PharmaTutor (April- 2014)
ISSN: 2347 - 7881
Received On: 13/02/2014; Accepted On: 21/02/2014; Published On: 01/04/2014
Author: Anjan Khadka
Department of Pharmacology,
AFMC, Pune, India
anjankhadka14@yahoo.com
ABSTRACT:
Interleukins are a subset of a larger group of cellular messenger molecules called cytokines, which are modulators of cellular behaviour. On the basis of their respective cytokine profiles, responses to chemokines, and interactions with other cells, these T-cell subsets can promote different types of inflammatory responses. During the development of allergic disease, effector TH2 cells produce IL-4, IL-5, IL-9, and IL-32. IL-25, IL- 31, and IL-33 contributes to TH2 responses and inflammation. These cytokines have roles in production of allergen-specific IgE, eosinophilia, and mucus. ILs have role in therapeutics as well as diagnosis and prognosis as biomarker in various conditions. Therapeutic targeting of the IL considered to be rational treatment strategy and promising biologic therapy.
How to cite this article: A Khadka, Interleukins in Therapeutics, PharmaTutor, 2014, 2(4), 67-72
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REFERENCES:
1.Vandana T, Bhupinder S K: Cytokines and anti-cytokines as therapeutics — An update.European Journal of Pharmacology 2008, 579, 1–12
2.Toshio T, Masashi N, Tadamitsu K: Therapeutic Targeting of the Interleukin-6 Receptor. Annu Rev Pharmacol Toxicol. 2012. 52:199–219
3.M€ubeccel Akdis, Simone Burgler,Reto Crameri, Thomas Eiwegger,Hiroyuki Fujita, Enrique Gomez et al.:Interleukins, from 1 to 37, and interferon-g: Receptors,functions, and roles in diseases.Allergy Clin Immunol,2011.127,702-721(e1-45)
4.Gabriele G, David B, Joan R: Interleukin 13 and the evolution of asthma therapy. Am J Clin Exp Immunol 2012; 1(1):20-27
5.Aamir Shahzad, Martin Knapp, Irene Lang, Gottfried Köhler: Interleukin 8 (IL-8) - a universal biomarker? International Archives of Medicine 2010, 3:11
6.Jusciele B , AnaMaria CR, Joice MV:Interleukin 10 and Tumour Necrosis Factor-Alpha in Pregnancy:Aspects of Interest in Clinical Obstetrics. ISRN Obstetrics and Gynecology Volume 2012.
7.Lippincott's Illustrated Reviews: Immunology.Paperback.Publisher: Lippincott Williams & Wilkins; (July 1, 2007)
8.Sadaf Ejaz: Role of inflammatory cytokines in inflammation and cancer. Journal of Public Health and Biological Sciences Vol. 2, No. 1 Jan – Mar 2013, p.173-182
9.Brint EK, Xu D, Liu H: ST2 is an inhibitor of interleukin 1 receptor and toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 2004; 5:373–9.
10.Miller AM, Xu D, Asquith DL: IL-33 reduces the development of atherosclerosis. J Exp Med 2008; 205:339–46.
11.P. Kidd: Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Alternative Medicine Review, 2003, 8, 223–46
12.S. Hauguel-de Mouzon, M. Guerre-Millo: The placenta cytokine network and inflammatory signals,Placenta, 2006, 27,794–98.
13.Dmowski WP, Lesniewicz R, Rana N, Pepping P, Noursalehi M: Changing trends in the diagnosis of endometriosis: a comparative study of women with pelvic endometriosis presenting with chronic pelvic pain or infertility. Fertil Steril 1997; 67:238–43.
14.Jamilloux Y, Henry T: The inflammasomes: platforms of innate immunity. Med Sci (Paris). 2013; 29:975-84.
15.Sparmann A, Bar-Sagi D: Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 2004; 6(1): 447–58.
16.Schmitz J, Owyang A, Oldham: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005; 23: 479–90.
17.Wong JY, De Vivo I, Lin X, Fang SC, Christiani DC: The Relationship between Inflammatory Biomarkers and Telomere Length in an Occupational Prospective Cohort Study. PLoS One. 2014 Jan 27; 9(1):e87348.
18.Tang XQ, Sun WP, Xu HB, Liu WB, Wang TS, Liu HJ:The changes in the levels of IL-6, IL-17, and IL-21 in the acute stage of childhood asthma.Clin Lab. 2013; 59(11-12):1381-7.
19.McLean MH, Neurath MF, Durum SK: Targeting Interleukins for the Treatment of Inflammatory Bowel Disease-What Lies Beyond Anti-TNF Therapy? Inflamm Bowel Dis. 2014; 20(2):389-97.
20.Fedorkiv MB, Hudz IM, Shevchuk IM: Prognostication of acute-pancreatitis-associated pulmonary injury based on determination of cytokines levels. Klin Khir. 2013 Jul;(7):28-30
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