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Clinical research courses

  • Career for M.Pharm, M.Sc in Department of Clinical Pharmacology at SRM Medical College Hospital & Research Centre

    Applications are invited for suitable candidates for the position of Senior Research Fellow (SRF) to work on the following ICMR sponsored research project titled “Evaluation of Evaluation of a Multi-Marker Strategy to Prognosticate patients with Acute coronary Syndrome” under the supervision of Dr. Melvin George, Assistant Professor, Department of Clinical Pharmacology, SRM Medical College Hospital & Research Centre, Kattankulathur-603202, Kancheepuram

    Post: Senior Research Fellow

  • CLINICAL PHARMACIST SPECIALIZED CARE IN MANAGEMENT OF CONGESTIVE HEART FAILURE - A BRIEF REVIEW

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS
    M.S.Umashankar*1, K.S.Lakshmi, A.Bharath Kumar, A.Porselvi
    SRM College of Pharmacy,
    SRM University, Kattankulathur,
    Tamil Nadu, India

    *abharatpharma@gmail.com

    ABSTRACT : 
    It is a critical clinical condition in which more abnormalities in cardiac structure and its functions may impact the ineffectiveness of the heart to supply required oxygen to meet the cellular metabolic demands of the body. Heart is covered with protective layers and express the various functions in the body. Clinically cardiac disease prevalence rises with individual age. Cardiac dysfunction happens because of changes in blood volume, and neurohumoral transmission status. These desirable mechanisms to maintain adequate cardiac output and arterial blood pressure. The neurohumoral responses act as compensatory mechanisms and provokes heart failure by increasing ventricular after load and increasing preload,which further elevates the cardiac failure. Health care system with a clinical pharmacist is well allocated to impact the disease management through identification of risk factors, stage of severity, educating the patients and health care practioners and implementing the awareness programmes, modification of life style interventions with in health care system beneficial to the community may reduce the progression of disease severity.

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  • Application are invited for Professors, Associate Professors, Assistant Professors and Lecturers at SRM University

    SRM University is one of the top ranking universities in India with over 38,000 students and more than 2600 faculty across all the campus, offering a wide range of undergraduate, postgraduate and doctoral programs in Engineering, Management, Medicine and Health sciences, and Science and Humanities. 
    SRM University, one of the top private universities in India, invites applications for its faculty positions at all levels.

    Post:  Professors, Associate Professors, Assistant Professors and Lecturers

  • STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR CINACALCET HYDROCHLORIDE API

    About Authors:
    Gautam Kumar
    SRM college of pharmacy, SRM University
    Chennai 600 033.
    gautamsinghsrmcp@gmail.com

    Abstract
    The aim of the present work to develop validated RP-HPLC method which determines stress stability and concentration of Cinacalcet hydrochloride in synthetic mixture as per ICH guidelines. Separation was performed using Camag Linomat V semi Automated sample applicator with TLC Scanner III. Stationary Phase consisting of TLC plates (Merck) pre coated with silica gel 60F254 on Aluminum Sheets was used. Mobile phase comprising of Methanol: Water: Glacial acetic acid (5:5:0.2v/v/v) was used. All the system suitability parameter was found within the range. The method was extensively validated for specificity, linearity, accuracy, precision, recovery, limit of quantitation and detection. The Cinacalcet hydrochloride was found to be highly labile to alkaline and acid hydrolysis compared to oxidation. Chromatographic peak purity results indicated the absence of co-eluting peaks with the main peak of Cinacalcet, which demonstrated the specificity of assay method for estimation of Cinacalcet in presence of degradation products. The proposed method can be used for routine analysis of Cinacalcet in quality control laboratories.

  • DEVELOPMENT AND VALIDATION OF QUETIAPINE BY HPTLC METHOD

    About Author:
    Gautam Kumar
    SRM college of pharmacy,SRM University
    Chennai 600 033.
    gautamsinghsrmcp@gmail.com

    Abstract
    The aim of the present work is to develop validated HPTLC method which determines stress stability and concentration of Quetiapine and its formulation as per ICH guidelines. Separation was performed using Camag Linomat V semi Automated sample applicator with TLC Scanner III. HPTLC analytical measurement and separation were performed using Stationary Phase consisting of TLC plates (Merck) pre coated with silica gel 60F254 on Aluminum Sheets was used. Mobile phase comprising of Methanol: Toluene (7:3 v/v) was used. All the system suitability parameter was found within the range. Area under curve was measured at 235nm. The method was extensively validated for specificity, linearity, accuracy, precision, recovery, limit of quantitation and detection. The proposed method can be used for routine analysis of Quetiapine in quality control laboratories.

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