla is a well establish drug for PCOS with unknown mechanism of action. Deoxypodophyllotoxin, which was isolated from the roots of P. koreana, was found to inhibit the tube-like formation of HUVECs (human umbilical venous endothelial cells) and have a potent antitumor effect. The chemical constituent saponin D present in Pulsatilla root is responsible for the anti tumor activity. The results, which are expressed as Pulsatilla saponin D has such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). 23-Hydroxybetulinic acid synthesized from Pulsatilla chinensis also shows anti tumoral activity. Though the potency of pulsatilla sp. Are less than synthetic marketed drugs but by structural modification we may get potent anti canceral agent with least toxicity by Pulsatilla.
13 July 2015

Walk in interview for Research Assistant in Jadavpur University

A walk in interview will be held at the Office of the Director, School of Natural Product Studies, jadavpur University on july 16, 2015 (Day) at 2:30 p.m. tor the following position to carry on research work in "DBT - TATA Innovation Fellowship" sponsored by Department of Biotechnoiogy. Ministry of Technology, Govt, of India. This research project work Entitled *'Met abalomic study: tools for qunfity evaluation and validation of Medicinal Plants used in Indian Systems of Medicine’. under the supervision of Dr. Pulsk K. Mukherjee, Principal Investigates of the project and Director of the School of Natural Product Studies, jadavpur University as per following detail:

Post: Research Assistant