Articles

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Priyanka. Kura, Ashwini. Patlolla, Alluri. Ramesh, Vishwanadham. Y*
Department of Medicinal Chemistry Research Division,
Vishnu Institute of Pharmaceutical Education and Research (VIPER),
Narsapur, Medak, Telangana, India
^*vishwanadham.y@gmail.com

ABSTRACT
The anti-inflammatory drug activity of petroleum ether (Pet.ether) extract of leaves pentas lanceolata was investigated in rats exploitation egg albumen induced paw oedema model. Experimental animals received 20-25 gms (orally) of the extracts five groups divided., control group (saline), test group 50, 100, 200 mg/ kg the standard group received 15 mg/ kg of diclofenac. The results show that the extracts considerably (p <0.05) reduced paw oedema within the albumen induced anti-inflammatory drug activity.

The leaf extract of pentas lanceolata reduced inflamed hind paw diameter of mice by between 0.98%- 3.99% The diclofenac reduced inflamed hind paw diameter by between 1.12%-4.02%. The qualitative phytochemical screening indicated the presence of saponins, flavonoid, alkaloids, terpenoids and cardiac glycosides. The current study establishes potent antiinflammatory activities of pet ether extracts of pentas lanceolata leaves.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Devender Sharma*¹, Kajal V. Kosankar²,
¹Hi – Tech College of Pharmacy, Chandrapur, Maharashtra (India)
²Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra (India).
^*sdevender350@gmail.com

ABSTRACT
“Green tea in green world” it means that healthy green tea in healthy world. As we know when leaves are in green color they are considered as they are fresh and healthy to use. Tea, it is present in two forms that is green or black tea, it is consumed most widely in the world. Extracts of tea leaves it is supplied in the dietary supplements which will maintain the health. However, this review shows an interest in the health care properties of green tea which will help in treatment of cancer which is more dangerous cannot be cure easily. The comparison between black and green tea is given which will help to make a choice. Green tea contains catechins which is an important chemical constituents it shows biological activity like antioxidant, anti-angiogenesis, and anti-proliferative effects and also in treatment of various forms of cancer. This review has much more focus on the biological properties like catechin, epigallocatechingallate (EGCg) show effects on antitumor properties and other health benefits. The antioxidant properties of green are responsible to improvement in cardiac health, atherosclerosis and it has powerful effects on the body. Catechins may reduce cholesterol levels in blood and also improve brain function. The studies show that when caffeine and L-theanine have synergistic effects. Green tea shows fat oxidation about increased by 17%. Green tea contains approximately 20-40% polyphenols and 60-80% catechins such as EGCG by weight. Synergistic properties of polyphenolicconstituents are increasing now a day that are important in medicinal benefits. Tea is now finding its way into topical preparations like patches. The uses of green tea are clinically proved.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Devender Sharma¹*, Ankita A. Bhujbale^2
1Hi – Tech College of pharmacy, 
Chandrapur, Maharashtra, India
²Sinhgad College of Pharmacy, 
Vadgaon, Pune Maharashtra, India
*sdevender350@gmail.com

ABSTRACT
Phytosomes is a novel drug delivery dosage form. Phytosomes is a patented technology. It is used for development of formulation for improved bioavability of medicaments of phytoconstituents present in herbal extract or herbal preparation. Phytosomes is prepared by using the phospholipids and forming the complex between phytoconstituent and phospholipids. Phytosomes now a day’s most valuable space in pharma-industries and good research space for industry scholar, students for future. The main object of this review giving various useful advantages of phytosomes and how it is prepare formulate. Phospholipids are employed as natural digestive aids and carriers for water soluble and lipid soluble nutrients.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Shipra Vermaa, Alok Kumar Srivastava*¹, O.P. Pandeyb
¹Department of Chemistry, Mahatma Gandhi P. G. College, Gorakhpur, U.P., India
²Department of Chemistry, D.D.U. Gorakhpur University, Gorakhpur, U.P., India
^*sdevender350@gmail.com

ABSTRACT
Chalcones are a valuable molecule of medicinal importance due to presence of reactive ketoethylenic group –CO–CH=CH–, belonging to the flavonoid family. These reactive α,β-unsatutated keto function in chalcones are  responsible for their biological activity. Chalcone can be synthesized by several methods using aldehydes and ketones as starting material. This review is focused about different methods of synthesis and versatile biological activity of chalcones including antimicrobial, anticancer, antioxidant, antimalarial, antituberculosis etc.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Devender  Sharma*¹, Aashiya Aara E. Ali ², Leena R. Trivedi^2
1Hi – Tech College of pharmacy, Chandrapur Maharashtra (India)
²Kamla Nehru College of pharmacy, Nagpur, Maharashtra (India)
^*sdevender350@gmail.com
 

