PharmaTutor (April- 2014)
ISSN: 2347 - 7881
Received On: 28/02/2014; Accepted On: 08/03/2014; Published On: 01/04/2014
Author: S.O. Pratap1,2, Ruchi Gaur3, R.Stephan4, J.L bhatt3, C.R. Pillai1, Usha Devi1
1Department of Parasitology, Malaria Research Center, New Delhi, India
2Department of Biotechnology, SR Group of Institutions, Jhansi, Uttar Pradesh, India
3School of Life Science, ITM University Gwalior, Madhya Pradesh, India
4Department of Botany, Government P.G. College Ariyalur, Tamilnadu, India
dixitshivom@gmail.com
ABSTRACT:
The natural products are important source of biologically active compounds having potential for developing a novel malaria drug. Malaria is one of the most important infectious vector born parasitic disease caused by Coccidian protozoan parasite of genus Plasmodium carried out by mosquito, invade red blood cells. Malaria is thousand times more complex than any disease. In the current study, a natural ingredient of herb; Dhatura Inoxia is analyzed, for its anti-malarial activity by preparing crude extract of water and ethanol, analyzed on schizont stage of plasmodial life cycle against two Chloroquine strains: sensitive and resistant of Plasmodium falciparum isolates. The results revealed that IC50 values of crude water extract was recorded as; 71± 1.41µg/ml and 105±7.07 while as the ethanol crude extract produced IC50 concentrates: 52±3.53 µg/ml and 59.5± 70 µg/ml against sensitive and resistant P. f. isolates, respectively. The results showed that this herb plant possess significant antiplasmodial activity in terms of IC50 as recorded in this study.
How to cite this article: SO Pratap, R Gaur, R Stephan, JL bhatt, CR Pillai, U Devi, In-vitro screening of Dhatura Inoxia for its anti-Malarial activity against P. falciparum, PharmaTutor, 2014, 2(4), 93-98
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