About Authors:
Dinesh Kumar Jain*, Gajanan Darwhekar, Kapil Mahesh Dutt Swami
College of Pharmacy,
IPS Academy, Rajendra Nagar,
AB Road, Indore.
M.P. India.
*swamikpl@yahoo.com
ABSTRACT
Dandruff and seborrheic dermatitis are the common clinical conditions caused by increased growth of fungi and bacteria on the scalp which results in abnormal proliferation, scaling and flaking of scalp epidermis. In present study an attempt was made to develop hair styling gel of Fluconazole, zinc pyrithione and their combination using different concentration of carbopol 940. The formulations were evaluated and compare for rheology, pH, active content, in vitro drug release, ex vivo drug release, in vitro antidandruff activity and in vivo antidandruff activity. All the formulation are homogenous, transparent and stable but formulation HG1, HG7 and HG11 shows high clarity, optimum rheology, high drug content and drug release, so these three formulations were evaluated for in vitro antidandruff activity. HG11 shows higher zone of inhibition then HG1 and HG7 therefore HG11 was selected for skin irritation test, in vivo study and stability study. HG11 does not show any skin irritation hence it could be an effective formulation for treatment of dandruff and seborrheic dermatitis as compare to other.