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September 2012

RECENT ADVANCES OF LACCASE ENZYME IN INDUSTRIAL BIOTECHNOLOGY : A REVIEW

About Authors:
Alpeshkumar J.Shiroya*
Bhagwan Mahavir College Of  Biotechnology,
Surat
alpeshshiroya45@yahoo.in

ABSTRACT
Laccases are an interesting group of multi-nuclear copper-containing oxidoreductases, which have been subject of intensive research in last decades due to their ability to oxidize both phenolic and nonphenolic lignin related compounds as well as highly recalcitrant environmental pollutants, which makes them very useful for their application to several biotechnological processes. These oxidase enzymes catalyze oxidation of substrates at the expense of molecular oxygen and produce water as the only by-product. Lacasses are present in higher plants, bacteria, fungi, insects and lichens. The oxidative ability of laccases is employed in a number of industrial and environmental applications including bioremediation, food technology, nanobiotechnology, medicine, pulp and paper industry, textile industry, and cosmetology. Owing to its versatility, laccase is continuously under investigation for new applications. In the recent years, laccases are also used as cleaning agents for certain water purification systems, as catalysts for the manufacture of anti-cancer drugs and even as ingredients in cosmetics. More recently, it is also used in the design of biosensors, biofuel cells, as a medical diagnostics tool and bioremediation agent to clean up herbicides, pesticides and certain explosives in soil. This paper reviews the occurrence, mode of action, general properties, production, immobilization, molecular cloning, and important  application  of laccases  within different industrial and biotechnological area.

Multiple vacancies in Multani Research Foundation | Require QA Officers, QA Manager, Microbiologists, F&D Scientists, Analytical Scientists - Fresher may also apply

Multani Research Foundation was established with an objective to develop & deliver best Quality Drugs affordable by needed ones based on scientific rationale and knowledge of Ayurveda. To meet its expansion plan in the area of new range of FMCG and Herbal Drugs development required following personnel.

Guru Nanak Hospital & Research Centre looking for Pharmacist

To the great Guru Nanak who was an apostle of peace, truth and universal brotherhood, there could not be a better tribute on his 500 birth-day than the decision to build a "State of the Art" Hospital & Research Centre in the Metropolis of Bombay. The ailing society and suffering mankind, which Guru Nanak loved the most, sorely need such facilities.
The driving force behind this noble venture are the disciples of the great Guru spearheaded by the Shree Singh Sabha, Bombay.

Application from local candidates are invited to fill up the post of Pharmacist by Sikkim Public Service Commission- 2 posts

The Sikkim Public Service Commission started functioning from 1982 with the appointment of the Chairman and deputation of the staff from the State Government. Since then, the Sikkim Public Service Commission has been entrusted with the work of conducting Union Public Service Commission examinations.

MARSAP invites for Sales positions, Application Specialist | graduate/post-graduate in Pharmacy

They are a group of companies in the business of analytical instruments for the last 25 + years. Under Marsap Services Pvt. Ltd., they represent world-class manufacturers of instruments for use in Petrochemical, Pharmaceutical, Life Sciences and Biotechnology application. Their sister concern, Anamed Instruments Pvt.

Job as Junior Research Fellow in Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST)

Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Thiruvananthapuram is an Institute of National Importance  established by an Act  of the Indian Parliament  and  under the 2 administrative control of the Department of Science and Technology, Government of India.

National Institute for Research in Reproductive Health (NIRRH) invites Junior Research Fellow (JRF), Project Assistant- 6 Posts

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai.

SURVEY ON DIABETES AND STANDARDIZATION OF POLYHERBAL FORMULATION

About Authors:
1Shambhawi, *Sai Saraswathi V
1*Pharmaceutical Chemistry Division,
School of Advanced Sciences,
VIT-University, Vellore-632014,
Tamilnadu, India.
1shambhawi06@yahoo.co.in, * v.saisaraswathi@vit.ac.in

ABSTRACT :
Standardization of polyherbal formulation is important to validate the quality of drugs and to ensure that the consumers are getting medication which guarantees purity, safety, potency and efficacy. The present paper reports standardization of traditional ayurvedic liquid polyherbal antidiabetic formulation (Sucrogen) and diabetes survey for retrieving the information on medication along with the lifestyle of diabetic population. Sucrogen was standardized based on ayurvedic pharmacopeia physico-chemical properties, preliminary phytochemical tests, organoleptic characters, stability studies, microbial studies, TLC, HPLC, heavy metal estimation by AAS and flame photometry to fix the quality standard of this drug. Invitro anti-diabetics activity of the drug was determined using alpha amylase Inhibitory method.These studies resulted in a set of diagnostic characters essential for its standardization. The phytochemical constituents found to be present in raw materials used for the preparation of Sucrogen possibly helps in achieving the desirable therapeutic efficacy of the ayurvedic formulation.
OBJECTIVE
To do a general survey on diabetes and to standardize the polyherbal formulation consumed by the population of Jharkhand for the determination of purity and quality of drug

A REVIEW ON CONTROLLED DRUG DELIVERY SYSTEM BY CHITOSAN HYDROGEL

About Authors:
SHAMBHAWI*, M SHIVASHANKAR
School of Advanced Sciences, Pharmaceutical chemistry division,
VIT University, VELLORE

India

ABSTRACT:
Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. Hydrogels are a unique class of macromolecular networks that can hold a large fraction of an aqueous solvent within their structure. The objective of this paper is to give a brief review on the fundamentals and recent advances in chitosan based hydrogel for e.g., thermosensitive hydrogel variants which precludes the need of surgical implantation as well as the description of the release mechanism of bioactive molecules from these hydrogels which traps a drug and then releases the active compound by "Swelling" or expanding inside of specific tissues, thus allowing a higher concentration of the drug in a biodegradable format. This article presents an overview of the newest developments and applications of Chitosan based hydrogel for controlled drug delivery system.