Amity University

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools and pre-schools, 150 top-ranked institutions and 12 international campuses across the globe.  One of India’s leading education groups, Amity is home to over 125,000 students pursuing 300 Programmes in 60 diverse disciplines across pre-school to Ph.D.  The 4500 strong faculty have the distinction of filing the highest number of patents in the last years, besides developing the highest number case studi

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools & pre-schools, 150 top-ranked institutions and 12 international campuses across the globe.  One of India’s leading education groups, Amity is home to over 125,000 students pursuing 300 Programmes in 60 diverse disciplines across pre-school to Ph.D.  The 4500 strong faculty have the distinction of filing the highest number of patents in the last years, besides developing the highest number case studies in the last one year. The faculty is also carrying out over 300 sponsored research projects with leading Govt. bodies like CSIR, DRDO and global institutions like Bill & Milinda Gates Foundation. These unique initiatives are reflected in Amity being recognised as SIRO (Scientific & Industrial Research Organisation) by the Govt. of India.

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools & pre-schools, 150 top-ranked institutions and 12 international campuses across London, Singapore, New Jersey, Dubai, Mauritius, Romania, Abu Dhabi, South Africa and China.

Applications are invited from highly motivated and bright candidates for the following assignment on a purely time-bound research project undertaken in the Amity Institute of Pharmacy, Lucknow Campus.

Post : Junior Research Fellow

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools & pre-schools, 150 top-ranked institutions and 12 international campuses across London, Singapore, New Jersey, Dubai, Mauritius, Romania, Abu Dhabi, South Africa and China.

Post : Project Associate

Applications are invited from highly motivated and bright candidates for the position of  Junior Research Fellow in the  DST-SERB sponsored Project titled as "Probing Microtubule Remodeling in Tumor Associated Macrophages and its implication for Microtubule-targeted Chemotherapy”

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools & pre-schools, 150 top-ranked institutions and 12 international campuses across London, Singapore, New Jersey, Dubai, Mauritius, Romania, Abu Dhabi, South Africa and China.

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools & pre-schools, 150 top-ranked institutions and 12 international campuses across London, Singapore, New Jersey, Dubai, Mauritius, Romania, Abu Dhabi, South Africa and China.

Post : Junior Research Fellow

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ABOUT AUTHORS
Abdul Waheed*, Swati Pathak, Roohi Mirza
Department of Pharmacology,
Amity Institute of Pharmacy,
Amity University, Noida, U.P., India
*abdul.waheed2050@gmail.com

ABSTRACT
Epilepsy is a chronic brain disorder characterized by tendency to recurrent seizures or fits. The seizures can leads to loss of consciousness, disturbance of movement, muscle spasms, autonomic and mental functions. Epilepsy is developed because of imbalance in nerve signalling chemical called neurotransmitters. During epilepsy, the level of excitatory neurotransmitter glutamate increases and the level of inhibitory neurotransmitter GABA decrease. These lead to abnormal signalling in brain causes epilepsy. Primary diagnosis of epilepsy includes eye–witness and family history. Electroencephalograph (EEG) is the cornerstone for diagnosis of epilepsy and measures the brain wave activity. Neuroimaging like computed tomography (CT) scan, magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques are used to diagnose abnormalities in structure and function of brain. Video recording is also useful for the monitoring of epileptic events. The most common approach of treatment is to prescribe antiepileptic drugs (AEDs). Three generations of AEDs including phenytoin, valproate, carbamazapine, lamotrigine, Oxcarbazepine, Primidone,Phenobarbitone,Gabapentin, Topiramate, Levetiracetam, Felbamate, Rufinamide, Zonisamide, Tiagabinand Vigabatrin etc. are prescribed. These AEDs have some teratogenic effects on  pragnent woman and lactating mother; need precautions. Instead of  pharmacological approaches, Non-pharmacological approaches also used for the treatment of epileptic seizures like ketogenic diet, atkins diet, yoga etc. Thr purpose of this review is to update the current knowledge on epilepsy classification, diagnostics, approaches of treatment, pathophysiology, mechanism of epileptogenesis and teratogenic effects.