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January 2013

 

 

academics

 

Clinical research courses

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 3-(2-(1H-INDOL-2-YL) PHENYL)-2-ARYLIMIDAZO[4,5-b]INDOLES

About Authors:
Aditya Dixit1, Gyanendra Kumar Sharma2, Devender Pathak*3
1M. Pharmacy (Pharmaceutical Chemistry)
2Associate Professor (Pharmaceutical chemistry)
3Director, Professor and Head of the Dept. (Pharmaceutical Chemistry)
Rajiv Academy for Pharmacy, Mathura,
Delhi-Mathura Highway, Chhattikara, 281006, India
dev_15@rediffmail.com*, adixit70@gmail.com

ABSTRACT
A traditional but effective method of developing new targets is lead molecule modification, where an existing popular drug from the market is taken as a lead and similar derivatives are synthesized. With the advent of modern techniques conventional methods have lost their gleam but, reactions are still best understood when performed by the conventional techniques. One such endeavor has been made here where indole has been used as a parent moiety and by adding some functional groups some novel indole derivatives were synthesized and screened for their in vitro antitubercular, and anticancer activity. This synthesis of some fresh indole derivatives was done by using various benzaldehyde derivatives and 2-(o-Aminophenyl)indole in acidic condition then with ammonium acetate and isatin in presence of glacial acetic acid.. The structures of newly synthesized compounds were characterized by IR, 1H NMR, MASS and elemental analysis.Compounds 3h & 3i showed good antitubercular activity and 3d, 3e & 3g showed good anticancer compared to the standard drug.

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Maharaja Sayajirao University of Baroda invites invites Technical Assistant, Laboratory Assistant | 4 Posts

The Maharaja Sayajirao's grandson Sir Pratapsinghrao Gaekwad who founded the Maharaja Sayajirao University and settled the trust as desired by his grandfather. This Trust known as Sir Sayajirao Diamond Jubilee and Memorial Trust exists today also and caters to the educational and other needs of the people of the former state of Baroda.

Application are invited for Junior Research Fellow in Indian Institute of Science Education and Research

Indian Institute of Science Education and Research (IISER) Pune is a premier autonomous Institution established by the Ministry of Human Resource Development, Government of India, for promotion of high quality science education and research in the country.

Post: Junior Research Fellow- 1

MODIFIED LIPID VESICLES, ETHOSOMES AND INVASOMES: POTENTIAL CARRIERS FOR TRANSDERMAL DRUG DELIVERY

About Authors:
Ravindra K. Kamble, Priyadarshani R. Kamble*
Department of Pharmaceutics and Quality Assurance,
Bhupal Nobles’ College of Pharmacy, Udaipur, Rajasthan, INDIA.
*priya.s.bansode@gmail.com

ABSTRACT
Recent studies reported approval of lipid vesicles as drug carriers for chemotherapeutic agents and bio-actives which have been revealed in a number of lipid vesicles based formulations, which are commercially available or are currently undergoing clinical trials. This review is mainly focused on effectiveness and permeation enhancing controversy of lipid vesicles as dermal and transdermal drug delivery with special emphasis on recent advances in this field, including the development of deformable vesicles, ethosomes and invasomes. Only specially designed lipid vesicles have been shown to be capable of achieving enhanced delivery. The incorporation of additives, such as anionic surfactants and ethanol, fluidize the phospholipid bilayers, thus can penetrate the intercellular pathways of the skin.

DISCUSSION ON RADIOISOTOPE & RADIOPHARMACEUTICAL: IT’S USES

About Authors:
C.P.Meher*, S.P.Sethy, B.Pochaiah
Asst. Professor
Maheshwara Institute of  Pharmacy,
Department Of Pharmaceutical Chemistry
Chitkul, Patancheru, Medak, A.P
*chaitanyameher84@gmail.com

ABSTRACT
Radioactive isotope, also called radioisotope,  any of several species of the same chemical element with different masses whose nuclei are unstable and dissipate excess energy by spontaneously emitting radiation in the form of alpha, beta, and gamma rays. Radioisotopes are elements that are atomically unstable and radioactive. Radioisotopes stabilize by releasing energy and matter. Natural radioisotopes, which have relatively low radioactive energy, have been largely replaced by artificially produced radioisotopes. Artificially produced radioisotopes are widely utilized as sources of radiation for radiography, gauging, and as tracers for a multitude of measurements that are not easily made by other methods. Radiopharmaceuticals are drugs containing a radionuclide and are used routinely in nuclear medicine for the diagnosis and therapy of various diseases. Presented article is concerned with brief discussion about the radioisotope & Radiopharmaceuticals.

Submitted by admin on 4 January 2013

Urgently Required Faculty For Pharmacovigilance (Oracle Argus Safety 6.0) at Hyd.

Hi,
  we are an end-to-end clinical research Consulting firm in Hyderabad. We are looking for the part time faculty (part time) for Pharmacovigilance (Oracle Argus Safety 6.0) at Hyderabadlocation

Exp: 0-1 years
should have Good Communication skills.

Candidate must be having knowledge on Oracle Argus safety software.

Local candidates (Hyderabad) only.

Opening for M.Pharm as Project Associate in Indian Institute of Technology Kanpur

Job as Senior Executive / Assistant Manager in Biocon

Biocon is a research-driven, global healthcare company with a strong matrix of capabilities along the biopharmaceutical value chain. Focusing on unmet medical needs in cancer, diabetes and inflammatory diseases, it offers novel therapies on a platform of affordable innovation.
Biocon together with group companies employs more than 2500 employees with approxmimately Rs 1,000 crore turnover and is expected to grow further during the current financial year.

Application for Ayurvedic Compounder in Municipal Corporation of Delhi

Municipal Corporation of Delhi is among the largest municipal bodies in the world, providing civic services to more  11 million citizens in the capital city of India, covering an an area of 1,397.3 sq. km. Within its jurisdiction are some of the most densely populated areas in the world. It has also the unique distinction of providing civic services to rural and urban villages, resettlement colonies, regularised unauthorised colonies, Slum/Squatter Settlements etc.

Vacancy for Quality Specialist, Process QM in PAREXEL

PAREXEL has developed significant expertise to assist clients in the worldwide pharmaceutical, biotechnology and medical device industries with the development and launch of their products in order to bring safe and effective treatments to the global marketplace for the patients who need them. Headquartered near Boston, Massachusetts, PAREXEL operates in 71 locations throughout 54 countries around the world, and has over 9,500 employees.