September 2012

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About Author:
Ashutosh Gupta
B.Pharm, kanpur university
22ashutoshgupta22@gmail.com

Abstract
This summary represents the Food and Drug Administration’s (FDA’s) current thinking on this topic. It does not create or confer any rights for or on any person and does not operate to bind FDA or the public. You can use an alternative approach if the approach satisfies the requirements of the applicable statutes and regulations. If you want to discuss an alternative approach, contact the FDA staff responsible for implementing this guidance.

About Authors:
*Virendra Sharma, Pooja Sinoriya, Sunil Sharma
Lakshmi Narain Academy of Pharmacy, Gwalior
Kumud23@indiatimes.com

Abstract
To evaluate the anti-inflammatory and analgesic activity of methanolic extract of whole plant of Sida acuta in experimental animal models. Methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.) was studied for its anti-inflammatory activity using Carrageenan induced rat paw edema animal model and analgesic activity at the same dose level using acetic acid induced writhing test and Hot plate analgesia in mice. The methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.). The PI with indomethacin and Sida acuta in carrageenan induced paw edema  at the dose level 400 mg/kg were 60% and 52.5% at the end of 5 hr. In the acetic acid induced writhing test, the extract at the dose level 400 mg/kg showed 83.78% inhibition of writhing. In radiant heat tail- flick method the extract  at the dose 400 mg/kg showed reaction time 4.902 ± 0.545 (p<0.001). The methanolic extract possesses anti-inflammatory and analgesic activity.

About Authors:
S. H. Seyed Mohamed Buhary*, Kamarapu Nagaraju, A. Thanga Thirupathi.
Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy,
Sivakasi, Tamil Nadu, India.
* nagarajukamarapu8@gmail.com

ABSTRACT:
The main goal of this study was to develop a stable formulation of antibiotic drug clarithromycin as an immediate-release tablet. The task of developing immediate release tablet is accomplished by using a suitable diluents and super-disintegrants. Faster disintegration of the tablet administrated orally minimizes absorption time and improves its bioavailability in less time.   The formulation development work was initiated with wet granulation. Microcrystalline cellulose PH 102 were used as diluent. Povidone was used as the binder. Croscarmellose sodium and pre gelatinized starchwas added as a disintegrating agent. Talc and magnesium stearate was used as the lubricant. The prepared granules were compressed into a compression machine.  To evaluate the formulated tablets as per requirements of standards. The tablets thus formulated showed  a satisfactory physical parameters, and it was found to be stable.Evalution Parameters Like weight variation, hardness of the tablet, friability, thickness, disintegration test, drug content uniformity and in vitro release studies were performed.To optimize the trial batch by    3² full factorial design study and determined  the best batch by in vitro release studies are showed that  optimization formulation (OF7) was 101.62% respectively. The  optimized formulation is further selected and compared with the release profile of the innovator product. The results suggest the feasibility of developing immediate  tablets consisting of clarithromycin for the convenience of patients with respiratory infections, gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis and Mycobacterium avium complex (MAC) in patients with advanced HIV disease.

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