ABSTRACT
Liposomes are most placed acquiring in pharma industries and very useful in the various drug delivery system used to target the drug to particular tissue. Because of structural similarity between lipid bilayer (two layer) and cell membrane, liposome can easily penetrate effectively deliver drug to such that a free drug would not easily penetrate. Liposomes can be also encapsulate in both hydrophilic and hydrophobic materials, and are utilized as drug carriers in drug delivery. This technology is very useful for the treatment of certain diseases. Now a day’s most of the researcher attraction and interest will increase for that technology i.e. Liposomes. Main object of this review this technology i.e. Liposomes very useful in certain disease and easily prepare and also give various advantages other than. Liposomes are highly biocompatible, with applications ranging from delivering enzymes, antibacterial, antiviral drugs, antiparasite drugs, transdermal transporters, fungicides, diagnostic tools and adjuvant for vaccines. This paper mainly focus on exclusively scalable techniques and also focus on strength, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.

[adsense:336x280:8701650588]

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
JY Manure, NS Naikwade
Department Of Pharmaceutical Chemistry
Appasaheb Birnale College of Pharmacy,
Sangli, Maharashtra, India
Javeedmanure.98600@yahoo.com

ABSTRACT 
Cancer is a diseases characterized by out-of-control cell growth. There are various types of cancer, and is classified by the type of cell that is affected. Cancer harms the body when altered cells divide uncontrollably to form lumps or masses of tissue called tumors. The recent treatments include chemotherapy, radiotherapy and Surgery. But this treatment accomplished by several side effect like the destruction of bone marrow cell, alopecia etc. So there is a need for the new drug for treatment of cancer. Plant-derived chemical may act as anticancer in many studies. The Plant produces secondary metabolites which are being evaluated for the anticancer activities leading to the development of new drugs. So in this review we have study different plants which act as anticancer. And this will encourage further scientific study of traditionally used plants.

ABOUT AUTHORS
Devender Sharma*¹, Deepika Sarkar^1
1Hi – Tech College of Pharmacy, Chandrapur, Maharashtra (India)
^*sdevender350@gmail.com
{ DOWNLOAD AS PDF }

ABSTRACT
Tuberculosis is a hypersensitive granulomatous infectious disease caused by Mycobacterium Tuberculosis (M.TB).In India 40% people are affected by T.B. So need of knowledge about T.B.  and pathophysiology of T.B. to people or society. Pathophysiology means, when a human being or animal being suffering from a disease this is because deranged or change in function on that organ or human body.  Infection is caused by air- borne droplets of organisms person to person. The main object of this review is how to diagnose and how it is cure or treat. It is diagnosed by PPD, IGRA, Sputum studies, X-rays and Biopsies. Mostly antibiotics are preferred for the first treatment.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
U.Swathi lakshmi¹,  K.Revathi¹ , Dr.P.Shailaja¹, Prof.J.Vijaya Ratna¹, Blessy A. Daniel², Dr.Prashanth.S.^2
1Andhra University College of Pharmaceutical Sciences, Visakhapatnam
²S3V Vascular technologies Pvt.Ltd, Bangalore

ABSTRACT:
The New Medical Device Regulations of European Union replace the E.U’s current Medical Device Directive (93/42/EEC) and the E.U’s Directive on Active Implantable Medical Devices (90/385/EEC) According to the draft document, NB’s would be placed under a strict regimen of super vision, although it remains unclear whether the intended sanctions could be implemented against the will of a Member State, should the need occur. The qualification requirements for auditing and reviewing NB staff are steeply increased. Greater emphasis will be placed on clinical data and the Clinical Evaluation. For implantable medical devices and Class III devices clinical investigations will be expected since equivalence will generally no longer be an acceptable approach, although some exceptions can be made. The proposed MDR attempts to make more transparent the periods for review by various parties for different activities. Implementation of Unique device identification helpful for the unambiguous identification of a specific device on the market.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
SMRUTIPRAGNYA SAMAL, PRATYUSH KUMAR DAS*
Centre for Biotechnology, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India – 751003
*pratyushdas@soauniversity.ac.in

ABSTRACT
Microbial biofilms are complex structures wherein the planktonic cells change their growth mode to the sessile form. This kind of growth is assisted by the formation of a matrix of extracellular polymeric substances (EPS) which encapsulates the bacterial cells within it and thus, provides an additional protection. These biofilms are highly resistant to high concentration of antibiotics and poses a great threat towards public health. These biofilms are even beyond the access of a normal human immune system and are involved in infections of teeth, lungs and many other diseases. There lies an immediate need to replace the extensive use of antibiotics with new emerging strategies. The review intends to provide an insight on the various perspectives of microbial biofilms including their formation, composition, mechanism of communication (Quorum sensing) and pathogenicity. Recent emerging strategies have also been discussed that can be considered for successful eradication or inhibition of biofilms and related infections.