Multiple Openings for M.Pharm, MSc at Syngene

Syngene is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit.

Multiple Openings

SPR Scientist
Job Description
Job Purpose
The incumbent will perform SPR/BLI based method development for client projects using Biacore T200/8K and Octet Red96/HTX instruments. He/she has to design experiments, analyze, and compile the data for client sharing.
Key Responsibilities :
• To execute SPR/BLI method development across different functional areas within Syngene discovery biology.
• Able to communicate the findings clearly, document the observations on a day to today basis and report.
• Prepare detailed reports for sharing with clients.
• Improve lab efficiency and streamlines the operational processes to increase productivity.
• Attend training on environment, health, and safety (EHS) measures imparted in the company. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
Candidate Profile
• M.Sc/M.Pharm/M.Tech in Life sciences or related field.
• Prior experience on kinetics estimation with large molecules and therapeutic proteins using Biacore is desirable.
• Theoretical knowledge on protein kinetics estimation and protein-protein interaction.
• Ability to interpret and troubleshoot data generated.
• Knowledge on working with small molecules and membrane proteins in a Biacore instrument will be an added advantage.
• Preferred if having experience in Octet/BLI, ELISA, DSF and other biomolecular interaction/characterization techniques.
• 2-10 years post qualification.
• Take accountability and ownership for respective job function maintain data integrity & exhibit good data management skills.
• Excellent attention to details, diligent documentation, and efficient communication skills
• Good data management by ALCOA+ frame work

MET ID ScientistJob Description
Job Purpose
Bioanalytical scientist with expertise in handling LCMS/MS and support ADME screening assays: InVitro assays, MET ID and large molecule analysis by LCMS and in line with business needs.
Key Responsibilities :
• Optimization of test compounds and to develop high throughput, fit for purpose LC-MS/MS and HPLC-UV methods to support ADME samples analysis : Formulations analysis, solubility studies, stability studies, In vitro assays, MET ID and large molecule analysis etc.
• Perform analysis of samples generated for the screening of compounds for ADME assays and Processing of different matrices/formulation samples of PK studies with no/minimal supervision
• Excellent written and oral communication skills interacting with internal stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, scheduling calibration and maintaining documentation as per regulatory compliance and company policy
• Adhering to safety and quality policies laid by organization
• Delivery of quality data with planning, execution of bioanalytical activities within the team in agreeable timelines
• Development and implementation of high throughput, fit for purpose bioanalytical methods to support invitro ADME samples analysis
• Identification of problem and trouble shooting in quick turn-around time
• Mentoring team members to generate quality data within agreed timelines
• To perform MET ID studies and providing final quality data with interpretation
• Peptide/ large molecule bioanalysis
• Coordination with related invitro verticals to plan the bioanalysis in cassette
• Excellent written and oral communication skills interacting with internal/external stakeholders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsible activities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Adhering to safety and quality policies laid by organization
• Formulation analysis data review and trouble-shooting for quicker resolution
Candidate Profile
• M.Pharm in Pharmaceutical sciences/ Relevant master’s degree in pharmaceutical sciences or instrumentation
• Good communication skills
• Strong problem-solving and handling skills
• Team Player
• Ability to learn/implement new assay in ADME and Analytical
• Quality compliance skills
• Ability to manage a team of professionals to deliver quality work within the time frame, train and coach junior scientists, inculcate good work ethics.
• Ability to work with co‐workers and outside agencies professionally and tactfully.
• Excellent verbal/written communication and ability to communicate effectively with high transparency is essential.
• Interpersonal skills with an emphasis on working in a team environment to accomplish impactful results.

Invitro ADME Scientist
Job Description
Job Purpose
Highly lab-based role, conducting metabolism, Phys-Chem, Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, MDCK-II BCRP transporter assays in 24 well/ 96 well plate trans well assays using different matrices with highest quality
Key Responsibilities :
• Design and execute Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, MDCK-II BCRP transporter assays in 24 well/ 96 well/384 well plate trans well assays
• Able to handle Metabolism and Phys-Chem studies
• Reporting of executed studies without mistakes
• Raw data compilation, Report preparation, eLN updation on time.
• Presenting the study results clearly in the cross functional scientific meetings.
• Follow environment, health, and safety (EHS) requirements at all times in the workplace-ensuring individual and lab/plant safety.
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.
Candidate Profile
• M Pharm. in any pharmaceutical science or M Sc. in biological science.
• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays
• Experience in conducting cell-based assays using wild type and transporter transfected cell lines
• Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism
• Report preparation and review of the reports ready to share with the clients
• Understanding the functionality, operation and maintenance of the instruments (TEER inst, Microscope, biosafety cabinet, LN2, etc.)
• M Pharm. in pharmaceutical sciences or M SC in biological science with 1 to 10 years of Industrial experience in DMPK/ADME research.
• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals

