September 2013

ABOUT AUTHORS:
Shankar Soni¹*, Dr. Puspendra singh Naruka¹, Sunil kumar ola^2
1B N College Of Pharmacy, Udaipur
²Goenka College Of Pharmacy, Laxmangarh
*slsoni85@gmail.com

ABSTRACT
The present work was aimed at formulation development, evaluation and comparative study of the effects of ethyl cellulose in Itopride HCL CR pellets. The controlled release polymers used for the present study were Ethylcellulose N-14 and Ethylcellulose N-20. The formulated pellets were evaluated for various pellet properties, like hardness, bulk density, tapped density, cars index and dissolution rate. Comparative evaluation of the above-mentioned parameters established the superiority of the pellets formulated with Ethylcellulose those formulated with different grades.
The main objective of this work is to develop and explore formulation as sustained release pellets of Itopride hydrochloride.From the literature it was found that different carriers like ethyl cellulose N-20, Ethyl cellulose N-50 were used to prepare controlled release pellets of water soluble drugs. Hence, in the present investigation it is aimed to test the suitability of using ethyl cellulose in the development of gastric retentive systems and for controlling the drug release from the pellets.

About Authors:
Sarepaka a.^*1, Dhamodaran p.¹, Singh a.², Nilani P.¹, Duraiswamy B^1
1Department of Pharmacognosy, JSS College of Pharmacy, Ootacamund, Tamilnadu, India 643001
²Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, Tamilnadu, India 643001

The Indian Pharmacopoeia Commission (IPC) is an Autonomous Body, set up under the Societies Registration Act, 1860 by the Ministry of Health & Family Welfare primarily with the objective of periodically bringing out new edition of the Indian Pharmacopoeia, National Formulary of India and other related tasks such as preparing, certification and distribution of Reference Substances.

Pharmaceutical Analysis

INTRODUCTION
Pharmaceutical analysis is a branch of practical chemistry that involves a series of process for identification, determination, quantification and purification of a substance, separation of the components of a solution or mixture, or determination of structure of chemical compounds.