Vellore

About Authors:
¹Shambhawi, ^*Sai Saraswathi V
^1*Pharmaceutical Chemistry Division,
School of Advanced Sciences,
VIT-University, Vellore-632014,
Tamilnadu, India.
¹shambhawi06@yahoo.co.in, * v.saisaraswathi@vit.ac.in

ABSTRACT :
Standardization of polyherbal formulation is important to validate the quality of drugs and to ensure that the consumers are getting medication which guarantees purity, safety, potency and efficacy. The present paper reports standardization of traditional ayurvedic liquid polyherbal antidiabetic formulation (Sucrogen) and diabetes survey for retrieving the information on medication along with the lifestyle of diabetic population. Sucrogen was standardized based on ayurvedic pharmacopeia physico-chemical properties, preliminary phytochemical tests, organoleptic characters, stability studies, microbial studies, TLC, HPLC, heavy metal estimation by AAS and flame photometry to fix the quality standard of this drug. Invitro anti-diabetics activity of the drug was determined using alpha amylase Inhibitory method.These studies resulted in a set of diagnostic characters essential for its standardization. The phytochemical constituents found to be present in raw materials used for the preparation of Sucrogen possibly helps in achieving the desirable therapeutic efficacy of the ayurvedic formulation.
OBJECTIVE
To do a general survey on diabetes and to standardize the polyherbal formulation consumed by the population of Jharkhand for the determination of purity and quality of drug

About Authors:
SHAMBHAWI*, M SHIVASHANKAR
School of Advanced Sciences, Pharmaceutical chemistry division,
VIT University, VELLORE
India

ABSTRACT:
Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. Hydrogels are a unique class of macromolecular networks that can hold a large fraction of an aqueous solvent within their structure. The objective of this paper is to give a brief review on the fundamentals and recent advances in chitosan based hydrogel for e.g., thermosensitive hydrogel variants which precludes the need of surgical implantation as well as the description of the release mechanism of bioactive molecules from these hydrogels which traps a drug and then releases the active compound by "Swelling" or expanding inside of specific tissues, thus allowing a higher concentration of the drug in a biodegradable format. This article presents an overview of the newest developments and applications of Chitosan based hydrogel for controlled drug delivery system.