Pharmaceutical company Novartis has announced plans to cut up to 400 jobs from its Dublin operations The changes will take place over the next two years at its Global Service Centre at Elm Park in Dublin.
The company said the development was a strategic decision and resulted from an ongoing review of its operations in many locations.
It added that the centre will continue to play a critical role, focused on commercial and scientific operations.
"Novartis recognises that announcing such an intention has a significant impact on people and creates uncertainty," it said in a statement.
Currently, there are around 1,000 people employed at the centre, but this could reduce to 600 over time, it said.
Deputy prime minister of the Republic of Ireland said, “I extend my sympathies to all Novartis employees who have been affected by today’s announcement. Although the jobs losses are not unexpected, I know it will come as a major blow to workers and their families. “I’m glad to see that Novartis has reiterated its commitment to Ireland, recognising the high quality of our workforce and that it will keep employees informed in as transparent and timely a manner as possible.