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  • Working Opportunity as Clinical Data Analyst in Parexel

    PAREXEL has supported the Bio-Tech and Pharmaceutical industries in helping the development of new drugs and treatments on a global basis. As a leading global biopharmaceutical service provider, they supply knowledge-based contract research, medical communications and consulting services across a broad range of therapeutic areas to the worldwide pharmaceutical, biotechnology and medical device industries. They have helped over 800 clients to develop and launch some of the most important drugs and devices of our time-helping people live better and healthier lives everywhere in the world. Headquartered near Boston, Massachusetts, PAREXEL operates in more than 50 countries around the world.

    Post: Clinical Data Analyst II

  • Vacancy for Senior Research Scientist I- Medchem in AMRI
    Vacancy for Senior Research Scientist I- Medchem in AMRI

    For more than 20 years, as Albany Molecular Research Inc. (AMRI), we have provided fully integrated drug discovery, development and manufacturing services – all while adapting to the rapidly changing needs of our customers within the pharmaceutical, biotechnology and related industries.
    With locations in the United States, Europe and Asia, AMRI SMARTSOURCING™ offers you a versatile and strategic way of partnering with us that is designed to deliver reduced risk, greater flexibility and a better return on investment. AMRI has successfully partnered R&D programs and is actively seeking to out-license its remaining programs for further development.

    Post: Senior Research Scientist I- Medchem - (1648)

  • Walk in lnterview for M.Pharm/M.Sc as Project Assistant, Junior Research Fellow in IICT - 10 posts
    Walk in lnterview for M.Pharm/M.Sc as Project Assistant, Junior Research Fellow in IICT - 10 posts

    Indian Institute of Chemical Technology (IICT), Hyderabad, a constituent of CSIR is a leading research Institute in the area of chemical sciences. The core strength of IICT lies in Organic Chemistry, and it continues to excel in this field for over six decades. The research efforts during these years have resulted in the development of several innovative processes for a variety of products necessary for human welfare such as drugs, agrochemicals, food, organic intermediates, adhesives etc. More than 150 technologies developed by IICT are now in commercial production.

    CSIR-IICT is conducting Walk-in-lnterview for the following positions on a purely temporary basis for the sponsored projects at 10.00 A.M on 15th May 2014 at IICT Hyderabad:

    Post: Project Assistant, Junior Research Fellow

  • Invitation for the post of Senior Medical Writer in Novartis
    Invitation for the post of Senior Medical Writer in Novartis

    A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

    Post: Senior Medical Writer

  • Vacancy for Associate Regional Manager in ThermoFischer Scientific
    Vacancy for Associate Regional Manager in ThermoFischer Scientific

    We’re a global biotechnology company dedicated to improving the human condition. Our industry-leading brands are found in nearly every life sciences lab in the world, including innovative instrument systems under the Applied Biosystems and Ion Torrent names. We’re also responsible for a broad range of reagents with our Invitrogen, GIBCO, Ambion, Molecular Probes and Taqman products. With approximately 3,900 patents and exclusive licenses, we’re home to one of the largest intellectual property estates in the life sciences industry

    Post: Associate Regional Manager

  • Vacancy for Principal Business Analyst in Parexel
    Vacancy for Principal Business Analyst in Parexel

    PAREXEL has supported the Bio-Tech and Pharmaceutical industries in helping the development of new drugs and treatments on a global basis. As a leading global biopharmaceutical service provider, they supply knowledge-based contract research, medical communications and consulting services across a broad range of therapeutic areas to the worldwide pharmaceutical, biotechnology and medical device industries. They have helped over 800 clients to develop and launch some of the most important drugs and devices of our time-helping people live better and healthier lives everywhere in the world. Headquartered near Boston, Massachusetts, PAREXEL operates in more than 50 countries around the world.

