Parul Institute of Pharmacy

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ABOUT AUTHORS
Khushbu Patel¹, Divya chauhan¹, Rabiya Sodha¹, Kinjal Vadhwani¹, Kapil Daxini²
Department of pharmacy
¹Parul Institute of Pharmacy, Waghodiya, Limda, Vadodara, Gujarat
²Sigma Institute of Pharmacy, Bakrol, Vadodara, Gujarat

ABSTRACT
Proteins and peptides are mostly desirable in many diseased states. Most widely employed method of administration for therapeutic proteins and peptides is Parenteral route. Requirement of repeated injections is because of short in vivo half-life response in poor patient compliance. Non-invasive drug delivery routes such as nasal, transdermal, oral, and pulmonary offer several benefits over parenteral administration. Low permeability and intrinsic physicochemical properties across biological membrane limits protein delivery via adjective routes. Delivering through nanostructured delivery carriers is one of the method to improve protein and peptide absorption. Polymeric nanoparticles (NPs) have illustrated significant benefits over other delivery systems. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following nasal, oral, ocular, pulmonary, transdermal, and parenteral administrations. The aim of review is to highlight and explore technological developments in the field of soft matter nanocarriers for the delivery of proteins and peptides via the eye, the nose, the skin, and the lungs and to provide insights in advantages, practicability and limitations of recent advances.

Parul University is a legitimate university established under Gujarat Private University Act 2009, after legislation passed by the Government of Gujarat on 26th March 2015 giving University status to Parul Group of Institutes functioning under the aegis of Parul Arogya Seva Mandal Trust. Parul University is an amalgamation on 28 Institutes offering 100+ programs in Engineering & Technology, Pharmacy, Physiotherapy, Homoeopathy, Ayurveda, Architecture, Management, Business Administration, Computer Application, Fine Arts, Social Work and Vocational Education at Diploma, Under Graduate, Post Graduate & Doctoral Level in a 150+ acre fully equipped campus housing 25000+ students, 300+ International Students from 26 Different Countries, 2000+ faculty members & providing in-campus residential facility to 7000+ students making it India’s Premier Multidisciplinary University.

About Parul Institute of Pharmacy
Parul Institute of Pharmacy was established in 2004. The institute is approved by the All India Council for Technical Education (AICTE) and Pharmacy Council of India (PCI), New Delhi and recognized by the Government of Gujarat. The institute was accredited by the National Assessment and Accreditation Council (NAAC) and the National Board of Accreditation (NBA), manifesting its commitment to provide quality teaching- learning and research. The institute is housed in sprawling lush green campus with an imposing building and most conducive atmosphere for academic excellence. The state-of-the-art infrastructure and instructional facilities of the institute includes well- equipped laboratories, voluminous library and spacious lecture halls. Parul Institute of Pharmacy is amongst the top ranking institutes in Gujarat. The Institute has grown impressively in both size and reputation and has become the preferred choice for many among all other self-financing institutes. At Parul Institute of Pharmacy, we provide our students with distinguished knowledge and top class facilities to meet the highest benchmarks. We have well experienced and learned faculty, scholastic curriculum, diverse educational exposure and various on-campus facilities which collectively focuses on all round learning experience and rewarding opportunities forthe students.

The aim of the present work is to formulate pellets by a novel freeze pelletization technique.

Objective:-
*To prepare matrix pellets of  drug Losartan.
*To sustain the release of drug from the pellets.
*To evaluate the pellets for various characteristics.

“Parul group of Institutes” is a multidisciplinary hub of 19 self financed institutions with more than 15000 students and a thousand eminent faculty members.

About Authors:
Shah Chirag K.*, Umalkar Deepak, Dr. Rajesh KS.
Parul Institute of Pharmacy, Gujarat University,
Waghodia-391760, Dist. Vadodara,
Gujarat, India.
*cks2484@gmail.com

Abstract:
The present manuscript described the simple, rapid, accurate, sensitive, precise and economical Q- absorption ratio method for simultaneous determination of Cefixime and Moxifloxacin in combined tablet dosage form. Absorption ratio method uses the ratio of absorbances at selected wavelengths, one which is isoabsorptive point and other being the λ_max of the one of the components. Cefixime and Moxifloxacin shows isoabsorptive point at 275nm in 0.1N HCl. The second wavelength used is 295nm, which is λ_max of Moxifloxacin. The concentrations of the drugs were determined by using ratio of absorances at isoabsorptive point and at λ_max of Moxifloxacin. The method successfully applied to the Pharmaceutical formulation because no interference from the tablet formulation excipients was found. The results of analysis have been validated statistically and by recovery studies.