March 2012

THIS JOB IS EXPIRED !

With a pedigree from the Personal Care and Pharma industries, VSCL's management brings with it vast product and customer experience. Beyond the leaders, each of our employees have been culturally sensitized to the special quality needs required by our industry, and fully support all our quality initiatives.

Elder Pharmaceuticals is a Mumbai based pharmaceutical manufacturing & marketing organisation. By virtue of its strategic alliances, synergetic acquisitions globally accredited manufacturing facilities & above all an extensive marketing & distribution network, Elder Pharma is one of the fastest growing pharma companies in India.

SIRO Clinpharm is one of the leading Global Clinical Research Organizations (CROs), offering full scope services conducting clinical trials in the Pharmaceutical, Biotechnology and Medical Devices sectors in compliance with International Standards. We are headquartered in India having global presence in USA, Israel and in Europe at Germany, Czech Republic, Greece, Estonia, Romania, Spain and France.

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr.

Canbari Healthcare is delhi based company.

Post: Medical Representative

About Authors:
Manoj Kumar Jadia^1*, U.L.Narayan^2
1 Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceautical Sciences, I.R.C. Village, Bhubaneswar, Dist:Khurda, Odhisa -751015
² Principal, Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceautical Sciences, I.R.C. Village,
Bhubaneswar,
Dist:Khurda, Odhisa -751015

Abstract:
Two methods are described for the simultaneous determination of Paracetamol and Chlorzoxazone in binary mixture. The first method was based on UV-spectrophotometric determination of two drugs, using simultaneous equation method. It involves absorbance measurement at 282.5 nm (λmax of Chlorzoxazone) and 248.0 nm (λmax of Paracetamol) in methanol; linearity was obtained in the range of 5 – 25 μg.mL-1 for both the drugs. The second method was based on HPLC separation of the two drugs in reverse phase mode using Promosil C18 column. Linearity was obtained in the concentration range of 100-500 μg.mL-1 for Paracetamol and 50-250 for  the Chlorzoxazone. Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.