About Authors:
Purbajit Chetia*, Manash Pratim Pathak, Prerona Das
Deptt. of Pharmacology,
Himalayan Pharmacy Institute, Majhitar,
Rangpo, E- Sikkim(737132)
*purbasiv@yahoo.com

ABSTRACT:
A free radical is an atom or group of atoms that contains at least one unpaired electron and can easily bond with another atom or molecule, causing a chemical reaction. Free radical is essential for body’s normal physiological functions. But when produced in excess quantities it can causes damage to the cells of the body. Human body generates pro-oxidants in the form of ROS and RNS which are effectively kept in check by the various levels of antioxidant defense. However, when it gets exposed to adverse physicochemical, environmental or pathological agents this delicately maintained balance is shifted in favor of pro-oxidants resulting in ‘oxidative stresses’. It has been implicated in the etiology of several human diseases including Rheumatoid Arthritis (RA) and in the process of ageing.At high concentrations, ROS can be important mediators of damage to cell structures, nucleic acids, lipids and proteins in case of the patients those who are suffering from RA. The hydroxyl radical is known to react with all components of the DNA molecule, damaging both the purine and pyrimidine bases and also the deoxyribose backbone.  Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and tissue around the joints with infiltration of macrophages and activated T cells. The pathogenesis of this disease is linked predominantly with the formation of free radicals at the site of inflammation. The review is focusing the evidences concerning the involvement of free radicals in Rheumatoid Arthritis and their relationship to specific pathophysiological events.

In October 1990 the B. V. Patel Education Trust in conjuncture with the Indian Pharmaceutical Association established B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre, in the memory of late Mr. B. V. Patel, the first Drug Controller of Gujarat.

The State of Kerala was formed on 1st November 1956 consequent on the Reorganisation of States. It comprises the former Travancore-Cochin State (except the present Kanyakumari District and Shencottah Taluk of the present Tamil Nadu) and the Malabar District and the Kasargod Taluk of South Kanara District of the then composite Madras State.

The Company (Manufacturing Ayurvedic and Unani Medicines) having obtained drug licence from licensing authority (G.M.P.

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology,

The National Institute of Oceanography (NIO) with its headquarters at Dona Paula, Goa, and regional centers at Kochi, Mumbai and Visakhapatnam, is one of the 38 constituent laboratories of the Council of Scientific & Industrial Research (CSIR), New Delhi. NIO was established on 1 January 1966 following the International Indian Ocean Expedition (IIOE) in early 1960s.

Saroj Educational Group (SEG) is self financed educational group offering highest standard of quality education of students across India.

About Author:
NITESH.P.SHARMA, AJAY.GUPTA
IDEAL COLLEGE OF PHARMACY AND RESEARCH, KALYAN
MUMBAI UNIVERSITY
Sharmanitesh479@yahoo.com

ABSTRACT:
The antibacterial activity of essential oils and their derivatives has been recognized for a long time. In the present study, the antibacterial properties of the essential oils obtained from the seeds of Seseli indicum, of Apiaceae family a wild weed found in the flood prone area of river Tapti, Gorakhpur (India). The essential oil obtained from seed was 3.4%. Essential oils were investigated for activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis using a punched-hole method. Essential oils inhibited all bacteria at both, low and high concentration. The results of this study confirmed the possibility of using Seseli indicum essential oils in broad spectrum antibacterial activities.

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The Mission Director (NRHM), National Rural Health Mission Lakshadweep is pleased to invite application from the eligible local candidates who posses the following qualification for filling up 13 post of Ayurvedic Masseur (6 Male & 7 Female ) and One Ayurvedic Pharmacists (Buffer Store / LMS Kochi) under NRHM on contract basis with a monthly remuneration of Rs 10,000/-

About Author:
ATUL KABRA*, NITIN PATEL
Department of Pharmacology
G.H.B Pharmacy college,
Aniyad, Gujarat
* atul.kbr@gmail.com

ABSTRACT:
The antiulcer effect of aqueous fruit extract of Zizizphus jujuba was studied in ethanol induced ulcer model in rats. The extract dose of 50 mg/kg, 100mg/kg, 200 mg/kgproduced significant inhibition of gastric lesion induced by ethanol. The extarct reduced ulcerative lesion, gastric volume, total acidityin ethanol induced ulcer model.The result obtained suggesting that extract possesses significant antiulcer activity. 

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Natural Remedies, a pioneer in phytopharmaceuticals is today credited with integrating scientific approach to search medicines and health supplements ensuring purity, safety and affordability.

The National Brain Research Centre (NBRC) was established by the Department of Biotechnology, Ministry of Science & Technolgy, Government of India, in November 1997 as a fully funded autonomous research institute in the area of neuroscience and brain. The Centre was registered as an Society in June 1999 under the Registration of Societies Act.

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology,

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