February 2012

ABOUT AUTHORS:
G. JYOTHI REDDY*¹, A. SRILAKSHMI¹, S.SINDHUJA², N.K. SREE¹, SK.AFSAR¹, B.PRIYANKA¹, R.E.AMRUTHA^1
1 Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
² Sri Padmavathi School Of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India

ABSTRACT
The ethanolic leaf extract of Allophylus serratus shown significant (p<0.05) antidiarrheal activity on gastrointestinal motility with  castor oil- induced diarrheal model in rats. The results obtained revealed that the leaf extract possess pharmacological activity against diarrhoea and may possibly explain the use of the plant in traditional medicine. The extract tested at 200 and 400 mg/kg like the standard drug, loperamide significantly inhibited the frequency of defecation droppings compared to untreated control rats. This result is in support of previous claims in respect of antidiarrhoeal herbs.

About Authors:
Dr. BJ Mahendra kumar^*1, Jagadish babu D², Jyothi K²,
^*1Professor, Department of Clinical pharmacy,
Sri Adichunchanagiri College of pharmacy, Mandya, Karnataka, India.
²Scholars, Department of Clinical pharmacy,
Sri Adichunchanagiri College of pharmacy, Karnataka,
Mandya, India.

Introduction:
Antibiotics are among the most widely prescribed therapeutic agents among paediatrics patients.¹ As we all know, the advantage of therapy with a cephalosporin not only lies in its rather broad spectrum but also in its low toxicity and the drug can be used safely in pregnant women and children. Such therapy can reduce the duration of hospitalization if the susceptible bacterial pathogens have been almost eradicated by a parental cephalosporin and patient’s condition has been brought under control.² Despite their widespread use in paediatrics, few antibiotics have been studied adequately to be considered safe and effective for use in children. Oral third-generation cephalosporins used commonly in paediatrics include cefixime, cefpodoxime, ceftibuten, and cefdinir.³

Parenteral Drugs (India) Limited is one of the leading and fastest growing healthcare company, that has constantly followed a path created by its own will, hard work and determination. PDPL is involved in research, production and manufacturing of pharmaceutical products viz. intravenous infusion, tablets, capsules, liquids syrups, injections etc.