Bioanalytical Scientist
Core Purpose of the Role
• To participate in sample processing for PK, ADME assays and handling of LCMS/MS. Ability to adapt to the dynamic team environment
• Processing of different matrices samples of PK studies
• Optimization of test compounds manually as well as automated on LCMS/MS
• Develop methods with the team lead
• Independently handling of HPLC for UV based samples analysis.
• Documenting the lab note books online and compound management
Candidate Profile
• M.Pharm in Pharmaceutical sciences, Pharmaceutical Analysis who has interest and passion for LC/MS related bioanalysis
• Minimum 2-7 years of experience in handling ADME assays and HPLC and LCMS/MS
• Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory
• Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods
• Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis
• Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required
• Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra
• Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff
• General understanding of Drug metabolism and Pharmacokinetics
• Should be able to deliver scientific presentation in departmental journal club and write official Project reports

Invivo PK Scientist
Core Purpose of the Role
Conduct of in vivo pharmacokinetics study in rodents
Role Accountabilities
• Conduct of pharmacokinetic studies in rodents.
• Documenting the lab notebooks online and compound management.
• Ability to adapt to the dynamic team environment.
• Possess the knowledge and exposure to environment, health, and safety (EHS) practices
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.
Candidate Profile
Experience : 2-8 years post qualification
Education : M. Pharm (Pharmacology & Toxicology)
• Well versed with surgical procedures like cannulation of jugular, femoral, portal vein in rats. Chronic bile duct cannulations in rat and various animal models used for in vivo pharmacokinetics studies.
• Collection of different vital organs during tissue distribution studies in rodents
• Pharmacokinetic data analysis using Phoenix WinNonlin and other data analysis tool.
• Collection of various biological fluids like cerebrospinal fluid, bile, urine, synovial fluid lavage during PK and tissue distribution studies in rodents.
• Should have preliminary understanding about formulations to be used for pharmacokinetics, efficacy and toxicity studies.
• Knowledge about regulatory guidelines followed for drug metabolism and pharmacokinetics is desirable.

Invivo Pharmacology Scientist
Job Description
• Hands-on experience in execution of disease models which includes db/db, ob/ob, ZDF, Zucker, GK rat and STZ models.
• Hands-on experience in handling obesity and dyslipidemia disease models which includes DIO mice, DIO rat, Hyperlipidemic hamster and hyperlipidemic guinea pig models.
• Hands-on experience in mechanistic studies such as OGTT, IVGTT, IPGTT, MMTT, LTT, Euglycemic hyperinsulinemic clamp.
• Will work independently or in association with senior scientists and other associates in the design and execution of in-vivo efficacy experiments in the relevant therapeutic area.
• Experience in animals handling (rodents and non rodents) such as dosing by various routes, bleeding by various routes, injections by various routes and surgical modalities which includes cannulation etc…
• Associate to provide technical, analysis and reporting outcomes of research for projects in relevant therapeutic area.
• Organizational skills and the ability to work in a highly collaborative environment are required.
Candidate Profile
Educational Qualification : M. Pharm degree with 2-8 yrs.
Behavioral Skills : • Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals

Department : Discovery Chemistry, Discovery Biology, E&M, Quality, SARC - CEPA, Computational and Data Sciences, Biopharmaceutical operations
Job Location : Bangalore / Hyderabad
Walk in Interview
Date and Time of registration : 1st Dec 2024, 9:00 am to 12:30 pm
Venue : Syngene International Limited Gate No : 5, Velankani Tech Park, 43, Hosur Rd, Electronics City Phase 1, Electronic City, Bengaluru, Karnataka 560100

SPR Scientist : Click here
MET ID Scientist : Click here
Invitro ADME Scientist : Click here
Bioanalytical Scientist : Click here
Invivo PK Scientist : Click here
Invivo Pharmacology Scientist : Click here