Jalgaon

15 February 2013

SOLUBILITY DETERMINATION IN DRUG DISCOVERY AND DEVELOPMENT

About Author:
Dhananjay S Jadhav
*M Tech (Pharmaceutical Technology) Department of Pharmaceutical Technology,
University Institute of Chemical Technology,
North Maharashtra University,
Jalgaon -425001. Maharashtra, India.
dhananjaysjadhav@hotmail.com

Abstract
Solubility of drug candidate plays a vital role in selection of lead compound in early stage of drug development and discovery. Biopharmaceutical classification system distributes the drug candidate into different bins depending on the solubility and permeability. Two type of solubility determined at different stages of drug discovery, kinetic solubility and thermodynamic solubility. It is useful in deciding development plan and option of formulation development and to confirm result obtained from kinetic solubility data. Different problem encounter while determining the solubility, most of characteristics usually pH dependent, such as multiple and often overlapping ionization, complexation, aggregation, micelle formation, and “common ion” effect, incubation time, adsorption to micro porous filters, plastic or glass surfaces, polymorph interconversion. Above parameter should be considered while determining solubility. Different method available for measurement of the different solubility, conventional shake flask method now a day’s replaced by the high throughout solubility assay technique which considerably reduces the incubation time increased accuracy of result. Solubility determination can be done by ultraviolet absorption, nephlometry, Nuclear magnetic resonance and Potentiometric in drug discovery. The present review attempts to give a brief account of solubility and it’s importance, process of solubilisation, problems that occur while determining solubility, different types of solubility and there application, parameter to be considered while measuring solubility, different method to measure solubility, application in drug discovery in development, recent advances in solubility measurement.
3 December 2012

TASTE MASKING TECHNOLOGIES: A NOVEL APPROACH FOR THE BETTER PATIENT COMPLIANCE

About Authors:
Dhananjay S. Jadhav
M. Tech (Pharmaceutical Technology) Division of Pharmaceutical Technology,
School of Chemical Technology, North Maharashtra University,
Jalgaon- 425001, India
dhananjaysjadhav@hotmail.com

ABSTRACT
Oral administration of pharmaceuticals is one of the most popular method of drug dilevery.Taste is an important factor in the development of dosage form. “The worse the taste of the medication, the better the cure” was once the prevailing attitude. Many orally administered drugs elicite bitter taste. Undesirable and particularly bitter taste is one of the important formulation problems that are encountered with many drugs. Administration of bitter drugs orally with acceptable level of palatability is a key issue for health care providers. Proven methods for bitterness reduction and inhibition have resulted in improved palatability of oral pharmaceuticals. Several approaches like adding flavors and sweeteners, use of lipoproteins for inhibiting bitterness, coating of drug with inert agents, microencapsulation, multiple emulsion, viscosity modifiers, vesicles and liposomes, prodrug formation, salt formation, formation of inclusion and molecular complexes, solid dispersion system and application of ion exchange resins have been tried by the formulators to mask the unpleasant taste of the bitter drugs. The present review attempts to give a brief account of different technologies of taste masking with respect to dosage form and novel methods of evaluation of taste masking effect.

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11 November 2012

Area Sales Manager require in Synergy Diagnostics | All India Level

Synergy Diagnostics pvt Ltd, a Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.
8 November 2012

Work as Area sales Executive/Medical representative in Synergy Diagnostics - Freshers may apply

Synergy Diagnostics pvt Ltd, a Leading Bio-pharmaceutical company, with the Largest range of human blood plasma derived bio-pharmaceutical products, used in the prophylaxis & treatment of various life-threatening conditions.We are basically in to Sales & Marketing of imported products Manufactured from Human Blood. Products manufactured are injectable & critical care products.
25 September 2012

Trends in Chromatography and Spectroscopic Techniques ( 6th October, 2012 ) at R. C. Patel Institute of Pharmaceutical Education and Research
9 March 2012

WALK IN INTERVIEW: Opening for Field Sales Offiers, Product Specialists, First Line Manager in INTAS PHARMA - Multiplace vacancies | Freshers
14 February 2012

Stem Cells for Tissue Repair — A New Therapeutic Concept?

About Authors:
Dhananjay S.Jadhav¹,Vinod J Mokale¹ ,Ajit P Patil¹, Sujata S.Gaikwad²,
^1.Division of Pharmaceutical Technology,University Department of Chemical Technology,NMU,Jalgaon.Maharashtra.
^2.Swami vivekand education societys college of pharmacy chembur, Mumbai,Maharashtra.

Abstract
Stem cells are cells found in most of the multi-cellular organisms. They have ability to renew themselves through mitotic cell division and differentiating into a diverse range of specialized cell types.¹Once the healthy stem cells are infused into the patient's blood stream, the cells move from the blood vessels to the center of the bones where they begin making new blood cells. Starting from the beginning, cells are the basic unit of all life. They contain DNA , which is all of the cell’s genetic material. They also have the ability to undergo cell division and replication.The harvesting of stem cells from surplus embryos is prepared for in-vitro fertilization procedures in fertility clinics.“The cord in placental mammals that joins the embryo and the placenta together, where the placenta provides nutrients to the embryo via the umbilical cord while at the same time transporting the waste material from the baby.Stem cells are self- renewing cells.The supply of these cells is maintained by stem cells, which replicate many times and then differentiate into the specialized cells that are needed. In this way, cells are continuously replenished as they die. Stem cell application is a new field with lots of promises to offer. Stem cell research is a new field with unlimited scope. Stem cells hold the key to replacing cells lost in many diseases that are caused by loss of functioning cells. The unique capability of this cell to form various tissues under definite signals received from the body, makes this cell an of extensive research.
27 December 2011

Introduction to new chromatography technique - UPLC

About Authors:
Snehal V.Chopade, Dr.V.R.Patil - Principle
TVES College of pharmacy,
Faizpur accredited by North Maharashtra University,
Jalgaon

Abstract:
UPLC can be regarded as new invention for liquid chromatography. UPLC refers to Ultra Performance Liquid Chromatography. UPLC brings dramatic improvements in sensitivity, resolution and speed of analysis can be calculated. It has instrumentation that operates at high pressure than that used in HPLC & in this system uses fine particles(less than 2.5µm) & mobile phases at high linear velocities decreases the length of column, reduces solvent consumtion & saves time.
This review introduces the theory of UPLC, and it can summarizes some of the most recent work in the field.
14 December 2011

Require Area Sales Manager in Nextus Solutions

NEXTUS SOLUTIONS is a professionally managed organization engaged in offering highly acclaimed consulting, Training and Placement. With our in- depth expertise and rich experience in the field of domestic as well as international level, we have been serving aspiring candidatesand organizations in the most professional way. We have excellent support of varied resources for meeting the needs of the clients and candidates as per their exact requirements.
8 June 2011

Multiple vacancies in Panacea Biotec as Business Development Executives; Walk in Jobs - All India Level Posts | Freshers can apply

Panacea Biotec is a leading research based Health Management Company, with an annual turnover of approx. Rs. 830 Crores. We are engaged in research, development, manufacture & marketing of Vaccines, Bio-Pharmaceuticals and Pharmaceuticals (Rx & OTC) of international quality and Health Services. All Panacea Biotec plants are accredited by international agencies and they follow current Good Manufacturing Practices, as per WHO guidelines.We offer stimulating work environment & a career that spells growth.