BITS-RMIT joint Ph.D. program under the supervision of Dr. Gautam Singhvi, Department of Pharmacy, BITS-Pilani, Pilani Campus, India & Dr. Rajesh Ramanathan, and Dr. Vipul Bansal, School of Science, STEM, Royal Melbourne Institute of Technology (RMIT), Melbourne, Australia.
Project Title : Design and evaluation of nanocarriers-mediated topical delivery of combined chemo-photodynamic agents in psoriasis treatment
Project ID : BITSRMIT024B001303
Eligibility : First class in M.PHARM or M.S in Pharmaceutics, drug delivery, Pharmacology, Pharm-Biotechnology, Nanomedicines, or equivalent from a recognized University. As per BITS RMIT PHD program eligibility.
Desirable Criteria : Experience in nanocarriers design, in-vitro characterization, cell line study, and animal study will be preferred.
Highlights
• Acquire an internationally recognized qualification from an Indian Institute of Eminence University and a top Australian university
• Receive a full RMIT tuition fee scholarship for the duration of your enrolment
• Receive a generous scholarship with nominal tuition fees from BITS
• Benefit from the combined expertise of two leading universities and access world-class research facilities in India and in Melbourne
• Travel to Australia for up to one year of candidature and be supported by an Australian stipend for the duration of your time in Melbourne
• Candidates admitted to the program will be jointly supervised by faculty from BITS and RMIT.
Project Description
Psoriasis, a chronic autoimmune condition, affects 2-3% of the global population. In India, prevalence ranged from 0.4% to 0.54% between 2010 and 2020, according to the Global Psoriasis Atlas. Developing targeted medications with the advancements in drug delivery technologies, for localized administration of anti-psoriatic medications, has the potential to enhance treatment outcomes. Incorporating photodynamic therapy as an additional approach in psoriasis treatment can offer promising results by synergistically targeting both the immune response and the proliferation of skin cells. A comprehensive approach with advanced technology using integrated photodynamic therapy and anti-psoriatic agent is essential for improving treatment outcomes. Advanced technologies such as nanocarriers-based drug delivery show promise in improving the efficacy and safety of topical psoriasis treatments by enabling enhanced drug penetration, prolong drug retention at the site of action, and reduce systemic exposure. Therefore the objective of the proposed research work is to explore the combined chemo-photodynamic therapy for psoriasis treatment with nanocarriers for site specific topical delivery. To achieve this, in-vitro investigation of combination index for chemo and photodynamic agent will be performed. The selected combination will be loaded to in-house design nanocarriers system. Further, therapeutic agents loaded nanocarriers will be evaluated for physicochemical characterization, in-vitro cell line study, ex-vivo permeation and in-vivo efficacy in the disease-induced animal model. It is expected that the proposed strategy will provide industrial feasible nanoformulation with improved therapeutic efficacy in the treatment of psoriasis.
Project Deliverable / Outcomes
• Innovative technology enhancing psoriasis treatment efficacy through synergistic approaches. Integration of combination therapy to optimize treatment efficiency and synergistic effects.
• The project will develop efficient nanocarriers based drug delivery system for co-delivery of anti-psoriatic and photodynamic agents.
• Streamlined, cost-effective manufacturing process for scalable product delivery.
• Nanocarrier design prioritizing therapy improvement, patient acceptance, and long-term adherence.
• Emphasis on nanocarrier design simplicity, translational potential, and stability.
• Expected creation of Intellectual Property via patents and publications.
• Opportunity for a research scholar to participate in the project, with the assurance of pursuing a PhD program.
Application Deadline : 06 October 2024
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