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April 2012

 

 

academics

 

Clinical research courses

DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF GLIBENCLAMIDE

About Authors:
SINGH GAURAV*, GOKULAN DR P.D., KINIKAR DHANANJAY, KUSHWAH MANOJ
Shri Ramnath Singh Institute Of Pharmaceutical Science and Technology,
Sitholi, Gwalior, M.P

*gaurav.robby@gmail.com

ABSTRACT
Glibenclamide is an oral hypoglycemic drug with very low aqueous solubility. The drug is completely metabolized in liver, its principle metabolite being very weakly active, buccal film may be more efficacious for the treatment of diabetes. The objective of this work is to investigate the feasibility of obtaining the slow release, obtaining relatively constant levels of Glibenclamide from buccal films. The films were fabricated by solvent casting technique with different polymers HPMC, Sodium CMC and PVP and systematically evaluated for in vitro and ex vivo performance. Propylene Glycol is employed as plasticizer and penetration enhancer. Hydroxypropyl methyl cellulose is acting as film forming polymer, Sodium CMC and PVP are employed as mucoadhesive polymer.  The formulation containing HPMC and Sodium CMC (F2) showed better controlled results correlated with ex vivo permeation studies.

Opportunity for M.Pharm & M.Sc to join in National Institute of Nutrition as SRF through Walk in Interview

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr.

Work as Executive – Stores with Himalaya Healthcare

The Himalaya Drug Company was founded in 1930 by Mr. M. Manal with a clear vision to bring Ayurveda to society in a contemporary form and to unravel the mystery behind the 5,000 year old system of medicine. This included referring to ancient ayurvedic texts, selecting indigenous herbs and subjecting the formulations to modern pharmacological, toxicological and safety tests to create new drugs and therapies.

BHU invites JRF for projects on Functional Genomics and Proteomics - 2 posts

Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

PMT jobs : Require Product Executive/ Manager in Apex Laboratories - 3 posts

Apex is a people based organization and its strengths flow from its people. Apex is among the ‘top 50 fastest growing Indian pharma companies’, with most of its products enjoying leadership position in their segments. The company has ambitious plans to expand its product portfolio and expand its reach in the international market.

MICROSPHERES: FORMULATION & EVALUATION

About Authors:
Piyush Gupta*
Department of Pharmaceutics,
Regional College of Pharmacy,
Jaipur, Rajasthan

ABSTRACT:-
The term MICROSPHERE is defined as a spherical particle with size varying from 50nm to 2µm, containing a core substance. Microspheres are, in strict sense, spherical empty particles.However, the terms microspheres and microencapsulationare used synonymously. In addition, some related terms are “beads” are used alternatively. Spheres and spherical particles are also usedfor a large size and rigid morphology. The microspheres are characteristically free flowing powders consisting of proteins orsynthetic polymers, which are biodegradable in nature, andideally having a particle size less than 200 micrometer. Novel Drug Delivery Systems are developed to address the challengesof drug development such as Bioavailability, Permeability & Poor solubility. These demand changes in the conventional use of Excipients, the growth of the Biotechnology industry,including Stem cell therapy,Vaccines & Genetic products, also necessitates different drug delivery requirements, there by demonstrating the acceptance of these excipients by the US food & drug administration or other agencies in the major markets.For materials in which Toxicity is a possible concern, formulators can give information about the excipients regulatory acceptance& allowable amount by consulting with excipients manufactures& toxicology experts.

Walk in for Executive- API Production in CIPLA - 9 posts

Cipla known for its innovative pharmaceutical products backed by latest in technology and creative marketing practices, is enjoying a commanding position among the top pharma companies in the country.
Several specialised therapeutic divisions and promising new products have been launched and many more are in the pipeline.

Opportunities in Pharma and Lifescience institutes and companies in the month of February 2012

February 2012

Multiple vacancies for Scientist - B in KFRI - 17 posts

Kerala Forest Research Institute (KFRI) is a leading organization in the field of research in tropical forestry, biodiversity and sustainable bioresource utilization. To consolidate our position and to prepare for the emerging challenges in these areas, we invite dynamic and talented Scientists who are actively pursuing research in selected disciplines, to join our team. KFRI offers the CSIR scales of pay (Scientist B: Rs. 15600-39100 + grade pay Rs. 5,400/- and Scientist-E1 Rs. 15600-39100 + grade pay Rs.

Career in BHAILAL AMIN GENERAL HOSPITAL as Pharmacists - 3 posts

BHAILAL AMIN GENERAL HOSPITAL, VADODARA, GUJARAT is an 'ISO 9001:2000' certified hospital and has turned more special with all the health-care amenities 'under one roof'.