World University of Bangladesh

About Authors:
Zubair Khalid labu^1*, Mir Md. Abdullah Al –Mamun¹, Abdul Kader Mohiuddin¹, Razia Sultana Sumi¹, Md. Abdul Bake^2
1Department of Pharmacy, World university of Bangladesh, Dhaka-1205, Bangladesh
²Department of Pharmacy, Gono University, Savar, Dhaka-1344, Bangladesh.
*zubairlabu@yahoo.com

Abstract
The present study was designed to investigate the antioxidant activity of ethyl acetate, methanol and chloroform extract of barks of Xylocarpus mekongenesis (Lamk.). 1,1-Diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging and nitric oxide scavenging were used for determining antioxidant activities. In DPPH free radical scavenging test, IC₅₀ value for methanol extract of Xylocarpus mekongenesis was found fairly significant 8.76±0.05 μg/ml when compared to the IC₅₀ values of the reference standards were ascorbic acid 3.41±0.07μg/ml and Butylated Hydroxyanisole 6.29±0.06μg/ml. The IC₅₀ values of the methanol extract and ascorbic acid were 55.88 ± 0.09 and 36.81 ±0.06 μg/ml, respectively in nitric oxide scavenging assay. Phytochemical screening of the bark extract indicated the presence of carbohydrate (reducing sugars), glycosides, saponins, tannins and flavonoids.Therefore, the obtained results suggest the antioxidant activities of the barks of Xylocarpus mekongenesis and thus provide the scientific basis for the traditional uses of this plant part as a remedy for inflammations.