January 2013

About Authors:
Dharmendra Kumar^*1, Sumedha Bansal^1
1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
Meerut, Uttar Pardesh, India, 250005
*rvnimiet@gmail.com

Abstract:
In present era, nasal drug delivery system has been considered as potential and favourable route of drug delivery because it provides patient compliance, easy to administration, bypass first pass metabolism, excellent penetration, low dose required, rapid absorption and gives desirable effects. So many times nasal drug delivery has been considered as alternative of parenteral route. The purpose of this review, to provide a complete information about nasal drug delivery system such as advantage, limitations, anatomy of nose, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, novel drug formulations, types of nasal drug delivery system with uses of nasal drug delivery in various disease. So we have expectation, that researches and others cited person get benefitted from this review.

About Author:
Bandana patel
Shri Ram Institute Of Technology
Jabalpur(M.P.) 482002
Vandanapatel.mbbs@gmail.com

Abstract:
Tagetes erectus leaf  were evaluated against various gram +ve and gram–ve bacteria and fungi, ethanol extracts exhibited very satisfactory inhibitory activity. Further studies involving the isolation, characterization and purification of the chemical compounds of the plant and screening for antibacterial and antifungal may result in the development of a potent entity which will be of lower toxicity and a high therapeutic value to the mankind.

A walk in interview has been kept on 12/1/2013 at 10.00 am at Collectorate, Dadra & Nagar Haveli, Silvassa to fill up the below mentioned post under Rogi Kalyan Samiti, Shri Vinoba Bhave Civil Hospital, Silvassa on short term contract basis.

Post: Pharmacist, Group C

Regional Plant Resource Centre was established in 1985 as a recreational garden and with an aim to provide a green lung for the inhabitants of Bhubaneswar – the capital city of Orissa. Gradually it became a dynamic and vibrant research organization of the State Government with a focus on the conservation of plant biodiversity.

About Authors:
Aditya Dixit¹, Gyanendra Kumar Sharma², Devender Pathak^*3
1M. Pharmacy (Pharmaceutical Chemistry)
²Associate Professor (Pharmaceutical chemistry)
³Director, Professor and Head of the Dept. (Pharmaceutical Chemistry)
Rajiv Academy for Pharmacy, Mathura,
Delhi-Mathura Highway, Chhattikara, 281006, India
dev_15@rediffmail.com*, adixit70@gmail.com

ABSTRACT
A traditional but effective method of developing new targets is lead molecule modification, where an existing popular drug from the market is taken as a lead and similar derivatives are synthesized. With the advent of modern techniques conventional methods have lost their gleam but, reactions are still best understood when performed by the conventional techniques. One such endeavor has been made here where indole has been used as a parent moiety and by adding some functional groups some novel indole derivatives were synthesized and screened for their in vitro antitubercular, and anticancer activity. This synthesis of some fresh indole derivatives was done by using various benzaldehyde derivatives and 2-(o-Aminophenyl)indole in acidic condition then with ammonium acetate and isatin in presence of glacial acetic acid.. The structures of newly synthesized compounds were characterized by IR, ¹H NMR, MASS and elemental analysis.Compounds 3h & 3i showed good antitubercular activity and 3d, 3e & 3g showed good anticancer compared to the standard drug.

The Maharaja Sayajirao's grandson Sir Pratapsinghrao Gaekwad who founded the Maharaja Sayajirao University and settled the trust as desired by his grandfather. This Trust known as Sir Sayajirao Diamond Jubilee and Memorial Trust exists today also and caters to the educational and other needs of the people of the former state of Baroda.