    Post: Principal Business Analyst

  • Requirement for Assistant Manager- Quality Assurance in Mylan
    Requirement for Assistant Manager- Quality Assurance in Mylan

    Mylan is one of the world’s leading generics and specialty pharmaceutical companies, providing products to customers in more than 150 countries and territories. The company maintains one of the industry’s broadest and highest quality product portfolios, which is regularly bolstered by an innovative and robust product pipeline. With a workforce of more than 16,000, Mylan has attained leading positions in key international markets through its wide array of dosage forms and delivery systems, significant manufacturing capacity, global commercial scale and a committed focus on quality and customer service.

    Post: Assistant Manager- Quality Assurance

  • Vacancies for B.Sc, B.Pharm as ZSM/RSM, ASM, FSO in Marc Laboratories
    Vacancies for B.Sc, B.Pharm as ZSM/RSM, ASM, FSO in Marc Laboratories

    Marc Laboratories Limited is the fastest growing Multidivisional Pharma Company. Under our expansion plan in Cardiac, Diabetic, Neuro & Pharma Divisions. We need suitable candidates at various locations in U.P., Uttaranchal, Delhi, Haryana, Rajasthan, West Bengal, Andhra Pradesh Jamilnadu, Kerala, Gujrat & Karnataka.

    Post: ZSM/RSM, ASM, FSO

  • Working opportunity in Mylan as Head of Quality Systems & Compliance, Injectables
    Working opportunity in Mylan as Head of Quality Systems & Compliance, Injectables

    Mylan is one of the world’s leading generics and specialty pharmaceutical companies, providing products to customers in more than 150 countries and territories. The company maintains one of the industry’s broadest and highest quality product portfolios, which is regularly bolstered by an innovative and robust product pipeline. With a workforce of more than 16,000, Mylan has attained leading positions in key international markets through its wide array of dosage forms and delivery systems, significant manufacturing capacity, global commercial scale and a committed focus on quality and customer service.

    Post: Head of Quality Systems & Compliance, Injectables

  • PREPARATION AND EVALUATION OF MATRIX TABLETS CONTAINING AMBROXOL HYDROCHLORIDE
    PREPARATION AND EVALUATION OF MATRIX TABLETS CONTAINING AMBROXOL HYDROCHLORIDE

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Soma Vinisha*, Sajida Akhtari Begum, Nikhat Tabassum, Soma Anusha
    Department of pharmaceutical science,
    Bharat Institution of Techology, Hyderabad, India
    choti.reddy@gmail.com

    ABSTRACT
    Purpose:
    This study aimed to formulate Ambroxol hydrochloride SR matrix tablets using xanthan gum (natural polymer) and to elucidate the release kinetics of Ambroxol hydrochloride from xanthan gum-matrices. Methods: controlled release matrix tablets of ambroxol hydrochloride, a mucolytic expectorant  were prepared by wet granulation method using xanthan gum as natural hydrophilic polymer in three different ratios (Drug : Polymer 1:1(F-1), 1:1.5(F-2), 1:2(F-3)). The prepared granules of three different formulations were evaluated for angle of repose, bulk density (BD), tapped density (TD) and compressibility index (CI), hausners ratio. The prepared tablets were tested for physical parameters like weight variation, hardness, friability, content of active ingredient and In-vitro drug release studies. Results: The results obtained were within the prescribed limits. The release of ambroxol from the matrix tablets was sustained up to 12hrs. The cumulative percentage of drug release was decrease with increase in polymer concentration. Among the three formulations F-3 gave the release profile close to the commercially available marketed sample of ambroxol Hcl (A-MS).The results indicate that the drug release from the matrix tablets followed Zero order kinetics. The dissolution data was fitted to Korsmeyer equation which is used to describe the drug release behaviour from polymeric systems. All the formulations showed diffusion co-efficient value (n) greater than 0.43 but less than 0.85 after fitting to the Korsmeyer equation. So, it indicates Non-Fickian transport mechanism. Therefore the drug release is by diffusion and erosion mechanism. Conclusion: Matrix tablets of Ambroxol Hydrochloride using xanthan gum prepared by wet granulation method were found to be good in appearance. The drug-polymer ratio was found to influence the release of drug from the formulations. Formulation F-3 i.e. (1:2 drug: polymer) exhibited the similar In-vitro drug release rates as that of the marketed sample.

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