October 2014

Regional Centre for Biotechnology (RCB) is an autonomous academic institution established by the Department of Biotechnology, Govt. of India with regional and global partnerships synergizing with the programmes of UNESCO as a Category II Centre.

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ABOUT AUTHORS:
Lakshmanarao.R*, Pavani Priya.G, Saikishore.V
Department of pharmaceutics,
Bapatla college of pharmacy, Bapatla-522101, India
rapakalakshmanarao@gmail.com

ABSTRACT:
Microspheres are well accepted technique to control the drug release from the dosage form to improve bioavailability, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. The main objective of the present study is to prepare and evaluate ibuprofen  microspheres by solvent evaporation  method, with water insoluble polymers such as Ethyl cellulose and sodium carboxymethyl cellulose as suspending agent, using as carrier for oral administration in view to achieve oral sustained  release of the drug.  Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for relief of signs and symptoms of rheumatoid arthritis, osteoarthritis and is used in chronic and acute conditions of pain and inflammation. Its biological half-life is 2 ±0.5 hrs. Due to its low biological half-life (2 hrs), it requires frequent administration to maintain plasma concentration. This causes inconvenience to the patient and also leads fluctuations in plasma drug concentration that may cause inferior therapeutic effects or toxic effects. There-fore, development of controlled release dosage forms would clearly be beneficial in terms of decreased dosage requirements, thus increase patient compliance. The formulations were evaluated for particle size distribution analysis, flow properties like Angle of repose, bulk density, tapped density, Hausner’s Ratio, Carr’s index, Encapsulation efficiency, Scanning electron microscopy,optical electron microscopy and invitro release studies. The optimized formulation showed good invitro sustained  release activity of the drug ibuprofen.

The Indian Pharmacopoeia Commission (IPC) is an Autonomous Body, set up under the Ministry of Health & Family Welfare primarily with the objective of periodically updating of the Indian Pharmacopoeia, the book of standards for the drugs; the National Formulary of India, the book of reference on the drugs; and other related tasks such as preparing, certification and distribution of Reference Substances; assist the National Pharmacovigilance Programme; testing of the new drugs and review of Technical dossier of Drugs for purpose of monograph development for the Indian Pharmacopoeia. It promotes rational use of medicines through generic prescriptions. The IPC is on path of evolving as a modern scientific institution.

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Walk-in Interview has been scheduled for the following vacant positions in the SERB, DST-funded research project (DST Ref. No. IR/ SO/ LU/ 0008/ 2011; Dated, 3.7.2012) entitled, “National Center for Natural Resources.”

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